ENSG00000103342

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000434724 ENSG00000103342 HEK293_OSMI2_2hA HEK293_TMG_2hB GSPT1 protein_coding protein_coding 131.9929 130.863 149.8918 3.913429 5.080887 0.1958508 12.12976 9.805049 19.73037 0.6043312 0.7738197 1.0080818 0.08979167 0.0750000 0.1316000 0.05660000 1.261806e-07 1.261806e-07 FALSE TRUE
ENST00000439887 ENSG00000103342 HEK293_OSMI2_2hA HEK293_TMG_2hB GSPT1 protein_coding protein_coding 131.9929 130.863 149.8918 3.913429 5.080887 0.1958508 27.73637 20.773916 36.71009 3.6058824 2.0773778 0.8211019 0.21044167 0.1586000 0.2464333 0.08783333 1.835834e-01 1.261806e-07 FALSE TRUE
ENST00000563468 ENSG00000103342 HEK293_OSMI2_2hA HEK293_TMG_2hB GSPT1 protein_coding protein_coding 131.9929 130.863 149.8918 3.913429 5.080887 0.1958508 88.95497 98.865693 91.03128 4.4566870 6.1654350 -0.1190951 0.67652500 0.7553333 0.6059000 -0.14943333 4.613979e-03 1.261806e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103342 E001 1610.110973 6.047983e-03 2.857784e-07 2.656650e-06 16 11868128 11872678 4551 - 3.300 3.103 -0.656
ENSG00000103342 E002 70.006004 3.840409e-04 9.595132e-02 1.843130e-01 16 11872679 11872681 3 - 1.820 1.881 0.206
ENSG00000103342 E003 72.699822 3.595413e-04 5.652011e-02 1.206337e-01 16 11872682 11872683 2 - 1.830 1.900 0.236
ENSG00000103342 E004 1992.982739 3.055775e-03 2.588853e-15 9.281802e-14 16 11872684 11873118 435 - 3.184 3.382 0.659
ENSG00000103342 E005 777.532956 2.012247e-03 3.315095e-14 1.010027e-12 16 11873119 11873171 53 - 2.787 2.968 0.601
ENSG00000103342 E006 1225.926396 5.242865e-04 2.891923e-26 3.520991e-24 16 11875761 11875929 169 - 3.007 3.152 0.484
ENSG00000103342 E007 900.014691 1.247180e-04 6.520843e-28 9.157555e-26 16 11876086 11876171 86 - 2.882 3.011 0.430
ENSG00000103342 E008 477.508067 1.507488e-04 4.620339e-08 5.018112e-07 16 11876172 11876175 4 - 2.634 2.717 0.277
ENSG00000103342 E009 1320.429033 9.155942e-05 1.285924e-10 2.228045e-09 16 11877407 11877580 174 - 3.090 3.147 0.189
ENSG00000103342 E010 1.881174 2.340434e-01 2.829609e-01 4.230312e-01 16 11880225 11880271 47 - 0.288 0.543 1.403
ENSG00000103342 E011 1014.550203 9.466946e-05 1.952228e-04 9.433827e-04 16 11883015 11883095 81 - 2.989 3.023 0.113
ENSG00000103342 E012 1024.832118 9.602569e-05 1.174678e-01 2.163348e-01 16 11885181 11885274 94 - 3.007 3.015 0.028
ENSG00000103342 E013 1250.746881 9.130025e-05 1.090860e-01 2.041956e-01 16 11886471 11886611 141 - 3.112 3.085 -0.089
ENSG00000103342 E014 1313.257152 4.747595e-04 1.934744e-01 3.181393e-01 16 11886777 11886931 155 - 3.133 3.104 -0.097
ENSG00000103342 E015 1.915545 2.650644e-02 8.743572e-01 9.232264e-01 16 11886932 11886961 30 - 0.459 0.481 0.110
ENSG00000103342 E016 728.495172 5.451161e-04 5.848773e-03 1.821523e-02 16 11887570 11887606 37 - 2.892 2.834 -0.193
ENSG00000103342 E017 1196.629298 3.872821e-04 2.805525e-04 1.300588e-03 16 11887607 11887750 144 - 3.108 3.048 -0.200
ENSG00000103342 E018 3.815613 7.119554e-03 1.807017e-02 4.728044e-02 16 11890793 11891061 269 - 0.842 0.481 -1.552
ENSG00000103342 E019 893.328296 4.960822e-04 4.910087e-06 3.501209e-05 16 11891062 11891139 78 - 2.993 2.910 -0.274
ENSG00000103342 E020 674.706331 1.908881e-03 1.479982e-04 7.384010e-04 16 11894954 11894987 34 - 2.882 2.777 -0.351
ENSG00000103342 E021 6.714433 2.017704e-02 4.096971e-02 9.282531e-02 16 11894988 11895284 297 - 1.017 0.731 -1.099
ENSG00000103342 E022 756.833928 1.949494e-03 2.151773e-03 7.695227e-03 16 11896558 11896615 58 - 2.924 2.836 -0.290
ENSG00000103342 E023 1003.805294 2.326316e-04 8.576781e-19 4.780363e-17 16 11896616 11896782 167 - 3.064 2.938 -0.418
ENSG00000103342 E024 278.109128 2.881461e-03 5.596891e-07 4.905909e-06 16 11896783 11896785 3 - 2.531 2.349 -0.606
ENSG00000103342 E025 387.805116 3.843510e-03 1.463586e-05 9.360337e-05 16 11897840 11897881 42 - 2.667 2.503 -0.548
ENSG00000103342 E026 1.855152 6.688827e-02 9.286107e-01 9.590717e-01 16 11897882 11897888 7 - 0.460 0.432 -0.143
ENSG00000103342 E027 291.373100 7.621789e-03 1.997584e-05 1.239312e-04 16 11897994 11898035 42 - 2.564 2.351 -0.712
ENSG00000103342 E028 1.627364 8.539935e-03 6.387894e-01 7.523623e-01 16 11914989 11915368 380 - 0.459 0.372 -0.472
ENSG00000103342 E029 830.888228 9.038697e-03 2.436174e-05 1.482052e-04 16 11915369 11916041 673 - 3.017 2.808 -0.696
ENSG00000103342 E030 3.730089 9.059820e-03 4.265729e-02 9.591813e-02 16 11916042 11916563 522 - 0.801 0.482 -1.386