ENSG00000103051

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323786 ENSG00000103051 HEK293_OSMI2_2hA HEK293_TMG_2hB COG4 protein_coding protein_coding 34.32486 51.42449 24.48955 3.246173 0.3480564 -1.069981 29.009709 47.9208624 19.82851 2.97278006 0.76340603 -1.272651 0.82288750 0.9320667 0.8091333 -0.12293333 2.911790e-07 3.896915e-17 FALSE TRUE
ENST00000530314 ENSG00000103051 HEK293_OSMI2_2hA HEK293_TMG_2hB COG4 protein_coding retained_intron 34.32486 51.42449 24.48955 3.246173 0.3480564 -1.069981 2.294351 0.8715982 2.58080 0.09845025 0.01628643 1.555205 0.08097083 0.0173000 0.1054333 0.08813333 3.896915e-17 3.896915e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103051 E001 3.203153 0.0057394282 1.717337e-01 2.904705e-01 16 70480568 70480570 3 - 0.398 0.642 1.170
ENSG00000103051 E002 3.755640 0.0048079249 2.124840e-02 5.410910e-02 16 70480571 70480571 1 - 0.301 0.718 2.077
ENSG00000103051 E003 3.903933 0.0049183829 1.611371e-02 4.298771e-02 16 70480572 70480572 1 - 0.301 0.735 2.147
ENSG00000103051 E004 4.233931 0.0064827153 9.512867e-03 2.756898e-02 16 70480573 70480573 1 - 0.301 0.767 2.277
ENSG00000103051 E005 8.222516 0.0095906869 1.267098e-04 6.443375e-04 16 70480574 70480577 4 - 0.398 1.020 2.656
ENSG00000103051 E006 20.465279 0.0088289252 5.383964e-02 1.159722e-01 16 70480578 70480593 16 - 1.131 1.329 0.701
ENSG00000103051 E007 76.586147 0.0063444142 5.620995e-04 2.392453e-03 16 70480594 70480645 52 - 1.664 1.887 0.754
ENSG00000103051 E008 106.260786 0.0095659256 1.028746e-02 2.947375e-02 16 70480646 70480664 19 - 1.846 2.015 0.568
ENSG00000103051 E009 421.961053 0.0023870245 1.613179e-10 2.748137e-09 16 70480665 70480866 202 - 2.412 2.616 0.679
ENSG00000103051 E010 618.228477 0.0010884017 5.643582e-15 1.928499e-13 16 70480867 70481144 278 - 2.597 2.776 0.597
ENSG00000103051 E011 381.765034 0.0025669806 6.322438e-03 1.946323e-02 16 70481359 70481487 129 - 2.460 2.547 0.291
ENSG00000103051 E012 368.577110 0.0019121371 3.820040e-03 1.263655e-02 16 70481764 70481865 102 - 2.445 2.532 0.289
ENSG00000103051 E013 366.022770 0.0035802465 2.868128e-01 4.272591e-01 16 70482092 70482175 84 - 2.479 2.518 0.131
ENSG00000103051 E014 2.881767 0.0061389281 7.272589e-02 1.478834e-01 16 70482380 70482728 349 - 0.741 0.463 -1.245
ENSG00000103051 E015 384.987952 0.0013313686 8.936982e-01 9.360004e-01 16 70482729 70482821 93 - 2.526 2.533 0.024
ENSG00000103051 E016 394.136938 0.0001759183 4.055969e-01 5.492824e-01 16 70483853 70483969 117 - 2.551 2.539 -0.042
ENSG00000103051 E017 276.988327 0.0011341455 3.591583e-01 5.034961e-01 16 70490330 70490392 63 - 2.405 2.383 -0.076
ENSG00000103051 E018 362.202695 0.0004521605 8.274755e-01 8.915231e-01 16 70496266 70496379 114 - 2.506 2.504 -0.005
ENSG00000103051 E019 228.023206 0.0001752747 6.073765e-01 7.273678e-01 16 70496380 70496431 52 - 2.292 2.310 0.059
