ENSG00000103335

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301015 ENSG00000103335 HEK293_OSMI2_2hA HEK293_TMG_2hB PIEZO1 protein_coding protein_coding 47.99891 72.96229 37.68372 8.160037 2.629381 -0.9530247 12.819979 15.205932 13.3298969 2.0792536 0.4263543 -0.1898352 0.28998750 0.21013333 0.35673333 0.1466000 1.619588e-02 1.247769e-23 FALSE TRUE
ENST00000419505 ENSG00000103335 HEK293_OSMI2_2hA HEK293_TMG_2hB PIEZO1 protein_coding nonsense_mediated_decay 47.99891 72.96229 37.68372 8.160037 2.629381 -0.9530247 3.750437 9.945621 0.7144324 0.5257101 0.5077740 -3.7805884 0.06433333 0.13970000 0.02116667 -0.1185333 1.243792e-01 1.247769e-23 FALSE TRUE
ENST00000472168 ENSG00000103335 HEK293_OSMI2_2hA HEK293_TMG_2hB PIEZO1 protein_coding retained_intron 47.99891 72.96229 37.68372 8.160037 2.629381 -0.9530247 5.445745 13.695401 1.4114651 1.7619198 0.1645398 -3.2692940 0.09402917 0.18706667 0.03836667 -0.1487000 1.033020e-13 1.247769e-23 FALSE FALSE
ENST00000484567 ENSG00000103335 HEK293_OSMI2_2hA HEK293_TMG_2hB PIEZO1 protein_coding retained_intron 47.99891 72.96229 37.68372 8.160037 2.629381 -0.9530247 6.657623 5.210477 6.4959856 0.6861865 0.5636351 0.3175860 0.15154583 0.07113333 0.17203333 0.1009000 6.178239e-18 1.247769e-23 FALSE TRUE
ENST00000490756 ENSG00000103335 HEK293_OSMI2_2hA HEK293_TMG_2hB PIEZO1 protein_coding retained_intron 47.99891 72.96229 37.68372 8.160037 2.629381 -0.9530247 3.395711 2.403956 3.8530324 0.5409976 0.3062946 0.6783343 0.08269583 0.03310000 0.10320000 0.0701000 1.029271e-03 1.247769e-23   FALSE
ENST00000497793 ENSG00000103335 HEK293_OSMI2_2hA HEK293_TMG_2hB PIEZO1 protein_coding retained_intron 47.99891 72.96229 37.68372 8.160037 2.629381 -0.9530247 3.540029 2.458450 3.8006736 0.3874003 0.4235922 0.6264407 0.08215000 0.03376667 0.10046667 0.0667000 4.683047e-07 1.247769e-23 FALSE TRUE
ENST00000518793 ENSG00000103335 HEK293_OSMI2_2hA HEK293_TMG_2hB PIEZO1 protein_coding protein_coding 47.99891 72.96229 37.68372 8.160037 2.629381 -0.9530247 3.500426 10.186281 0.2332802 1.7309058 0.2332802 -5.3892805 0.05236667 0.14010000 0.00570000 -0.1344000 8.914847e-03 1.247769e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103335 E001 0.6643356 0.6269117313 3.742939e-01 5.187150e-01 16 88715338 88715342 5 - 0.000 0.284 10.870
ENSG00000103335 E002 0.8857808 0.8340338374 3.931427e-01 5.370340e-01 16 88715343 88715345 3 - 0.000 0.356 11.660
ENSG00000103335 E003 124.4140164 0.0084128627 1.105311e-11 2.286501e-10 16 88715346 88715448 103 - 1.789 2.200 1.382
ENSG00000103335 E004 171.9278125 0.0106931201 7.169240e-11 1.296108e-09 16 88715449 88715490 42 - 1.934 2.340 1.357
ENSG00000103335 E005 522.5339077 0.0057488587 4.911377e-13 1.266257e-11 16 88715491 88715815 325 - 2.490 2.799 1.029
ENSG00000103335 E006 226.4377321 0.0042761402 3.292197e-08 3.677892e-07 16 88715816 88715854 39 - 2.172 2.418 0.824
