ENSG00000103168

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000562330 ENSG00000103168 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1C protein_coding retained_intron 31.27683 28.83947 28.85913 2.842614 1.342151 0.0009830399 1.697087 0.8305515 2.1497122 0.2121471 0.1366037 1.3614309 0.05375000 0.02800000 0.07456667 0.04656667 9.384528e-05 3.951217e-35 FALSE TRUE
ENST00000564208 ENSG00000103168 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1C protein_coding retained_intron 31.27683 28.83947 28.85913 2.842614 1.342151 0.0009830399 1.796287 3.0244009 0.7970495 0.3830315 0.5307534 -1.9106827 0.05907083 0.10686667 0.02850000 -0.07836667 2.879680e-01 3.951217e-35 FALSE TRUE
ENST00000564345 ENSG00000103168 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1C protein_coding protein_coding 31.27683 28.83947 28.85913 2.842614 1.342151 0.0009830399 1.769411 1.6109070 1.8909187 0.8108173 0.3445376 0.2298955 0.05567083 0.05173333 0.06670000 0.01496667 8.124455e-01 3.951217e-35 FALSE FALSE
ENST00000564774 ENSG00000103168 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1C protein_coding retained_intron 31.27683 28.83947 28.85913 2.842614 1.342151 0.0009830399 6.505423 3.9661681 6.8482203 0.5082912 0.4648565 0.7864555 0.20512500 0.13693333 0.23683333 0.09990000 4.747798e-07 3.951217e-35 FALSE TRUE
ENST00000566732 ENSG00000103168 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1C protein_coding protein_coding 31.27683 28.83947 28.85913 2.842614 1.342151 0.0009830399 2.556864 7.1845638 0.0000000 1.2574772 0.0000000 -9.4907634 0.08571250 0.24643333 0.00000000 -0.24643333 3.951217e-35 3.951217e-35 FALSE TRUE
ENST00000567759 ENSG00000103168 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1C protein_coding protein_coding 31.27683 28.83947 28.85913 2.842614 1.342151 0.0009830399 5.597069 5.1254030 3.3937449 0.2917415 0.3770009 -0.5933546 0.17710417 0.18026667 0.11726667 -0.06300000 6.629294e-02 3.951217e-35 FALSE TRUE
ENST00000570270 ENSG00000103168 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1C protein_coding retained_intron 31.27683 28.83947 28.85913 2.842614 1.342151 0.0009830399 4.320255 2.1128278 5.3132294 0.1702548 0.2464427 1.3263144 0.13716667 0.07353333 0.18413333 0.11060000 6.452633e-15 3.951217e-35   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103168 E001 1.069579 0.0115735674 1.659074e-02 4.403842e-02 16 84177847 84177851 5 - 0.518 0.106 -3.048
ENSG00000103168 E002 1.252327 0.0105069120 2.380722e-01 3.719022e-01 16 84177852 84177853 2 - 0.464 0.263 -1.201
ENSG00000103168 E003 1.100812 0.0123019103 4.114991e-01 5.550535e-01 16 84177854 84177854 1 - 0.403 0.263 -0.879
ENSG00000103168 E004 11.645340 0.0526608628 6.159080e-01 7.340656e-01 16 84177855 84177876 22 - 1.039 1.129 0.326
ENSG00000103168 E005 530.680934 0.0022137715 1.026889e-11 2.133592e-10 16 84177877 84178748 872 - 2.577 2.773 0.653
