ENSG00000103274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000283027 ENSG00000103274 HEK293_OSMI2_2hA HEK293_TMG_2hB NUBP1 protein_coding protein_coding 28.17594 41.87683 27.30525 4.266681 1.114835 -0.61679 22.071079 32.365237 20.242945 3.8591066 0.6891604 -0.6767590 0.7844792 0.77020000 0.7422667 -0.02793333 0.72722371 0.001544 FALSE  
ENST00000574334 ENSG00000103274 HEK293_OSMI2_2hA HEK293_TMG_2hB NUBP1 protein_coding protein_coding 28.17594 41.87683 27.30525 4.266681 1.114835 -0.61679 2.452243 3.044894 3.810074 0.3903976 0.5282545 0.3224779 0.0883875 0.07303333 0.1391333 0.06610000 0.01806692 0.001544 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103274 E001 0.000000       16 10743134 10743785 652 +      
ENSG00000103274 E002 14.464905 0.0085390778 0.008506240 0.025053898 16 10743786 10743840 55 + 1.313 1.061 -0.898
ENSG00000103274 E003 15.090445 0.0057340244 0.009492900 0.027519110 16 10743841 10743841 1 + 1.322 1.087 -0.834
ENSG00000103274 E004 16.821038 0.0038492663 0.002005835 0.007244514 16 10743842 10743843 2 + 1.381 1.120 -0.918
ENSG00000103274 E005 29.102663 0.0010126531 0.003946434 0.012992044 16 10743844 10743854 11 + 1.564 1.383 -0.622
ENSG00000103274 E006 95.241909 0.0003342863 0.334104056 0.477855086 16 10743855 10743882 28 + 1.979 1.951 -0.093
ENSG00000103274 E007 1.706645 0.1232337739 0.270129389 0.408714978 16 10743883 10743960 78 + 0.557 0.342 -1.123
ENSG00000103274 E008 168.597459 0.0002599804 0.226033905 0.357635318 16 10743961 10744065 105 + 2.223 2.197 -0.087
ENSG00000103274 E009 276.855604 0.0002621145 0.352821239 0.497083194 16 10747143 10747276 134 + 2.427 2.415 -0.042
ENSG00000103274 E010 206.346086 0.0028879494 0.930987669 0.960560319 16 10752610 10752678 69 + 2.289 2.288 -0.001
ENSG00000103274 E011 149.984060 0.0002171533 0.691554675 0.793008647 16 10755721 10755753 33 + 2.141 2.161 0.068
ENSG00000103274 E012 226.859340 0.0002430883 0.078993471 0.157902760 16 10756690 10756780 91 + 2.357 2.323 -0.114
ENSG00000103274 E013 269.108054 0.0001693165 0.024113074 0.060044027 16 10757873 10758010 138 + 2.434 2.393 -0.136
ENSG00000103274 E014 146.521396 0.0002333698 0.768018393 0.850112113 16 10758011 10758027 17 + 2.134 2.151 0.058
ENSG00000103274 E015 224.880918 0.0002038867 0.084776464 0.167051308 16 10761364 10761474 111 + 2.294 2.345 0.169
ENSG00000103274 E016 206.647869 0.0023214288 0.030333814 0.072624734 16 10761757 10761859 103 + 2.236 2.314 0.261
ENSG00000103274 E017 3.098969 0.0966794542 0.524438672 0.657963624 16 10761860 10762112 253 + 0.502 0.621 0.547
ENSG00000103274 E018 1.678279 0.3055692616 0.536989388 0.668648372 16 10763541 10763834 294 + 0.500 0.352 -0.793
ENSG00000103274 E019 1.401650 0.0095207230 0.525937850 0.659240875 16 10765024 10765144 121 + 0.272 0.391 0.751
ENSG00000103274 E020 198.764746 0.0025329065 0.111558807 0.207846114 16 10767949 10768032 84 + 2.232 2.292 0.198
ENSG00000103274 E021 254.095297 0.0040483438 0.022176427 0.056038436 16 10769047 10769351 305 + 2.317 2.406 0.296