ENSG00000103091

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262144 ENSG00000103091 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR59 protein_coding protein_coding 33.75716 35.24985 28.35292 1.349259 0.3573148 -0.3140202 4.835910 6.428726 3.083599 0.2313430 0.04142344 -1.05748896 0.14146250 0.18286667 0.10873333 -0.07413333 6.225119e-05 1.306625e-05 FALSE  
ENST00000536050 ENSG00000103091 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR59 protein_coding protein_coding 33.75716 35.24985 28.35292 1.349259 0.3573148 -0.3140202 2.028269 2.157178 2.291397 0.2460261 0.07740838 0.08669208 0.06137083 0.06083333 0.08080000 0.01996667 2.349580e-01 1.306625e-05 FALSE  
ENST00000569549 ENSG00000103091 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR59 protein_coding retained_intron 33.75716 35.24985 28.35292 1.349259 0.3573148 -0.3140202 2.408231 1.873339 2.005987 0.4156264 0.20763735 0.09819356 0.07221250 0.05246667 0.07063333 0.01816667 5.713661e-01 1.306625e-05 FALSE  
ENST00000570070 ENSG00000103091 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR59 protein_coding retained_intron 33.75716 35.24985 28.35292 1.349259 0.3573148 -0.3140202 3.975259 2.712816 3.832623 0.3804253 0.38605849 0.49699224 0.11777917 0.07710000 0.13516667 0.05806667 6.446170e-02 1.306625e-05 FALSE  
MSTRG.13035.1 ENSG00000103091 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR59 protein_coding   33.75716 35.24985 28.35292 1.349259 0.3573148 -0.3140202 8.472724 9.018236 8.486393 1.2695786 0.62404085 -0.08759354 0.25288750 0.25470000 0.29903333 0.04433333 6.239531e-01 1.306625e-05 FALSE  
MSTRG.13035.3 ENSG00000103091 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR59 protein_coding   33.75716 35.24985 28.35292 1.349259 0.3573148 -0.3140202 6.484612 8.233490 4.072590 0.8346845 0.63459853 -1.01377058 0.18863333 0.23586667 0.14420000 -0.09166667 2.016189e-01 1.306625e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103091 E001 0.0000000       16 74844980 74845015 36 -      
ENSG00000103091 E002 351.8216115 0.0009698456 7.987163e-11 1.433173e-09 16 74871362 74874078 2717 - 2.403 2.571 0.559
ENSG00000103091 E003 211.7008748 0.0029885578 2.085666e-04 1.000666e-03 16 74874079 74874259 181 - 2.200 2.344 0.479
ENSG00000103091 E004 212.4170799 0.0043405496 1.228103e-01 2.239680e-01 16 74874260 74874394 135 - 2.255 2.323 0.228
ENSG00000103091 E005 120.2323088 0.0026171376 3.443483e-01 4.884341e-01 16 74874395 74874425 31 - 2.025 2.070 0.150
ENSG00000103091 E006 113.9862635 0.0023180776 8.940256e-01 9.362371e-01 16 74874426 74874444 19 - 2.027 2.038 0.036
ENSG00000103091 E007 226.3754129 0.0005191593 3.108296e-02 7.407012e-02 16 74885653 74885795 143 - 2.287 2.349 0.208
ENSG00000103091 E008 0.3289534 0.0289909307 6.968508e-01   16 74885796 74886235 440 - 0.153 0.097 -0.759
ENSG00000103091 E009 216.3877378 0.0001912408 1.127023e-01 2.094869e-01 16 74886270 74886396 127 - 2.279 2.324 0.151
ENSG00000103091 E010 0.6224193 0.0180651136 5.971656e-01 7.189828e-01 16 74886397 74886469 73 - 0.266 0.176 -0.760
