ENSG00000103363

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262306 ENSG00000103363 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOB protein_coding protein_coding 905.4216 1822.425 382.8293 29.01919 13.1071 -2.251057 360.13964 751.6054 148.58035 9.952520 4.0539575 -2.338654 0.39133333 0.41246667 0.38910000 -0.023366667 0.67961857 6.506585e-07 FALSE  
ENST00000409477 ENSG00000103363 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOB protein_coding protein_coding 905.4216 1822.425 382.8293 29.01919 13.1071 -2.251057 92.47546 171.7558 41.32981 12.461808 1.5943191 -2.054839 0.10613750 0.09413333 0.10793333 0.013800000 0.41004483 6.506585e-07 FALSE  
ENST00000409906 ENSG00000103363 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOB protein_coding protein_coding 905.4216 1822.425 382.8293 29.01919 13.1071 -2.251057 51.95390 104.3246 18.93468 3.896527 0.4763261 -2.461353 0.05979583 0.05730000 0.04953333 -0.007766667 0.34170110 6.506585e-07 FALSE  
ENST00000494946 ENSG00000103363 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOB protein_coding protein_coding 905.4216 1822.425 382.8293 29.01919 13.1071 -2.251057 67.27361 154.6918 20.62392 18.221506 1.9581467 -2.906400 0.06363750 0.08506667 0.05366667 -0.031400000 0.06743695 6.506585e-07 FALSE  
ENST00000572954 ENSG00000103363 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOB protein_coding protein_coding 905.4216 1822.425 382.8293 29.01919 13.1071 -2.251057 151.33756 307.1802 58.38891 18.161781 5.0075991 -2.395119 0.16055417 0.16836667 0.15200000 -0.016366667 0.59942947 6.506585e-07    
MSTRG.11892.11 ENSG00000103363 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOB protein_coding   905.4216 1822.425 382.8293 29.01919 13.1071 -2.251057 175.84955 323.2877 90.81220 7.526825 7.4530967 -1.831746 0.20992083 0.17743333 0.23686667 0.059433333 0.03666345 6.506585e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103363 E001 4.018991 4.070785e-03 7.700415e-01 8.515228e-01 16 2771414 2771414 1 - 0.611 0.558 -0.239
ENSG00000103363 E002 416.024869 1.588125e-03 6.889614e-03 2.093841e-02 16 2771415 2771604 190 - 2.516 2.434 -0.275
ENSG00000103363 E003 499.101594 1.205771e-04 9.608598e-03 2.779963e-02 16 2771605 2771731 127 - 2.575 2.516 -0.194
ENSG00000103363 E004 612.156532 1.123197e-04 4.044087e-04 1.791554e-03 16 2771732 2771937 206 - 2.674 2.603 -0.238
ENSG00000103363 E005 230.309820 1.801123e-04 2.170138e-01 3.467955e-01 16 2771938 2771940 3 - 2.226 2.185 -0.137
ENSG00000103363 E006 261.209133 1.630166e-04 5.681500e-01 6.948468e-01 16 2771941 2771942 2 - 2.230 2.248 0.060
ENSG00000103363 E007 2387.375350 9.016874e-05 3.326292e-04 1.510876e-03 16 2771943 2771993 51 - 3.169 3.209 0.133
ENSG00000103363 E008 3383.381268 2.167490e-04 1.908166e-02 4.951598e-02 16 2771994 2772019 26 - 3.333 3.358 0.085
ENSG00000103363 E009 6596.088685 9.504520e-05 1.611593e-06 1.279434e-05 16 2772020 2772102 83 - 3.615 3.649 0.113
ENSG00000103363 E010 48.133221 4.937586e-03 8.960681e-01 9.375783e-01 16 2772103 2772122 20 - 1.533 1.525 -0.026
ENSG00000103363 E011 179.046324 2.203932e-04 8.481941e-18 4.208691e-16 16 2772140 2773748 1609 - 2.319 2.035 -0.948
ENSG00000103363 E012 47.497143 4.699120e-04 5.610586e-03 1.758008e-02 16 2773749 2773833 85 - 1.667 1.485 -0.621
ENSG00000103363 E013 149.745095 4.613197e-03 1.990352e-17 9.354162e-16 16 2773834 2775450 1617 - 2.323 1.926 -1.331
ENSG00000103363 E014 9403.109994 1.517404e-04 2.357262e-01 3.692330e-01 16 2775451 2775556 106 - 3.792 3.800 0.026
ENSG00000103363 E015 47.981912 7.939767e-04 3.416228e-01 4.855352e-01 16 2775557 2775588 32 - 1.580 1.513 -0.227
ENSG00000103363 E016 31.511136 9.123751e-04 2.423763e-01 3.769783e-01 16 2775589 2775625 37 - 1.422 1.324 -0.340
ENSG00000103363 E017 32.698539 3.924734e-02 1.518594e-05 9.679792e-05 16 2775626 2776676 1051 - 1.752 1.254 -1.712
ENSG00000103363 E018 22.502297 3.528815e-02 1.334622e-01 2.389484e-01 16 2776677 2776992 316 - 1.369 1.174 -0.684
ENSG00000103363 E019 8871.268148 1.023875e-04 9.720880e-01 9.865546e-01 16 2776993 2777127 135 - 3.774 3.773 -0.001
ENSG00000103363 E020 462.912595 4.468370e-03 1.651785e-02 4.388183e-02 16 2777128 2777195 68 - 2.572 2.478 -0.315
ENSG00000103363 E021 3289.340732 3.033577e-04 7.511559e-03 2.254396e-02 16 2777237 2777309 73 - 3.369 3.338 -0.103