ENSG00000103429

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261658 ENSG00000103429 HEK293_OSMI2_2hA HEK293_TMG_2hB BFAR protein_coding protein_coding 34.85069 21.88626 46.25255 4.826986 1.621826 1.079161 19.034940 13.0184686 22.866421 3.1045866 0.6150016 0.8121939 0.54617500 0.5902333 0.4959333 -0.09430000 9.055772e-02 6.908852e-09 FALSE  
ENST00000562442 ENSG00000103429 HEK293_OSMI2_2hA HEK293_TMG_2hB BFAR protein_coding protein_coding 34.85069 21.88626 46.25255 4.826986 1.621826 1.079161 7.050347 5.4791775 8.770765 0.6153432 0.5112579 0.6777566 0.21345000 0.2618667 0.1898000 -0.07206667 1.898077e-01 6.908852e-09 FALSE  
MSTRG.12113.1 ENSG00000103429 HEK293_OSMI2_2hA HEK293_TMG_2hB BFAR protein_coding   34.85069 21.88626 46.25255 4.826986 1.621826 1.079161 2.380789 0.4950799 4.762252 0.1397391 0.5290728 3.2400866 0.06110417 0.0228000 0.1025333 0.07973333 6.908852e-09 6.908852e-09 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103429 E001 9.9728023 0.0017206906 7.314868e-03 2.203708e-02 16 14632758 14632930 173 + 1.135 0.850 -1.057
ENSG00000103429 E002 9.6740378 0.0017748537 1.167404e-02 3.275540e-02 16 14632931 14632931 1 + 1.120 0.850 -1.000
ENSG00000103429 E003 31.8599210 0.0019272151 3.976520e-04 1.765216e-03 16 14632932 14632942 11 + 1.593 1.365 -0.787
ENSG00000103429 E004 42.5948448 0.0006406824 1.220246e-02 3.401738e-02 16 14632943 14632950 8 + 1.686 1.559 -0.432
ENSG00000103429 E005 73.6938791 0.0080217454 1.807202e-03 6.621838e-03 16 14632951 14632973 23 + 1.937 1.740 -0.664
ENSG00000103429 E006 121.6569563 0.0046879114 6.260035e-02 1.310277e-01 16 14632974 14633018 45 + 2.118 2.030 -0.295
ENSG00000103429 E007 0.4407149 0.0217681645 1.000000e+00 1.000000e+00 16 14633163 14633483 321 + 0.172 0.157 -0.165
ENSG00000103429 E008 107.2108170 0.0042133667 7.372728e-02 1.494912e-01 16 14644274 14644287 14 + 2.062 1.980 -0.275
ENSG00000103429 E009 385.3002647 0.0002566009 5.324188e-05 2.979416e-04 16 14644288 14644609 322 + 2.610 2.546 -0.213
ENSG00000103429 E010 252.7564745 0.0002628556 2.713195e-02 6.626701e-02 16 14648388 14648543 156 + 2.419 2.381 -0.125
ENSG00000103429 E011 175.3047878 0.0002534508 5.488827e-01 6.786991e-01 16 14648544 14648592 49 + 2.248 2.245 -0.009
ENSG00000103429 E012 230.0834198 0.0002216203 6.558781e-01 7.656963e-01 16 14649804 14649973 170 + 2.353 2.377 0.079
ENSG00000103429 E013 107.8795784 0.0021952967 1.198771e-14 3.896766e-13 16 14649974 14650589 616 + 1.879 2.194 1.055
ENSG00000103429 E014 172.1446200 0.0001970638 2.962905e-01 4.374939e-01 16 14655066 14655210 145 + 2.244 2.229 -0.049
ENSG00000103429 E015 153.1723803 0.0045995534 9.029787e-01 9.422665e-01 16 14661892 14661963 72 + 2.183 2.191 0.026
ENSG00000103429 E016 166.4723986 0.0003085367 1.716830e-01 2.904106e-01 16 14661964 14662029 66 + 2.234 2.210 -0.082
ENSG00000103429 E017 154.5676474 0.0002247342 7.088130e-02 1.448086e-01 16 14662030 14662065 36 + 2.206 2.167 -0.130
ENSG00000103429 E018 269.1270690 0.0002227417 8.482251e-01 9.057503e-01 16 14664869 14665071 203 + 2.428 2.437 0.032
ENSG00000103429 E019 2.8988228 0.0991305679 2.598764e-01 3.973464e-01 16 14665072 14665181 110 + 0.669 0.435 -1.086
ENSG00000103429 E020 4.0578093 0.0038147625 8.332051e-01 8.954911e-01 16 14667320 14667634 315 + 0.711 0.691 -0.081
ENSG00000103429 E021 276.1394187 0.0001775366 9.836308e-02 1.880269e-01 16 14667635 14667892 258 + 2.423 2.472 0.164
ENSG00000103429 E022 638.2861461 0.0029531214 7.977168e-04 3.251330e-03 16 14667893 14669032 1140 + 2.760 2.857 0.322
ENSG00000103429 E023 79.8235869 0.0007392402 6.007738e-04 2.535973e-03 16 14669033 14669236 204 + 1.841 1.996 0.518