ENSG00000103064

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000219343 ENSG00000103064 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A6 protein_coding protein_coding 28.9733 20.8004 32.30878 0.4782437 0.9319736 0.6350678 15.882553 13.4807592 15.362555 1.4257125 0.4642180 0.1883855 0.55985417 0.64693333 0.47653333 -0.17040000 1.228493e-01 1.005044e-31 FALSE TRUE
ENST00000566454 ENSG00000103064 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A6 protein_coding protein_coding 28.9733 20.8004 32.30878 0.4782437 0.9319736 0.6350678 1.699205 1.1435772 2.252636 0.5752855 0.5793698 0.9718901 0.06000000 0.05616667 0.06983333 0.01366667 8.298397e-01 1.005044e-31 FALSE TRUE
ENST00000567325 ENSG00000103064 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A6 protein_coding retained_intron 28.9733 20.8004 32.30878 0.4782437 0.9319736 0.6350678 1.726126 0.0000000 4.075387 0.0000000 0.2093576 8.6743291 0.05298750 0.00000000 0.12656667 0.12656667 1.005044e-31 1.005044e-31 FALSE TRUE
MSTRG.12873.1 ENSG00000103064 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A6 protein_coding   28.9733 20.8004 32.30878 0.4782437 0.9319736 0.6350678 1.624381 2.6102228 1.058499 0.4969006 0.5305421 -1.2941033 0.05975000 0.12483333 0.03263333 -0.09220000 3.831926e-01 1.005044e-31 TRUE TRUE
MSTRG.12873.2 ENSG00000103064 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A6 protein_coding   28.9733 20.8004 32.30878 0.4782437 0.9319736 0.6350678 2.055702 0.8034506 2.540445 0.1501098 0.1323789 1.6486222 0.06714583 0.03843333 0.07853333 0.04010000 7.333146e-03 1.005044e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103064 E001 1.2210941 0.0108647759 4.050604e-02 9.194853e-02 16 68264503 68264504 2 + 0.483 0.135 -2.488
ENSG00000103064 E002 1.5198585 0.0087143486 1.280838e-02 3.546378e-02 16 68264505 68264512 8 + 0.559 0.135 -2.850
ENSG00000103064 E003 3.0269418 0.0063902581 1.331271e-01 2.384842e-01 16 68264513 68264515 3 + 0.706 0.502 -0.905
ENSG00000103064 E004 3.7664212 0.0047363020 5.894792e-02 1.248352e-01 16 68264516 68264522 7 + 0.795 0.549 -1.045
ENSG00000103064 E005 4.2362809 0.0041100215 5.299066e-02 1.144689e-01 16 68264523 68264525 3 + 0.834 0.592 -1.004
ENSG00000103064 E006 15.5328062 0.0221844919 9.836897e-03 2.836355e-02 16 68264526 68264547 22 + 1.330 1.074 -0.908
ENSG00000103064 E007 15.7176310 0.0229049794 2.116104e-02 5.393738e-02 16 68264548 68264549 2 + 1.324 1.099 -0.795
ENSG00000103064 E008 21.4485329 0.0138372108 3.406443e-02 7.988665e-02 16 68264550 68264559 10 + 1.425 1.265 -0.556
ENSG00000103064 E009 46.8096640 0.0076453878 3.361153e-04 1.524866e-03 16 68264560 68264568 9 + 1.766 1.561 -0.695
ENSG00000103064 E010 59.7342767 0.0174999333 1.784377e-02 4.680118e-02 16 68264569 68264576 8 + 1.850 1.698 -0.514
ENSG00000103064 E011 0.1472490 0.0427949863 5.532087e-01   16 68264577 68264581 5 + 0.111 0.000 -11.981
ENSG00000103064 E012 3.8415212 0.0605522385 3.100791e-01 4.524462e-01 16 68264582 68264741 160 + 0.753 0.593 -0.676
ENSG00000103064 E013 0.9179615 0.0142616857 8.764155e-01 9.246833e-01 16 68265516 68265773 258 + 0.273 0.320 0.318
ENSG00000103064 E014 0.5212538 0.0214344623 4.934647e-01 6.304994e-01 16 68266591 68266592 2 + 0.111 0.237 1.320
ENSG00000103064 E015 53.9175966 0.0160727194 3.967906e-02 9.042884e-02 16 68266593 68266594 2 + 1.795 1.670 -0.421