ENSG00000103091 E011 167.8715210 0.0061339431 9.593893e-01 9.785249e-01 16 74887683 74887755 73 - 2.196 2.201 0.019
ENSG00000103091 E012 136.9695138 0.0010200778 9.474890e-01 9.709776e-01 16 74888169 74888210 42 - 2.107 2.114 0.023
ENSG00000103091 E013 117.4494576 0.0003001957 6.995505e-01 7.992313e-01 16 74888211 74888243 33 - 2.051 2.042 -0.030
ENSG00000103091 E014 141.2421941 0.0003081601 4.581858e-01 5.985101e-01 16 74888244 74888319 76 - 2.104 2.132 0.094
ENSG00000103091 E015 0.7425998 0.0622507845 3.112322e-01 4.536833e-01 16 74889660 74889702 43 - 0.356 0.175 -1.355
ENSG00000103091 E016 78.0245844 0.0004236137 3.670513e-01 5.114196e-01 16 74889703 74889722 20 - 1.840 1.883 0.144
ENSG00000103091 E017 132.0144466 0.0007383717 4.893119e-02 1.072579e-01 16 74889723 74889815 93 - 2.047 2.120 0.243
ENSG00000103091 E018 140.0528543 0.0002742043 1.444117e-01 2.540310e-01 16 74892484 74892565 82 - 2.088 2.139 0.171
ENSG00000103091 E019 104.3916652 0.0003118693 3.495669e-01 4.937845e-01 16 74893679 74893706 28 - 1.970 2.009 0.130
ENSG00000103091 E020 152.5194754 0.0002345501 6.939302e-01 7.948725e-01 16 74893707 74893812 106 - 2.165 2.158 -0.024
ENSG00000103091 E021 0.3332198 0.0300482089 6.968097e-01   16 74893813 74893940 128 - 0.153 0.097 -0.759
ENSG00000103091 E022 0.3332198 0.0300482089 6.968097e-01   16 74899698 74899754 57 - 0.153 0.097 -0.759
ENSG00000103091 E023 168.3192618 0.0002967590 2.971507e-02 7.139599e-02 16 74903947 74904100 154 - 2.239 2.181 -0.194
ENSG00000103091 E024 0.6299079 0.0229762111 1.274948e-01 2.306618e-01 16 74904101 74904346 246 - 0.356 0.097 -2.344
ENSG00000103091 E025 3.4213631 0.0045255584 6.624264e-03 2.025023e-02 16 74908733 74908907 175 - 0.266 0.740 2.410
ENSG00000103091 E026 122.8170904 0.0003866257 1.581256e-02 4.231670e-02 16 74908908 74908977 70 - 2.114 2.038 -0.257
ENSG00000103091 E027 96.7941639 0.0036797123 2.436180e-03 8.570219e-03 16 74909501 74909524 24 - 2.049 1.911 -0.462
ENSG00000103091 E028 165.3751635 0.0014102447 3.689164e-03 1.226465e-02 16 74909525 74909657 133 - 2.251 2.159 -0.309
ENSG00000103091 E029 22.4710455 0.0183115903 2.068477e-03 7.436788e-03 16 74909658 74909735 78 - 1.510 1.217 -1.018
ENSG00000103091 E030 15.6354381 0.0239463765 2.060230e-04 9.898417e-04 16 74909747 74909821 75 - 1.415 1.006 -1.453
ENSG00000103091 E031 115.8534140 0.0012147746 9.401478e-02 1.814024e-01 16 74909822 74909917 96 - 2.076 2.017 -0.198
ENSG00000103091 E032 19.0812784 0.0019344276 1.793684e-09 2.535345e-08 16 74912005 74912117 113 - 1.532 1.061 -1.653
ENSG00000103091 E033 30.5677007 0.0059695885 2.908912e-01 4.317019e-01 16 74912118 74912197 80 - 1.526 1.456 -0.241
ENSG00000103091 E034 220.5658738 0.0001891467 1.624163e-01 2.782863e-01 16 74912198 74912362 165 - 2.292 2.332 0.133
ENSG00000103091 E035 1.8799422 0.1395441970 9.030479e-01 9.423283e-01 16 74915460 74915679 220 - 0.430 0.469 0.203
ENSG00000103091 E036 1.7013583 0.3020049270 8.465383e-01 9.046415e-01 16 74915680 74915717 38 - 0.356 0.461 0.577
ENSG00000103091 E037 0.0000000       16 74915718 74915869 152 -      
