ENSG00000103381

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261660 ENSG00000103381 HEK293_OSMI2_2hA HEK293_TMG_2hB CPPED1 protein_coding protein_coding 6.431524 6.632529 8.499709 0.5560675 0.4645487 0.3573772 0.1725699 0.0000000 1.1614768 0.00000000 1.1614768 6.87218459 0.02240833 0.00000000 0.12320000 0.12320000 0.88320366 0.02508897 FALSE  
ENST00000381774 ENSG00000103381 HEK293_OSMI2_2hA HEK293_TMG_2hB CPPED1 protein_coding protein_coding 6.431524 6.632529 8.499709 0.5560675 0.4645487 0.3573772 0.4052229 0.2548222 0.7783775 0.03497841 0.0782066 1.57386263 0.06032500 0.03863333 0.09223333 0.05360000 0.02508897 0.02508897 FALSE  
ENST00000433677 ENSG00000103381 HEK293_OSMI2_2hA HEK293_TMG_2hB CPPED1 protein_coding protein_coding 6.431524 6.632529 8.499709 0.5560675 0.4645487 0.3573772 1.9739113 1.9437365 1.9725252 0.19881305 0.9940282 0.02110325 0.30394583 0.29286667 0.24543333 -0.04743333 0.86294769 0.02508897 FALSE  
MSTRG.12080.2 ENSG00000103381 HEK293_OSMI2_2hA HEK293_TMG_2hB CPPED1 protein_coding   6.431524 6.632529 8.499709 0.5560675 0.4645487 0.3573772 2.3866379 3.1903054 2.8568400 1.59981704 1.4402106 -0.15874823 0.38240833 0.44826667 0.35563333 -0.09263333 0.95669509 0.02508897 TRUE  
MSTRG.12080.5 ENSG00000103381 HEK293_OSMI2_2hA HEK293_TMG_2hB CPPED1 protein_coding   6.431524 6.632529 8.499709 0.5560675 0.4645487 0.3573772 1.4847537 1.2436652 1.7304900 1.24366517 1.7304900 0.47334143 0.22962500 0.22023333 0.18353333 -0.03670000 1.00000000 0.02508897 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103381 E001 42.525657 0.0006680238 9.682445e-10 1.439465e-08 16 12659799 12663391 3593 - 1.773 1.448 -1.110
ENSG00000103381 E002 2.643573 0.0433491039 9.522209e-02 1.832076e-01 16 12663392 12663426 35 - 0.687 0.385 -1.439
ENSG00000103381 E003 3.265062 0.1101600781 1.612999e-01 2.767870e-01 16 12663427 12663486 60 - 0.760 0.445 -1.410
ENSG00000103381 E004 22.489814 0.0041157781 1.161442e-02 3.261709e-02 16 12663487 12663761 275 - 1.462 1.273 -0.657
ENSG00000103381 E005 17.299740 0.0010496990 1.286486e-01 2.322700e-01 16 12663762 12663804 43 - 1.321 1.202 -0.417
ENSG00000103381 E006 107.787836 0.0004148689 4.581539e-04 1.999214e-03 16 12663805 12664778 974 - 2.089 1.984 -0.354
ENSG00000103381 E007 16.545980 0.0027171148 1.333931e-02 3.671072e-02 16 12664779 12664782 4 - 1.130 1.342 0.746
ENSG00000103381 E008 55.774360 0.0027462229 5.068810e-04 2.186060e-03 16 12664783 12665020 238 - 1.662 1.837 0.592
ENSG00000103381 E009 42.143562 0.0005986311 2.510367e-01 3.871774e-01 16 12665021 12665115 95 - 1.605 1.668 0.213
ENSG00000103381 E010 89.639932 0.0004495376 1.353245e-01 2.415697e-01 16 12704624 12705049 426 - 1.932 1.987 0.183
ENSG00000103381 E011 0.000000       16 12780974 12781184 211 -      
ENSG00000103381 E012 75.075856 0.0030594951 1.411386e-02 3.848509e-02 16 12781185 12781403 219 - 1.827 1.938 0.374
ENSG00000103381 E013 43.338048 0.0006020004 1.346713e-02 3.700497e-02 16 12803707 12803887 181 - 1.582 1.712 0.440