ENSG00000103168 E006 111.196241 0.0002923772 1.873284e-02 4.874834e-02 16 84178749 84178780 32 - 1.971 2.064 0.312
ENSG00000103168 E007 186.326731 0.0032509398 1.117052e-03 4.360378e-03 16 84178781 84178847 67 - 2.166 2.304 0.460
ENSG00000103168 E008 284.515831 0.0026416018 8.798585e-06 5.922842e-05 16 84178848 84179121 274 - 2.335 2.493 0.524
ENSG00000103168 E009 136.890468 0.0002697569 1.024774e-13 2.910214e-12 16 84179122 84179285 164 - 1.941 2.199 0.864
ENSG00000103168 E010 61.514005 0.0004197487 1.201253e-06 9.809216e-06 16 84179286 84179302 17 - 1.602 1.851 0.842
ENSG00000103168 E011 100.800141 0.0003767215 1.942068e-05 1.208629e-04 16 84179303 84179364 62 - 1.874 2.046 0.578
ENSG00000103168 E012 127.330062 0.0008358314 4.919683e-05 2.776759e-04 16 84179365 84179420 56 - 1.988 2.143 0.518
ENSG00000103168 E013 127.358285 0.0003058216 1.069345e-03 4.198896e-03 16 84179421 84179488 68 - 2.013 2.132 0.398
ENSG00000103168 E014 307.192068 0.0010141139 7.362042e-06 5.041996e-05 16 84179489 84179851 363 - 2.386 2.513 0.424
ENSG00000103168 E015 101.742219 0.0110956604 4.691154e-03 1.507208e-02 16 84179946 84180080 135 - 1.853 2.057 0.686
ENSG00000103168 E016 31.290346 0.0006616033 3.434847e-02 8.042933e-02 16 84180081 84180083 3 - 1.386 1.535 0.514
ENSG00000103168 E017 136.989196 0.0002333475 1.857299e-02 4.839087e-02 16 84180170 84180344 175 - 2.065 2.149 0.284
ENSG00000103168 E018 92.493379 0.0002823489 3.303207e-14 1.006567e-12 16 84180345 84180867 523 - 2.100 1.831 -0.903
ENSG00000103168 E019 40.875454 0.0027222382 2.091005e-10 3.491152e-09 16 84180868 84180995 128 - 1.796 1.428 -1.253
ENSG00000103168 E020 29.700913 0.0006812418 3.099477e-10 5.031590e-09 16 84180996 84181042 47 - 1.671 1.279 -1.348
ENSG00000103168 E021 179.886445 0.0007685099 1.532964e-01 2.661578e-01 16 84181043 84181186 144 - 2.260 2.230 -0.103
ENSG00000103168 E022 3.171069 0.0052047253 1.132555e-02 3.194318e-02 16 84181290 84181327 38 - 0.803 0.425 -1.686
ENSG00000103168 E023 113.803202 0.0017007127 1.043674e-02 2.983250e-02 16 84181328 84181369 42 - 2.096 2.010 -0.291
ENSG00000103168 E024 121.210943 0.0011700366 1.215566e-01 2.221524e-01 16 84181370 84181429 60 - 2.098 2.053 -0.148
ENSG00000103168 E025 109.514866 0.0002655705 8.244888e-03 2.440501e-02 16 84181430 84181463 34 - 2.073 1.993 -0.270
ENSG00000103168 E026 62.642482 0.0019177006 3.953165e-15 1.381253e-13 16 84181464 84181495 32 - 1.978 1.607 -1.253
ENSG00000103168 E027 74.625399 0.0003559652 1.013129e-15 3.821106e-14 16 84181496 84181591 96 - 2.032 1.714 -1.072
ENSG00000103168 E028 123.990491 0.0012277597 1.018083e-01 1.932554e-01 16 84181592 84181663 72 - 2.109 2.062 -0.159
ENSG00000103168 E029 148.863067 0.0003239269 3.216386e-01 4.648926e-01 16 84181746 84181863 118 - 2.171 2.151 -0.066
ENSG00000103168 E030 61.117760 0.0004072535 1.937454e-10 3.253367e-09 16 84181864 84181941 78 - 1.928 1.651 -0.935
ENSG00000103168 E031 112.514381 0.0003015235 3.725005e-01 5.169565e-01 16 84181942 84182031 90 - 2.049 2.028 -0.069