ENSG00000103051 E020 330.672749 0.0001536924 5.254883e-01 6.588483e-01 16 70497221 70497387 167 - 2.453 2.471 0.060
ENSG00000103051 E021 167.816257 0.0002530165 3.153240e-01 4.580827e-01 16 70497937 70497972 36 - 2.147 2.182 0.118
ENSG00000103051 E022 231.672328 0.0001879472 1.462335e-01 2.565617e-01 16 70497973 70498055 83 - 2.281 2.323 0.142
ENSG00000103051 E023 314.846094 0.0005020476 1.483212e-01 2.593906e-01 16 70500958 70501091 134 - 2.416 2.456 0.132
ENSG00000103051 E024 1.331605 0.1502666510 3.502901e-01 4.944852e-01 16 70501092 70501597 506 - 0.176 0.390 1.540
ENSG00000103051 E025 212.501993 0.0002106458 8.372514e-01 8.982448e-01 16 70508406 70508464 59 - 2.268 2.278 0.033
ENSG00000103051 E026 24.144474 0.0022058624 6.433670e-10 9.894784e-09 16 70508465 70508665 201 - 1.624 1.181 -1.535
ENSG00000103051 E027 16.287004 0.0130126610 8.377673e-09 1.047331e-07 16 70508666 70508824 159 - 1.513 0.948 -2.002
ENSG00000103051 E028 28.560480 0.0017394643 1.155179e-26 1.448347e-24 16 70508825 70509230 406 - 1.807 1.094 -2.465
ENSG00000103051 E029 301.822480 0.0008301604 1.976516e-04 9.538057e-04 16 70509231 70509388 158 - 2.492 2.401 -0.304
ENSG00000103051 E030 0.000000       16 70509872 70509915 44 -      
ENSG00000103051 E031 245.424418 0.0017469759 3.723934e-04 1.667374e-03 16 70509916 70510021 106 - 2.414 2.306 -0.360
ENSG00000103051 E032 161.255318 0.0028178660 1.818639e-02 4.753332e-02 16 70512239 70512266 28 - 2.219 2.129 -0.301
ENSG00000103051 E033 121.170132 0.0045789639 8.775442e-02 1.717262e-01 16 70512267 70512272 6 - 2.089 2.010 -0.262
ENSG00000103051 E034 163.224749 0.0044136122 3.268547e-02 7.717440e-02 16 70512273 70512318 46 - 2.224 2.135 -0.300
ENSG00000103051 E035 128.866264 0.0039634805 8.689115e-03 2.550869e-02 16 70512319 70512336 18 - 2.140 2.027 -0.381
ENSG00000103051 E036 145.150570 0.0002304418 4.478553e-02 9.981512e-02 16 70512337 70512373 37 - 2.154 2.094 -0.201
ENSG00000103051 E037 172.884896 0.0002366079 1.752468e-03 6.448225e-03 16 70512374 70512432 59 - 2.247 2.159 -0.294
ENSG00000103051 E038 142.821254 0.0026486961 7.773959e-02 1.558388e-01 16 70514335 70514365 31 - 2.150 2.082 -0.229
ENSG00000103051 E039 288.096483 0.0095314666 6.618032e-02 1.370117e-01 16 70514366 70514509 144 - 2.468 2.378 -0.300
ENSG00000103051 E040 3.539226 0.1800620224 3.001479e-03 1.026911e-02 16 70515868 70516040 173 - 1.003 0.311 -3.118
ENSG00000103051 E041 247.579568 0.0056082126 1.963879e-02 5.071303e-02 16 70517626 70517740 115 - 2.408 2.310 -0.328
ENSG00000103051 E042 135.537100 0.0010010829 6.825268e-03 2.076918e-02 16 70519649 70519676 28 - 2.145 2.053 -0.310
ENSG00000103051 E043 160.964560 0.0005353290 3.437824e-03 1.154680e-02 16 70519677 70519731 55 - 2.217 2.128 -0.296
ENSG00000103051 E044 3.758024 0.1134897349 7.903367e-02 1.579685e-01 16 70523087 70523372 286 - 0.846 0.523 -1.366
ENSG00000103051 E045 192.732125 0.0057782352 7.100036e-02 1.449987e-01 16 70523373 70523571 199 - 2.289 2.207 -0.271