ENSG00000103091 E038 229.2612325 0.0054761659 1.793879e-01 3.003545e-01 16 74915870 74915994 125 - 2.294 2.356 0.206
ENSG00000103091 E039 7.0858537 0.0183306118 7.952532e-03 2.365754e-02 16 74915995 74916126 132 - 1.079 0.741 -1.289
ENSG00000103091 E040 247.8414718 0.0014879331 4.966367e-01 6.332752e-01 16 74916127 74916259 133 - 2.354 2.378 0.082
ENSG00000103091 E041 207.4419965 0.0002167126 9.187313e-01 9.526505e-01 16 74917929 74918008 80 - 2.288 2.295 0.024
ENSG00000103091 E042 260.3987847 0.0001683713 7.286406e-01 8.210605e-01 16 74921947 74922103 157 - 2.383 2.395 0.042
ENSG00000103091 E043 115.5335574 0.0002604503 3.556951e-01 5.000532e-01 16 74923926 74923949 24 - 2.015 2.051 0.123
ENSG00000103091 E044 152.6322149 0.0002627881 6.635081e-01 7.715420e-01 16 74923950 74924003 54 - 2.146 2.163 0.059
ENSG00000103091 E045 0.1472490 0.0430318738 2.926684e-01   16 74930768 74930792 25 - 0.153 0.000 -11.352
ENSG00000103091 E046 201.5054685 0.0002723375 6.045081e-01 7.250379e-01 16 74938150 74938250 101 - 2.286 2.277 -0.031
ENSG00000103091 E047 111.6520818 0.0003326004 4.898397e-01 6.272218e-01 16 74938251 74938266 16 - 2.037 2.017 -0.067
ENSG00000103091 E048 93.5463554 0.0003414493 9.713102e-01 9.860869e-01 16 74942738 74942739 2 - 1.946 1.948 0.010
ENSG00000103091 E049 179.2923418 0.0006535132 3.332074e-01 4.769021e-01 16 74942740 74942826 87 - 2.246 2.222 -0.081
ENSG00000103091 E050 137.0241583 0.0002419775 8.445785e-03 2.489968e-02 16 74948519 74948556 38 - 2.165 2.087 -0.260
ENSG00000103091 E051 177.7792673 0.0002110445 5.605337e-04 2.386700e-03 16 74949718 74949798 81 - 2.284 2.194 -0.301
ENSG00000103091 E052 1.3683431 0.0097199829 1.326578e-03 5.064002e-03 16 74949852 74949947 96 - 0.642 0.097 -3.759
ENSG00000103091 E053 179.8766217 0.0001904302 2.925862e-03 1.004678e-02 16 74951458 74951543 86 - 2.280 2.204 -0.256
ENSG00000103091 E054 89.9540123 0.0003306465 2.921440e-01 4.330914e-01 16 74956475 74956483 9 - 1.956 1.919 -0.123
ENSG00000103091 E055 167.5348640 0.0002544666 1.516699e-02 4.086500e-02 16 74956484 74956610 127 - 2.242 2.177 -0.217
ENSG00000103091 E056 1.3253775 0.0099214129 9.719168e-01 9.864390e-01 16 74959350 74959592 243 - 0.356 0.352 -0.023
ENSG00000103091 E057 2.3509332 0.0068311102 9.276110e-01 9.584648e-01 16 74960620 74960783 164 - 0.494 0.512 0.089
ENSG00000103091 E058 2.8818643 0.1249099514 6.481782e-01 7.597456e-01 16 74962820 74963247 428 - 0.495 0.582 0.411
ENSG00000103091 E059 94.8609377 0.0003928233 2.714177e-02 6.628842e-02 16 74965773 74965822 50 - 2.004 1.925 -0.266
ENSG00000103091 E060 0.1482932 0.0414205510 7.877421e-01   16 74979012 74979116 105 - 0.000 0.097 9.559
ENSG00000103091 E061 1.9208300 0.0074234326 1.380761e-01 2.454018e-01 16 74983716 74983808 93 - 0.598 0.352 -1.245
ENSG00000103091 E062 1.5575205 0.1926270118 3.809307e-01 5.252192e-01 16 74984603 74984963 361 - 0.494 0.307 -1.048
ENSG00000103091 E063 73.0765430 0.0004016263 1.329929e-02 3.661707e-02 16 74984964 74985123 160 - 1.909 1.808 -0.339
ENSG00000103091 E064 0.0000000       16 74996972 74997173 202 -      
ENSG00000103091 E065 0.0000000       16 75000023 75000173 151 -