ENSG00000103353

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395878 ENSG00000103353 HEK293_OSMI2_2hA HEK293_TMG_2hB UBFD1 protein_coding protein_coding 46.6317 49.06864 44.80386 3.851656 1.400799 -0.1311503 28.25307 17.59490 35.3321194 2.772115 1.0477954 1.005411 0.6134292 0.3549333 0.7889667 0.4340333 7.769698e-16 7.769698e-16 FALSE TRUE
ENST00000563366 ENSG00000103353 HEK293_OSMI2_2hA HEK293_TMG_2hB UBFD1 protein_coding processed_transcript 46.6317 49.06864 44.80386 3.851656 1.400799 -0.1311503 11.27845 26.28807 0.6707228 1.839385 0.6707228 -5.271746 0.2323542 0.5392000 0.0141000 -0.5251000 2.833508e-03 7.769698e-16 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103353 E001 1.171786 0.0115195313 3.332511e-01 4.769430e-01 16 23557549 23557623 75 + 0.198 0.453 1.670
ENSG00000103353 E002 12.731613 0.0065135052 3.520849e-03 1.178720e-02 16 23557624 23557720 97 + 1.204 1.066 -0.495
ENSG00000103353 E003 13.917116 0.0037507972 4.681707e-03 1.504504e-02 16 23557721 23557726 6 + 1.227 1.118 -0.389
ENSG00000103353 E004 20.512962 0.0079065066 5.715525e-03 1.785926e-02 16 23557727 23557736 10 + 1.371 1.287 -0.292
ENSG00000103353 E005 25.837915 0.0172045650 1.493209e-04 7.440593e-04 16 23557737 23557745 9 + 1.515 1.312 -0.700
ENSG00000103353 E006 55.995113 0.0085827109 1.174767e-11 2.417773e-10 16 23557746 23557766 21 + 1.874 1.578 -1.004
ENSG00000103353 E007 54.334351 0.0078706540 2.822591e-12 6.434544e-11 16 23557767 23557767 1 + 1.864 1.560 -1.030
ENSG00000103353 E008 4.270823 0.0038723913 1.443244e-02 3.920479e-02 16 23557768 23557949 182 + 0.812 0.595 -0.899
ENSG00000103353 E009 271.879508 0.0032702870 8.738060e-24 8.467516e-22 16 23557950 23558279 330 + 2.519 2.329 -0.634
ENSG00000103353 E010 3.016331 0.0051552939 1.555056e-01 2.690664e-01 16 23559028 23559467 440 + 0.649 0.553 -0.429
ENSG00000103353 E011 318.480629 0.0029044862 2.572787e-11 5.012410e-10 16 23559468 23559676 209 + 2.531 2.480 -0.172
ENSG00000103353 E012 6.313041 0.0826239861 2.940978e-02 7.079087e-02 16 23559779 23559868 90 + 0.958 0.710 -0.966
ENSG00000103353 E013 1.999168 0.0086887011 2.839591e-02 6.880941e-02 16 23561665 23561740 76 + 0.589 0.322 -1.389
ENSG00000103353 E014 5.423859 0.0031089670 1.183509e-01 2.175720e-01 16 23561833 23562205 373 + 0.849 0.788 -0.238
ENSG00000103353 E015 195.708209 0.0002361728 9.846362e-12 2.053461e-10 16 23562206 23562271 66 + 2.304 2.293 -0.039
ENSG00000103353 E016 272.699890 0.0001868735 9.173230e-15 3.033940e-13 16 23562625 23562730 106 + 2.443 2.437 -0.019
ENSG00000103353 E017 16.286286 0.0010874807 2.619836e-02 6.435102e-02 16 23564039 23564109 71 + 1.256 1.225 -0.108
ENSG00000103353 E018 6.221165 0.1714938492 1.121061e-01 2.086285e-01 16 23564460 23564732 273 + 0.960 0.709 -0.980
ENSG00000103353 E019 24.758116 0.0009764153 1.971621e-04 9.516618e-04 16 23564964 23566986 2023 + 1.458 1.355 -0.354
ENSG00000103353 E020 282.427150 0.0006262113 3.282636e-16 1.324006e-14 16 23566987 23567069 83 + 2.469 2.436 -0.109
ENSG00000103353 E021 5000.095023 0.0025737458 5.812091e-32 1.116717e-29 16 23570480 23574389 3910 + 3.568 3.804 0.785