ENSG00000103061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263997 ENSG00000103061 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A6OS protein_coding protein_coding 12.1681 12.65602 11.6684 0.2433684 0.4104111 -0.1171198 6.702701 6.246401 6.188476 0.2890766 0.36860390 -0.01341928 0.5484083 0.4931667 0.5336333 0.04046667 0.79777953 0.02324665 FALSE TRUE
ENST00000561590 ENSG00000103061 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A6OS protein_coding protein_coding 12.1681 12.65602 11.6684 0.2433684 0.4104111 -0.1171198 1.712384 1.828337 1.569506 0.1832563 0.06714861 -0.21892770 0.1413375 0.1440667 0.1348667 -0.00920000 0.87653582 0.02324665 FALSE FALSE
ENST00000568315 ENSG00000103061 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A6OS protein_coding nonsense_mediated_decay 12.1681 12.65602 11.6684 0.2433684 0.4104111 -0.1171198 1.485246 1.138129 1.868190 0.1086041 0.18472921 0.71005783 0.1220125 0.0903000 0.1598667 0.06956667 0.02324665 0.02324665   FALSE
ENST00000568538 ENSG00000103061 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A6OS protein_coding protein_coding 12.1681 12.65602 11.6684 0.2433684 0.4104111 -0.1171198 2.103793 3.443150 1.749550 0.2655200 0.46595264 -0.97270672 0.1747292 0.2725667 0.1477333 -0.12483333 0.12788737 0.02324665 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103061 E001 2.943174 0.0054058570 0.062116425 0.130201816 16 68284503 68284695 193 - 0.387 0.684 1.416
ENSG00000103061 E002 2.721833 0.0057272116 0.282957821 0.423031223 16 68298034 68298165 132 - 0.662 0.486 -0.800
ENSG00000103061 E003 549.413515 0.0024572768 0.053329222 0.115075585 16 68298166 68301405 3240 - 2.759 2.716 -0.144
ENSG00000103061 E004 17.040958 0.0024617311 0.677972611 0.782545824 16 68302000 68302380 381 - 1.244 1.271 0.095
ENSG00000103061 E005 117.995562 0.0004346016 0.786355411 0.863174362 16 68302381 68302501 121 - 2.083 2.065 -0.059
ENSG00000103061 E006 11.849531 0.0015392404 0.001079525 0.004233577 16 68302502 68302509 8 - 1.270 0.952 -1.146
ENSG00000103061 E007 10.034259 0.0024275781 0.124036181 0.225724727 16 68303690 68304025 336 - 0.932 1.087 0.571
ENSG00000103061 E008 156.147507 0.0003265154 0.188349220 0.311651220 16 68304026 68304232 207 - 2.174 2.200 0.088
ENSG00000103061 E009 139.845327 0.0018593993 0.041489494 0.093788752 16 68310335 68310613 279 - 2.106 2.163 0.190
ENSG00000103061 E010 1.202066 0.2100937407 0.058246987 0.123620278 16 68310614 68310734 121 - 0.544 0.113 -3.081
ENSG00000103061 E011 82.172041 0.0003420764 0.090783947 0.176372075 16 68310735 68310946 212 - 1.881 1.937 0.187