ENSG00000103174

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312251 ENSG00000103174 HEK293_OSMI2_2hA HEK293_TMG_2hB NAGPA protein_coding protein_coding 21.31181 28.83601 17.53781 1.682673 0.3453908 -0.7170803 12.144607 18.030807 7.798970 1.05671748 0.17822555 -1.20805980 0.55957500 0.62550000 0.44470000 -0.18080000 2.395231e-09 2.395231e-09 FALSE TRUE
ENST00000381955 ENSG00000103174 HEK293_OSMI2_2hA HEK293_TMG_2hB NAGPA protein_coding protein_coding 21.31181 28.83601 17.53781 1.682673 0.3453908 -0.7170803 1.491040 2.776672 2.170227 0.27279218 0.19055890 -0.35406447 0.06690833 0.09643333 0.12373333 0.02730000 3.977502e-01 2.395231e-09 FALSE TRUE
ENST00000564397 ENSG00000103174 HEK293_OSMI2_2hA HEK293_TMG_2hB NAGPA protein_coding retained_intron 21.31181 28.83601 17.53781 1.682673 0.3453908 -0.7170803 1.420326 1.252426 1.333418 0.02687864 0.07239407 0.08970873 0.07143750 0.04363333 0.07593333 0.03230000 1.012284e-02 2.395231e-09 FALSE TRUE
ENST00000568202 ENSG00000103174 HEK293_OSMI2_2hA HEK293_TMG_2hB NAGPA protein_coding retained_intron 21.31181 28.83601 17.53781 1.682673 0.3453908 -0.7170803 1.622931 2.443919 1.286928 0.16801305 0.13139216 -0.91998912 0.07350417 0.08496667 0.07316667 -0.01180000 6.851149e-01 2.395231e-09 FALSE TRUE
ENST00000569793 ENSG00000103174 HEK293_OSMI2_2hA HEK293_TMG_2hB NAGPA protein_coding processed_transcript 21.31181 28.83601 17.53781 1.682673 0.3453908 -0.7170803 1.624612 1.018419 1.787766 0.32552887 0.15845703 0.80577687 0.08210833 0.03523333 0.10206667 0.06683333 2.495283e-02 2.395231e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103174 E001 2.2508119 0.0194870918 5.342996e-01 6.663724e-01 16 5024844 5024871 28 - 0.390 0.502 0.581
ENSG00000103174 E002 9.1325255 0.0019631275 2.004611e-01 3.267885e-01 16 5024872 5024900 29 - 0.834 0.988 0.582
ENSG00000103174 E003 13.5439961 0.0012918562 3.681444e-02 8.511182e-02 16 5024901 5024909 9 - 0.943 1.162 0.798
ENSG00000103174 E004 37.8689111 0.0005939566 2.568387e-03 8.968265e-03 16 5024910 5024929 20 - 1.386 1.583 0.677
ENSG00000103174 E005 289.7159808 0.0039351666 6.592172e-02 1.365748e-01 16 5024930 5025187 258 - 2.361 2.429 0.225
ENSG00000103174 E006 401.9110462 0.0014346431 7.731301e-03 2.310406e-02 16 5025188 5025549 362 - 2.504 2.570 0.218
ENSG00000103174 E007 128.0177679 0.0011382409 1.524024e-01 2.649431e-01 16 5025550 5025601 52 - 2.023 2.074 0.169
ENSG00000103174 E008 140.3264370 0.0002713002 1.018931e-01 1.933776e-01 16 5025602 5025685 84 - 2.058 2.109 0.170
ENSG00000103174 E009 159.8141600 0.0002393672 2.721803e-02 6.643442e-02 16 5027135 5027198 64 - 2.102 2.167 0.220
ENSG00000103174 E010 20.5785494 0.0009255770 4.518433e-01 5.927654e-01 16 5027199 5027277 79 - 1.231 1.291 0.210
ENSG00000103174 E011 108.7990629 0.0004070514 2.953508e-01 4.364840e-01 16 5027278 5027289 12 - 1.958 1.995 0.121
ENSG00000103174 E012 107.8751218 0.0005667124 1.472721e-01 2.579798e-01 16 5027290 5027300 11 - 1.942 1.995 0.177