ENSG00000103064 E016 55.6234128 0.0126389953 1.684831e-02 4.459548e-02 16 68266595 68266601 7 + 1.813 1.677 -0.461
ENSG00000103064 E017 121.2772228 0.0128074332 2.515124e-02 6.218859e-02 16 68266602 68266721 120 + 2.134 2.029 -0.351
ENSG00000103064 E018 0.4783925 0.0222308269 6.471976e-01 7.589235e-01 16 68272979 68273044 66 + 0.199 0.135 -0.680
ENSG00000103064 E019 7.7407272 0.0114864087 2.941031e-01 4.351866e-01 16 68273795 68273817 23 + 0.975 0.879 -0.362
ENSG00000103064 E020 18.7995725 0.0027723575 1.908702e-02 4.952786e-02 16 68273818 68273821 4 + 1.359 1.202 -0.549
ENSG00000103064 E021 38.9467736 0.0171489825 5.170863e-01 6.515414e-01 16 68273822 68273904 83 + 1.602 1.588 -0.049
ENSG00000103064 E022 205.6218431 0.0057252194 2.303843e-02 5.782715e-02 16 68274691 68274868 178 + 2.341 2.282 -0.200
ENSG00000103064 E023 75.5568268 0.0035137976 3.346942e-01 4.784301e-01 16 68274869 68274876 8 + 1.885 1.876 -0.031
ENSG00000103064 E024 154.6966589 0.0010776420 1.013964e-01 1.925894e-01 16 68274877 68275001 125 + 2.196 2.182 -0.047
ENSG00000103064 E025 147.8370651 0.0022744679 1.266937e-01 2.295434e-01 16 68275002 68275126 125 + 2.179 2.161 -0.060
ENSG00000103064 E026 130.1055407 0.0002510669 3.774645e-01 5.217959e-01 16 68275127 68275249 123 + 2.111 2.123 0.038
ENSG00000103064 E027 8.5514125 0.0401658710 3.862983e-01 5.304966e-01 16 68287323 68287435 113 + 1.026 0.948 -0.292
ENSG00000103064 E028 59.9482291 0.0004182255 8.547550e-02 1.681699e-01 16 68287746 68287759 14 + 1.804 1.764 -0.134
ENSG00000103064 E029 139.0347543 0.0018863674 2.121282e-01 3.410423e-01 16 68287760 68287871 112 + 2.147 2.140 -0.023
ENSG00000103064 E030 174.2460781 0.0002429200 3.320177e-02 7.819948e-02 16 68290396 68290540 145 + 2.251 2.233 -0.063
ENSG00000103064 E031 15.7645349 0.0011041021 1.626589e-03 6.045996e-03 16 68290962 68291208 247 + 1.324 1.089 -0.835
ENSG00000103064 E032 136.4322165 0.0002743544 8.653745e-01 9.172646e-01 16 68291209 68291285 77 + 2.113 2.157 0.147
ENSG00000103064 E033 104.9351439 0.0011006947 6.480120e-01 7.595932e-01 16 68291286 68291332 47 + 1.994 2.049 0.186
ENSG00000103064 E034 5.2582768 0.0072764019 1.326714e-01 2.378126e-01 16 68291333 68291557 225 + 0.870 0.699 -0.681
ENSG00000103064 E035 139.3466424 0.0003544196 9.925443e-01 9.994301e-01 16 68291558 68291661 104 + 2.125 2.164 0.130
ENSG00000103064 E036 0.7644715 0.1136871191 2.614579e-01 3.990975e-01 16 68294678 68294704 27 + 0.335 0.135 -1.675
ENSG00000103064 E037 161.1808182 0.0017841314 8.409422e-01 9.007406e-01 16 68294705 68294801 97 + 2.192 2.224 0.106
ENSG00000103064 E038 1.2606314 0.1268665331 4.798723e-01 6.182066e-01 16 68294802 68294907 106 + 0.273 0.445 1.031
ENSG00000103064 E039 219.5297704 0.0002093978 4.342635e-01 5.766448e-01 16 68296364 68296513 150 + 2.333 2.353 0.067
ENSG00000103064 E040 243.6583127 0.0001900363 4.849258e-01 6.228617e-01 16 68296627 68296810 184 + 2.378 2.401 0.077
ENSG00000103064 E041 225.6591071 0.0002445313 1.690299e-01 2.869270e-01 16 68297234 68297476 243 + 2.354 2.360 0.021
ENSG00000103064 E042 577.1612788 0.0015298089 1.802730e-01 3.015167e-01 16 68297477 68298490 1014 + 2.758 2.769 0.035
ENSG00000103064 E043 1809.8284977 0.0045096943 1.137262e-05 7.460728e-05 16 68298491 68301823 3333 + 3.183 3.324 0.467