ENSG00000103335 E007 217.9747390 0.0014135750 3.274311e-16 1.320929e-14 16 88715933 88715970 38 - 2.131 2.407 0.923
ENSG00000103335 E008 146.1902281 0.0005035336 1.297970e-13 3.633223e-12 16 88715971 88715977 7 - 1.971 2.230 0.868
ENSG00000103335 E009 321.6821495 0.0022747949 2.442085e-14 7.583112e-13 16 88715978 88716096 119 - 2.316 2.574 0.860
ENSG00000103335 E010 187.8343012 0.0003055747 9.710272e-16 3.671820e-14 16 88716097 88716119 23 - 2.092 2.335 0.814
ENSG00000103335 E011 5.1982576 0.0031987544 5.979438e-01 7.196271e-01 16 88716120 88716197 78 - 0.822 0.762 -0.237
ENSG00000103335 E012 278.3512976 0.0013426613 7.375128e-16 2.835794e-14 16 88716198 88716277 80 - 2.260 2.508 0.829
ENSG00000103335 E013 330.7658580 0.0029034973 2.684150e-12 6.145809e-11 16 88716361 88716483 123 - 2.332 2.585 0.843
ENSG00000103335 E014 387.4178679 0.0021648835 2.119463e-13 5.751695e-12 16 88716559 88716731 173 - 2.415 2.649 0.780
ENSG00000103335 E015 6.4161744 0.0352444014 6.985505e-01 7.984849e-01 16 88716732 88716792 61 - 0.869 0.828 -0.159
ENSG00000103335 E016 300.4379235 0.0012045807 1.065769e-12 2.602056e-11 16 88716806 88716898 93 - 2.322 2.531 0.699
ENSG00000103335 E017 408.3173858 0.0064385431 6.472433e-04 2.706268e-03 16 88717023 88717211 189 - 2.490 2.655 0.549
ENSG00000103335 E018 93.9615377 0.0052187056 2.753433e-04 1.279319e-03 16 88717212 88717536 325 - 2.059 1.890 -0.568
ENSG00000103335 E019 68.3422563 0.0099890837 7.070662e-01 8.050784e-01 16 88717537 88717615 79 - 1.832 1.822 -0.034
ENSG00000103335 E020 31.2225033 0.0045545233 7.350545e-05 3.969835e-04 16 88717616 88717714 99 - 1.635 1.372 -0.900
ENSG00000103335 E021 26.6241581 0.0072354627 2.113932e-02 5.389289e-02 16 88717715 88717808 94 - 1.523 1.356 -0.576
ENSG00000103335 E022 119.3818114 0.0020940723 7.796864e-15 2.606021e-13 16 88717809 88718741 933 - 2.216 1.926 -0.972
ENSG00000103335 E023 74.0591256 0.0004949042 4.543241e-08 4.941743e-07 16 88718972 88719573 602 - 1.976 1.759 -0.732
ENSG00000103335 E024 304.8042464 0.0031925455 6.658475e-04 2.773589e-03 16 88719574 88719721 148 - 2.382 2.517 0.449
ENSG00000103335 E025 282.5306295 0.0004319223 6.053983e-04 2.553112e-03 16 88719802 88719960 159 - 2.375 2.469 0.313
ENSG00000103335 E026 287.8487482 0.0001740321 2.959297e-01 4.370735e-01 16 88720069 88720283 215 - 2.419 2.454 0.116
ENSG00000103335 E027 25.0488008 0.0380163835 2.080724e-01 3.361701e-01 16 88720284 88720384 101 - 1.478 1.338 -0.484
ENSG00000103335 E028 226.4869702 0.0002796764 5.349477e-01 6.669096e-01 16 88720385 88720532 148 - 2.322 2.350 0.091
ENSG00000103335 E029 193.7861278 0.0001944338 1.933482e-01 3.179886e-01 16 88720616 88720748 133 - 2.242 2.289 0.155
ENSG00000103335 E030 290.4948174 0.0016603559 8.230493e-01 8.884672e-01 16 88721166 88721430 265 - 2.434 2.455 0.072