ENSG00000103174 E013 111.8000488 0.0004857955 1.154946e-01 2.135644e-01 16 5027301 5027315 15 - 1.956 2.012 0.189
ENSG00000103174 E014 143.0896013 0.0008811790 7.523684e-03 2.257463e-02 16 5027316 5027379 64 - 2.033 2.125 0.310
ENSG00000103174 E015 132.3262798 0.0002393689 2.897142e-03 9.962152e-03 16 5027846 5027893 48 - 1.994 2.094 0.336
ENSG00000103174 E016 176.8373590 0.0002285031 1.292557e-01 2.331518e-01 16 5027980 5028071 92 - 2.164 2.205 0.138
ENSG00000103174 E017 146.6706779 0.0002371420 5.070755e-01 6.426971e-01 16 5028072 5028119 48 - 2.103 2.121 0.059
ENSG00000103174 E018 149.8402403 0.0002581352 7.130991e-01 8.096403e-01 16 5028120 5028185 66 - 2.137 2.121 -0.051
ENSG00000103174 E019 7.4663637 0.0527242988 2.209914e-02 5.588387e-02 16 5028186 5028296 111 - 1.118 0.760 -1.353
ENSG00000103174 E020 13.3858600 0.0013264739 3.559439e-02 8.279718e-02 16 5028297 5028365 69 - 1.243 1.043 -0.720
ENSG00000103174 E021 4.8535880 0.0038203378 3.788046e-04 1.692653e-03 16 5028366 5028398 33 - 1.010 0.531 -1.944
ENSG00000103174 E022 15.2495289 0.0011712716 3.937997e-08 4.337452e-07 16 5028399 5028879 481 - 1.450 0.978 -1.678
ENSG00000103174 E023 137.9700838 0.0002945041 1.083778e-01 2.031409e-01 16 5028880 5028945 66 - 2.129 2.073 -0.187
ENSG00000103174 E024 147.6477825 0.0004650438 5.315221e-02 1.147606e-01 16 5028946 5029008 63 - 2.165 2.100 -0.219
ENSG00000103174 E025 41.3807794 0.0008475966 8.824672e-15 2.926834e-13 16 5029009 5030158 1150 - 1.842 1.413 -1.463
ENSG00000103174 E026 5.0092549 0.0085301709 3.012860e-03 1.030340e-02 16 5030314 5030384 71 - 0.989 0.584 -1.625
ENSG00000103174 E027 126.6465026 0.0031999882 7.993602e-01 8.720168e-01 16 5030385 5030441 57 - 2.047 2.055 0.029
ENSG00000103174 E028 126.9694378 0.0015766477 5.129842e-01 6.478495e-01 16 5030442 5030493 52 - 2.037 2.059 0.075
ENSG00000103174 E029 6.2752601 0.0421736559 1.128489e-03 4.399492e-03 16 5030494 5030651 158 - 1.102 0.612 -1.914
ENSG00000103174 E030 10.1243478 0.0020815013 8.693354e-07 7.314812e-06 16 5031028 5031744 717 - 1.300 0.795 -1.856
ENSG00000103174 E031 145.3221537 0.0046328200 2.878597e-01 4.284135e-01 16 5031745 5031842 98 - 2.148 2.099 -0.163
ENSG00000103174 E032 90.9752314 0.0033238988 3.024373e-02 7.244489e-02 16 5031843 5031884 42 - 1.985 1.881 -0.352
ENSG00000103174 E033 2.7000633 0.0058294875 5.184015e-03 1.642933e-02 16 5032991 5033155 165 - 0.802 0.363 -2.031
ENSG00000103174 E034 70.8331766 0.0019036222 6.685090e-04 2.783206e-03 16 5033273 5033340 68 - 1.914 1.749 -0.558
ENSG00000103174 E035 142.0613267 0.0125246871 2.394337e-03 8.443155e-03 16 5033341 5033728 388 - 2.225 2.045 -0.602
ENSG00000103174 E036 22.2316784 0.0009308153 5.591669e-01 6.873020e-01 16 5033729 5033828 100 - 1.350 1.300 -0.172
ENSG00000103174 E037 42.8365444 0.0060120487 7.416427e-03 2.230180e-02 16 5033829 5033939 111 - 1.708 1.528 -0.613
ENSG00000103174 E038 0.3332198 0.0284421659 5.634983e-01   16 5033999 5034141 143 - 0.172 0.086 -1.156