ENSG00000103496

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313843 ENSG00000103496 HEK293_OSMI2_2hA HEK293_TMG_2hB STX4 protein_coding protein_coding 50.86873 72.69517 36.68098 2.854433 0.08821843 -0.9866326 29.056782 45.951843 20.938138 1.5751017 0.88589599 -1.1336146 0.56527500 0.63236667 0.57080000 -0.06156667 2.361737e-01 5.486893e-10 FALSE  
ENST00000487411 ENSG00000103496 HEK293_OSMI2_2hA HEK293_TMG_2hB STX4 protein_coding retained_intron 50.86873 72.69517 36.68098 2.854433 0.08821843 -0.9866326 3.722590 1.998581 3.546511 0.3602964 0.56851597 0.8242861 0.08188333 0.02716667 0.09670000 0.06953333 6.869601e-05 5.486893e-10 FALSE  
ENST00000496977 ENSG00000103496 HEK293_OSMI2_2hA HEK293_TMG_2hB STX4 protein_coding nonsense_mediated_decay 50.86873 72.69517 36.68098 2.854433 0.08821843 -0.9866326 2.711654 1.532716 3.165903 1.5327162 0.37426804 1.0416944 0.05778750 0.02063333 0.08633333 0.06570000 1.037683e-01 5.486893e-10 FALSE  
ENST00000613541 ENSG00000103496 HEK293_OSMI2_2hA HEK293_TMG_2hB STX4 protein_coding protein_coding 50.86873 72.69517 36.68098 2.854433 0.08821843 -0.9866326 6.330686 10.936681 3.242030 0.6542647 0.03939511 -1.7510809 0.11725833 0.15040000 0.08840000 -0.06200000 7.430004e-06 5.486893e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103496 E001 0.0000000       16 31032889 31032909 21 +      
ENSG00000103496 E002 0.0000000       16 31032935 31032999 65 +      
ENSG00000103496 E003 0.8814403 0.0141026320 1.183882e-01 2.176215e-01 16 31033000 31033076 77 + 0.001 0.318 9.459
ENSG00000103496 E004 0.7321030 0.0563077465 8.242319e-01 8.892794e-01 16 31033095 31033306 212 + 0.173 0.218 0.406
ENSG00000103496 E005 0.9535482 0.1026515459 6.143263e-01 7.328305e-01 16 31033307 31033389 83 + 0.173 0.273 0.836
ENSG00000103496 E006 5.9080331 0.0582553645 8.919585e-01 9.350055e-01 16 31033390 31033522 133 + 0.806 0.791 -0.059
ENSG00000103496 E007 6.8511529 0.0657868199 4.103570e-01 5.539587e-01 16 31033523 31033545 23 + 0.947 0.824 -0.469
ENSG00000103496 E008 6.8919510 0.0764692813 5.623482e-01 6.899813e-01 16 31033546 31033546 1 + 0.923 0.837 -0.327
ENSG00000103496 E009 9.8245567 0.0970170376 5.054615e-01 6.412300e-01 16 31033547 31033556 10 + 1.054 0.971 -0.306
ENSG00000103496 E010 11.3066359 0.1126330746 2.572304e-01 3.942968e-01 16 31033557 31033557 1 + 1.169 0.995 -0.629
ENSG00000103496 E011 27.9074713 0.0063179999 5.996508e-04 2.531804e-03 16 31033558 31033587 30 + 1.584 1.331 -0.870
ENSG00000103496 E012 27.0259292 0.0067157940 6.633488e-04 2.764518e-03 16 31033588 31033591 4 + 1.572 1.317 -0.879
ENSG00000103496 E013 34.1668063 0.0104541432 9.608199e-03 2.779891e-02 16 31033592 31033605 14 + 1.631 1.435 -0.671
ENSG00000103496 E014 246.1913403 0.0033757802 9.268467e-01 9.579548e-01 16 31033606 31033785 180 + 2.340 2.340 0.002
ENSG00000103496 E015 227.9760135 0.0017824270 1.458288e-01 2.559936e-01 16 31033786 31033804 19 + 2.268 2.320 0.175
ENSG00000103496 E016 253.3323498 0.0021400324 5.084294e-01 6.438359e-01 16 31033805 31033835 31 + 2.333 2.358 0.086