ENSG00000103335 E031 213.0932459 0.0019775979 7.492048e-01 8.362129e-01 16 88721538 88721673 136 - 2.301 2.324 0.077
ENSG00000103335 E032 111.7762817 0.0009201329 6.924995e-01 7.937318e-01 16 88721674 88721726 53 - 2.020 2.046 0.088
ENSG00000103335 E033 223.7472585 0.0001794019 4.212344e-01 5.643661e-01 16 88721808 88722066 259 - 2.314 2.345 0.105
ENSG00000103335 E034 169.9377856 0.0004320708 2.148864e-01 3.443049e-01 16 88722218 88722397 180 - 2.227 2.203 -0.080
ENSG00000103335 E035 1.1941248 0.3716929354 2.920308e-01 4.329589e-01 16 88722523 88722582 60 - 0.461 0.201 -1.683
ENSG00000103335 E036 143.0407181 0.0002412621 2.285189e-02 5.743045e-02 16 88722583 88722689 107 - 2.175 2.117 -0.193
ENSG00000103335 E037 147.2563971 0.0002258493 1.055887e-02 3.011118e-02 16 88722837 88722981 145 - 2.193 2.128 -0.217
ENSG00000103335 E038 91.3560211 0.0003163449 5.640507e-01 6.914341e-01 16 88722982 88723009 28 - 1.951 1.941 -0.035
ENSG00000103335 E039 110.8617111 0.0002560592 5.777978e-02 1.228200e-01 16 88723095 88723151 57 - 2.062 2.008 -0.180
ENSG00000103335 E040 151.9773898 0.0002551845 1.627139e-04 8.036932e-04 16 88723226 88723328 103 - 2.224 2.125 -0.333
ENSG00000103335 E041 144.6830794 0.0002914192 4.261470e-04 1.874748e-03 16 88723871 88723946 76 - 2.200 2.105 -0.319
ENSG00000103335 E042 92.5221956 0.0033906625 3.878577e-03 1.280269e-02 16 88723947 88723971 25 - 2.022 1.903 -0.400
ENSG00000103335 E043 108.7692347 0.0022334587 2.774799e-02 6.751397e-02 16 88725009 88725080 72 - 2.066 1.990 -0.254
ENSG00000103335 E044 135.1006456 0.0010731307 6.206281e-03 1.915789e-02 16 88725416 88725519 104 - 2.163 2.082 -0.271
ENSG00000103335 E045 137.0302108 0.0034365085 1.737919e-03 6.401408e-03 16 88725595 88725684 90 - 2.187 2.073 -0.379
ENSG00000103335 E046 1.3619978 0.0101029931 6.603598e-01 7.690328e-01 16 88725685 88726025 341 - 0.399 0.328 -0.415
ENSG00000103335 E047 185.1445045 0.0013497775 5.947166e-04 2.513884e-03 16 88726284 88726455 172 - 2.305 2.212 -0.311
ENSG00000103335 E048 123.6513154 0.0037020628 1.110286e-01 2.070530e-01 16 88726547 88726643 97 - 2.109 2.057 -0.175
ENSG00000103335 E049 202.6255870 0.0002327026 4.074300e-04 1.803168e-03 16 88726715 88726958 244 - 2.336 2.257 -0.265
ENSG00000103335 E050 73.6556229 0.0003356955 8.339538e-02 1.648838e-01 16 88727039 88727054 16 - 1.890 1.829 -0.206
ENSG00000103335 E051 141.4353551 0.0002769576 5.226236e-04 2.244248e-03 16 88727055 88727192 138 - 2.190 2.095 -0.316
ENSG00000103335 E052 124.3633318 0.0015591071 2.246620e-04 1.069010e-03 16 88727557 88727661 105 - 2.152 2.030 -0.411
ENSG00000103335 E053 1.5457654 0.0378616646 8.948851e-01 9.368188e-01 16 88727662 88727843 182 - 0.399 0.383 -0.089
ENSG00000103335 E054 154.8346641 0.0060401591 1.313479e-03 5.022195e-03 16 88731706 88731910 205 - 2.252 2.121 -0.439