ENSG00000103168 E032 65.559711 0.0017533333 2.799867e-01 4.197851e-01 16 84182032 84182058 27 - 1.829 1.787 -0.141
ENSG00000103168 E033 33.308504 0.0008695447 7.863519e-12 1.664864e-10 16 84182059 84182146 88 - 1.724 1.316 -1.401
ENSG00000103168 E034 30.524686 0.0129231141 1.612221e-04 7.973433e-04 16 84182147 84182201 55 - 1.634 1.340 -1.011
ENSG00000103168 E035 76.113760 0.0003764636 7.249982e-01 8.183509e-01 16 84182202 84182266 65 - 1.867 1.862 -0.015
ENSG00000103168 E036 91.862102 0.0007137165 9.779680e-01 9.903468e-01 16 84182267 84182335 69 - 1.939 1.951 0.038
ENSG00000103168 E037 114.136898 0.0015642369 8.856639e-01 9.308664e-01 16 84182336 84182440 105 - 2.035 2.041 0.022
ENSG00000103168 E038 7.401104 0.0023031729 9.295141e-03 2.702149e-02 16 84183072 84183075 4 - 1.068 0.777 -1.101
ENSG00000103168 E039 79.082400 0.0003980178 5.510772e-01 6.805909e-01 16 84183076 84183119 44 - 1.858 1.893 0.118
ENSG00000103168 E040 70.672368 0.0030124445 2.814527e-01 4.213586e-01 16 84183120 84183137 18 - 1.858 1.816 -0.140
ENSG00000103168 E041 67.731455 0.0058024615 3.240989e-01 4.674679e-01 16 84183138 84183149 12 - 1.839 1.799 -0.137
ENSG00000103168 E042 6.087141 0.0027900970 1.667127e-04 8.210470e-04 16 84183150 84183243 94 - 1.068 0.607 -1.812
ENSG00000103168 E043 87.754235 0.0054425441 1.614571e-01 2.770036e-01 16 84183244 84183266 23 - 1.960 1.904 -0.188
ENSG00000103168 E044 83.399689 0.0008282471 1.213335e-02 3.385163e-02 16 84183267 84183272 6 - 1.958 1.866 -0.309
ENSG00000103168 E045 121.172749 0.0003069743 1.648338e-02 4.380561e-02 16 84183273 84183328 56 - 2.108 2.039 -0.231
ENSG00000103168 E046 76.056013 0.0006782221 7.156416e-02 1.459377e-01 16 84183329 84183333 5 - 1.908 1.842 -0.221
ENSG00000103168 E047 2.165090 0.1448891433 4.345647e-01 5.769039e-01 16 84183334 84183409 76 - 0.565 0.429 -0.664
ENSG00000103168 E048 146.165212 0.0010440692 7.972953e-03 2.370936e-02 16 84183410 84183507 98 - 2.195 2.119 -0.255
ENSG00000103168 E049 4.792075 0.0033659976 1.441753e-01 2.536878e-01 16 84183508 84183531 24 - 0.852 0.663 -0.763
ENSG00000103168 E050 121.275372 0.0028602578 3.244339e-01 4.677873e-01 16 84183697 84183778 82 - 2.087 2.059 -0.095
ENSG00000103168 E051 100.035408 0.0047812811 5.729319e-01 6.989564e-01 16 84184851 84184899 49 - 1.995 1.980 -0.049
ENSG00000103168 E052 118.309865 0.0071889376 2.460064e-01 3.812658e-01 16 84184900 84184989 90 - 2.086 2.040 -0.153
ENSG00000103168 E053 95.224727 0.0082791804 8.695588e-03 2.552611e-02 16 84184990 84185060 71 - 2.044 1.908 -0.458
ENSG00000103168 E054 8.813216 0.0019784456 8.409293e-06 5.683203e-05 16 84185158 84185479 322 - 1.212 0.735 -1.786
ENSG00000103168 E055 3.821563 0.0107713200 5.357497e-03 1.690307e-02 16 84185480 84185583 104 - 0.875 0.469 -1.742
ENSG00000103168 E056 114.760633 0.0087776006 1.373412e-01 2.443684e-01 16 84186901 84187070 170 - 2.089 2.018 -0.241