ENSG00000103222

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399410 ENSG00000103222 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCC1 protein_coding protein_coding 19.61303 22.60038 16.12257 1.852873 0.4119935 -0.4870095 10.3300640 7.9279287 10.9443028 0.7950911 0.3388293 0.4646632 0.54962500 0.35206667 0.67886667 0.326800000 1.379166e-09 1.119024e-22 FALSE TRUE
ENST00000572882 ENSG00000103222 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCC1 protein_coding protein_coding 19.61303 22.60038 16.12257 1.852873 0.4119935 -0.4870095 0.9718313 0.6820149 1.1882265 0.4317084 0.1975356 0.7920257 0.05106250 0.03106667 0.07420000 0.043133333 2.498530e-01 1.119024e-22 FALSE TRUE
ENST00000574761 ENSG00000103222 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCC1 protein_coding retained_intron 19.61303 22.60038 16.12257 1.852873 0.4119935 -0.4870095 1.6688931 2.3411703 1.5610743 0.6102305 0.2634073 -0.5816277 0.08227083 0.10076667 0.09613333 -0.004633333 9.715693e-01 1.119024e-22 FALSE TRUE
ENST00000676806 ENSG00000103222 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCC1 protein_coding processed_transcript 19.61303 22.60038 16.12257 1.852873 0.4119935 -0.4870095 3.8793765 9.9616817 0.0000000 1.6870196 0.0000000 -9.9616930 0.17229583 0.44063333 0.00000000 -0.440633333 1.119024e-22 1.119024e-22 FALSE TRUE
MSTRG.12147.8 ENSG00000103222 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCC1 protein_coding   19.61303 22.60038 16.12257 1.852873 0.4119935 -0.4870095 0.9771302 0.7979651 0.9485976 0.2121846 0.4783548 0.2466323 0.05067500 0.03633333 0.05836667 0.022033333 1.000000e+00 1.119024e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103222 E001 0.1472490 0.0428544533 4.570885e-01   16 15949138 15949260 123 + 0.121 0.000 -13.304
ENSG00000103222 E002 1.4684513 0.0212317644 3.554140e-04 1.601011e-03 16 15949577 15949615 39 + 0.623 0.000 -16.630
ENSG00000103222 E003 6.0422725 0.0221241622 3.920106e-12 8.722234e-11 16 15949616 15949656 41 + 1.150 0.000 -18.665
ENSG00000103222 E004 7.9717266 0.0020851190 3.271238e-18 1.690172e-16 16 15949657 15949677 21 + 1.262 0.000 -19.064
ENSG00000103222 E005 25.8762612 0.0040141929 3.208897e-17 1.466625e-15 16 15949678 15949799 122 + 1.655 1.026 -2.200
ENSG00000103222 E006 83.8980241 0.0177593182 3.385341e-07 3.099022e-06 16 16007816 16007992 177 + 2.074 1.744 -1.111
ENSG00000103222 E007 90.1184968 0.0138043297 9.571288e-05 5.018827e-04 16 16009776 16009901 126 + 2.057 1.847 -0.705
ENSG00000103222 E008 94.8310262 0.0026108530 7.925814e-06 5.387978e-05 16 16014491 16014628 138 + 2.050 1.903 -0.492
ENSG00000103222 E009 94.2423324 0.0008465518 5.185009e-09 6.745069e-08 16 16016496 16016621 126 + 2.061 1.882 -0.600
ENSG00000103222 E010 72.0205627 0.0039015113 4.206848e-06 3.043747e-05 16 16033109 16033170 62 + 1.948 1.761 -0.632
ENSG00000103222 E011 85.5364385 0.0100697981 1.342334e-07 1.330584e-06 16 16036472 16036603 132 + 2.060 1.785 -0.925
ENSG00000103222 E012 144.4092689 0.0032247245 9.151774e-08 9.356085e-07 16 16044450 16044680 231 + 2.238 2.074 -0.548
ENSG00000103222 E013 120.8711877 0.0002483921 1.583620e-06 1.259073e-05 16 16045836 16046013 178 + 2.137 2.028 -0.367
ENSG00000103222 E014 119.2961054 0.0002779476 4.486526e-05 2.556959e-04 16 16048142 16048303 162 + 2.120 2.033 -0.293