ENSG00000103496 E017 384.0730337 0.0008538273 2.817548e-01 4.216740e-01 16 31034013 31034114 102 + 2.510 2.541 0.104
ENSG00000103496 E018 1.0975895 0.0136228400 4.811046e-01 6.193477e-01 16 31034115 31034203 89 + 0.393 0.270 -0.773
ENSG00000103496 E019 24.3221144 0.0177480046 9.956498e-01 1.000000e+00 16 31034204 31034225 22 + 1.345 1.356 0.039
ENSG00000103496 E020 409.6164722 0.0019537579 3.170213e-01 4.598537e-01 16 31034226 31034325 100 + 2.537 2.570 0.108
ENSG00000103496 E021 21.1379988 0.0172304173 1.994061e-03 7.208091e-03 16 31034326 31034461 136 + 1.484 1.191 -1.020
ENSG00000103496 E022 350.6856096 0.0045430978 4.260968e-01 5.689594e-01 16 31034462 31034536 75 + 2.469 2.504 0.116
ENSG00000103496 E023 101.9476549 0.0003900422 9.127979e-15 3.021084e-13 16 31034537 31034877 341 + 1.678 2.034 1.199
ENSG00000103496 E024 337.1687841 0.0003956637 4.338080e-02 9.725758e-02 16 31034970 31035040 71 + 2.507 2.470 -0.123
ENSG00000103496 E025 0.5117906 0.2510100763 2.740727e-01 4.131799e-01 16 31035699 31035761 63 + 0.297 0.086 -2.158
ENSG00000103496 E026 466.4171343 0.0001858973 3.965532e-02 9.038889e-02 16 31037926 31038034 109 + 2.641 2.612 -0.097
ENSG00000103496 E027 421.5995398 0.0006575110 5.545055e-01 6.834704e-01 16 31038114 31038190 77 + 2.579 2.574 -0.018
ENSG00000103496 E028 420.0555592 0.0001615242 7.049362e-01 8.033738e-01 16 31038510 31038600 91 + 2.574 2.574 0.002
ENSG00000103496 E029 242.3911933 0.0002170006 2.673974e-01 4.057057e-01 16 31038601 31038618 18 + 2.349 2.329 -0.067
ENSG00000103496 E030 298.5693114 0.0011772314 3.085977e-01 4.508762e-01 16 31038619 31038647 29 + 2.439 2.418 -0.073
ENSG00000103496 E031 1.8391426 0.0075406452 8.384723e-01 8.990200e-01 16 31039080 31039278 199 + 0.393 0.435 0.228
ENSG00000103496 E032 0.9244034 0.0143554715 6.125320e-01 7.314500e-01 16 31039320 31039437 118 + 0.173 0.270 0.815
ENSG00000103496 E033 473.0270717 0.0013295984 7.620921e-01 8.457783e-01 16 31039541 31039651 111 + 2.614 2.627 0.044
ENSG00000103496 E034 17.6854280 0.0010459723 4.832246e-01 6.212620e-01 16 31039652 31039722 71 + 1.260 1.207 -0.187
ENSG00000103496 E035 169.5623672 0.0095437668 1.842620e-01 3.065833e-01 16 31039723 31039725 3 + 2.120 2.202 0.274
ENSG00000103496 E036 344.2860822 0.0053566905 5.763747e-02 1.225711e-01 16 31039726 31039818 93 + 2.423 2.508 0.284
ENSG00000103496 E037 4.7755150 0.0362376359 2.007220e-02 5.163935e-02 16 31039819 31039911 93 + 0.947 0.602 -1.390
ENSG00000103496 E038 353.5892635 0.0028416054 1.888987e-01 3.123744e-01 16 31039912 31040375 464 + 2.462 2.512 0.168
ENSG00000103496 E039 11.8147418 0.0017137640 1.289489e-04 6.542837e-04 16 31040422 31040462 41 + 1.294 0.932 -1.306
ENSG00000103496 E040 12.5461627 0.0014022293 8.254560e-03 2.442852e-02 16 31041004 31041141 138 + 1.248 1.003 -0.882
ENSG00000103496 E041 5.7861197 0.0027857313 7.359327e-02 1.492754e-01 16 31041891 31041893 3 + 0.947 0.725 -0.866
ENSG00000103496 E042 14.9914557 0.0012286684 7.484318e-04 3.073065e-03 16 31041894 31042027 134 + 1.345 1.055 -1.028
ENSG00000103496 E043 59.4146578 0.0090383383 3.038494e-05 1.805513e-04 16 31042142 31043031 890 + 1.904 1.638 -0.897