ENSG00000103335 E055 107.7108713 0.0011213662 5.473270e-03 1.721701e-02 16 88732335 88732463 129 - 2.070 1.979 -0.308
ENSG00000103335 E056 83.1311616 0.0031254708 1.663342e-01 2.834305e-01 16 88732464 88732535 72 - 1.936 1.886 -0.170
ENSG00000103335 E057 124.9939516 0.0042788743 1.045626e-02 2.987839e-02 16 88732607 88732732 126 - 2.143 2.044 -0.332
ENSG00000103335 E058 33.7082775 0.0057735538 3.063518e-06 2.287370e-05 16 88732733 88733073 341 - 1.688 1.374 -1.076
ENSG00000103335 E059 144.1458975 0.0004672559 2.902696e-07 2.694521e-06 16 88733278 88733454 177 - 2.227 2.081 -0.491
ENSG00000103335 E060 111.5451037 0.0011239015 7.474650e-03 2.244883e-02 16 88733588 88733745 158 - 2.081 1.995 -0.288
ENSG00000103335 E061 104.1975190 0.0003134812 3.243203e-04 1.478096e-03 16 88733906 88734054 149 - 2.070 1.955 -0.388
ENSG00000103335 E062 144.1301758 0.0054155625 4.434802e-04 1.941669e-03 16 88734356 88734538 183 - 2.227 2.084 -0.479
ENSG00000103335 E063 154.3314824 0.0063905808 4.003568e-06 2.912240e-05 16 88734650 88734798 149 - 2.289 2.087 -0.678
ENSG00000103335 E064 159.0570439 0.0111493428 7.053994e-05 3.827132e-04 16 88734875 88735053 179 - 2.306 2.096 -0.703
ENSG00000103335 E065 103.9777067 0.0254835635 3.162621e-03 1.074514e-02 16 88735135 88735246 112 - 2.134 1.902 -0.780
ENSG00000103335 E066 134.5132670 0.0133777413 1.670850e-03 6.189384e-03 16 88736148 88736408 261 - 2.219 2.039 -0.602
ENSG00000103335 E067 2.1974353 0.1373214537 1.029145e-03 4.059049e-03 16 88736531 88736638 108 - 0.795 0.107 -4.230
ENSG00000103335 E068 61.5785848 0.0247058356 2.391823e-02 5.963663e-02 16 88736639 88736739 101 - 1.882 1.708 -0.588
ENSG00000103335 E069 71.5552822 0.0095810138 3.586295e-06 2.639419e-05 16 88737559 88737646 88 - 1.995 1.718 -0.934
ENSG00000103335 E070 79.2436985 0.0019956152 1.460753e-09 2.099023e-08 16 88737728 88737814 87 - 2.025 1.767 -0.868
ENSG00000103335 E071 99.7211611 0.0028593321 3.902599e-11 7.374184e-10 16 88737934 88738105 172 - 2.134 1.859 -0.923
ENSG00000103335 E072 111.8030015 0.0083760420 2.631540e-08 2.997458e-07 16 88738227 88738440 214 - 2.197 1.900 -0.995
ENSG00000103335 E073 94.7543501 0.0088733941 2.399954e-10 3.964634e-09 16 88738568 88738736 169 - 2.151 1.795 -1.196
ENSG00000103335 E074 89.5133131 0.0046320665 1.116496e-17 5.445850e-16 16 88741478 88741616 139 - 2.151 1.734 -1.403
ENSG00000103335 E075 59.1149905 0.0004944163 4.489407e-23 4.015603e-21 16 88742053 88742095 43 - 1.983 1.531 -1.529
ENSG00000103335 E076 66.6060442 0.0044229084 1.350623e-16 5.720355e-15 16 88742300 88742422 123 - 2.029 1.594 -1.471
ENSG00000103335 E077 38.0763200 0.0147672765 8.179545e-09 1.024986e-07 16 88749384 88749479 96 - 1.803 1.342 -1.576
ENSG00000103335 E078 0.0000000       16 88773995 88774057 63 -      
ENSG00000103335 E079 35.2390959 0.0540645208 2.788158e-06 2.102070e-05 16 88784901 88785220 320 - 1.806 1.235 -1.961