ENSG00000103222 E015 104.1325034 0.0002777880 5.986146e-05 3.307736e-04 16 16052724 16052816 93 + 2.064 1.970 -0.316
ENSG00000103222 E016 139.7077296 0.0002685330 5.001072e-04 2.160486e-03 16 16056092 16056295 204 + 2.177 2.117 -0.199
ENSG00000103222 E017 0.6997360 0.0168465124 4.350506e-02 9.747963e-02 16 16056296 16057159 864 + 0.000 0.366 15.126
ENSG00000103222 E018 0.5138669 0.0204226742 5.267054e-01 6.599039e-01 16 16057431 16057571 141 + 0.215 0.124 -0.951
ENSG00000103222 E019 104.8600151 0.0057559972 5.472307e-03 1.721456e-02 16 16068156 16068302 147 + 2.070 1.979 -0.308
ENSG00000103222 E020 88.9632590 0.0006666001 4.151207e-06 3.007624e-05 16 16071642 16071729 88 + 2.018 1.885 -0.445
ENSG00000103222 E021 0.3697384 0.0249197592 2.190696e-01 3.492647e-01 16 16076174 16076325 152 + 0.000 0.221 14.127
ENSG00000103222 E022 87.7005197 0.0003343923 6.526963e-04 2.725339e-03 16 16076326 16076401 76 + 1.984 1.900 -0.283
ENSG00000103222 E023 90.8955612 0.0003296000 6.203719e-01 7.375530e-01 16 16079352 16079478 127 + 1.943 1.970 0.089
ENSG00000103222 E024 93.3528662 0.0038783260 1.343719e-01 2.402359e-01 16 16083366 16083542 177 + 1.980 1.958 -0.074
ENSG00000103222 E025 106.9966553 0.0142797970 2.889708e-01 4.296326e-01 16 16086824 16086991 168 + 2.038 2.023 -0.048
ENSG00000103222 E026 123.9576065 0.0124977248 3.429705e-01 4.870049e-01 16 16090405 16090588 184 + 2.097 2.090 -0.025
ENSG00000103222 E027 0.0000000       16 16097992 16098281 290 +      
ENSG00000103222 E028 0.2987644 0.0270534008 1.809997e-01   16 16098873 16098902 30 + 0.215 0.000 -14.309
ENSG00000103222 E029 98.3021821 0.0040380219 5.275954e-01 6.606302e-01 16 16102627 16102717 91 + 1.982 2.000 0.060
ENSG00000103222 E030 6.9563193 0.0949019385 8.061668e-01 8.767977e-01 16 16105400 16105460 61 + 0.869 0.899 0.113
ENSG00000103222 E031 8.7880394 0.0715514261 3.622597e-01 5.066517e-01 16 16106526 16106737 212 + 1.025 0.932 -0.344
ENSG00000103222 E032 123.6899090 0.0004145904 5.002189e-01 6.364850e-01 16 16106738 16106873 136 + 2.078 2.102 0.078
ENSG00000103222 E033 170.5819482 0.0002005374 3.211132e-01 4.643228e-01 16 16111375 16111582 208 + 2.219 2.237 0.061
ENSG00000103222 E034 203.2951098 0.0002674937 9.236294e-02 1.788016e-01 16 16114766 16115076 311 + 2.253 2.342 0.296
ENSG00000103222 E035 0.0000000       16 16120577 16120692 116 +      
ENSG00000103222 E036 159.1318996 0.0002068707 8.701777e-05 4.610615e-04 16 16121975 16122174 200 + 2.105 2.263 0.528
ENSG00000103222 E037 118.8497460 0.0003370801 1.768764e-03 6.499798e-03 16 16124789 16124915 127 + 1.983 2.133 0.503
ENSG00000103222 E038 119.8575524 0.0017685302 5.895813e-02 1.248529e-01 16 16125810 16125911 102 + 2.007 2.125 0.397
ENSG00000103222 E039 137.3505415 0.0048208516 3.650069e-01 5.093471e-01 16 16131789 16131935 147 + 2.085 2.174 0.298
ENSG00000103222 E040 163.0409480 0.0002155566 2.722105e-02 6.643838e-02 16 16134350 16134508 159 + 2.147 2.255 0.360
ENSG00000103222 E041 185.0877292 0.0001988249 3.196874e-01 4.627733e-01 16 16136478 16136644 167 + 2.225 2.296 0.239
ENSG00000103222 E042 185.0994583 0.0016125940 3.562535e-02 8.285596e-02 16 16138364 16138558 195 + 2.200 2.314 0.379
ENSG00000103222 E043 1080.5555942 0.0075850845 1.923493e-13 5.256021e-12 16 16141173 16143257 2085 + 2.837 3.150 1.041