ENSG00000103043

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261776 ENSG00000103043 HEK293_OSMI2_2hA HEK293_TMG_2hB VAC14 protein_coding protein_coding 42.48703 67.68697 27.87555 0.2933229 0.5557287 -1.279573 26.538247 42.382475 17.728743 2.5711174 0.9009861 -1.256904372 0.62353750 0.62643333 0.6359000 0.009466667 9.773984e-01 2.193889e-15 FALSE  
ENST00000566416 ENSG00000103043 HEK293_OSMI2_2hA HEK293_TMG_2hB VAC14 protein_coding protein_coding 42.48703 67.68697 27.87555 0.2933229 0.5557287 -1.279573 1.793625 3.985413 0.000000 0.7870910 0.0000000 -8.642200931 0.03286667 0.05880000 0.0000000 -0.058800000 2.193889e-15 2.193889e-15 FALSE  
ENST00000567648 ENSG00000103043 HEK293_OSMI2_2hA HEK293_TMG_2hB VAC14 protein_coding protein_coding 42.48703 67.68697 27.87555 0.2933229 0.5557287 -1.279573 1.003228 3.580748 0.000000 3.5807476 0.0000000 -8.488140426 0.01523750 0.05270000 0.0000000 -0.052700000 9.265474e-01 2.193889e-15    
ENST00000571759 ENSG00000103043 HEK293_OSMI2_2hA HEK293_TMG_2hB VAC14 protein_coding processed_transcript 42.48703 67.68697 27.87555 0.2933229 0.5557287 -1.279573 6.078379 9.809396 3.550841 0.7315288 0.1931900 -1.463416162 0.14054583 0.14496667 0.1272333 -0.017733333 6.551413e-01 2.193889e-15 FALSE  
MSTRG.12939.9 ENSG00000103043 HEK293_OSMI2_2hA HEK293_TMG_2hB VAC14 protein_coding   42.48703 67.68697 27.87555 0.2933229 0.5557287 -1.279573 4.904281 4.395727 4.412776 0.7438175 0.2241172 0.005571938 0.13265417 0.06503333 0.1583667 0.093333333 1.034310e-03 2.193889e-15 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103043 E001 1.0714635 0.3933482311 2.155378e-01 3.450568e-01 16 70687439 70687440 2 - 0.000 0.368 13.616
ENSG00000103043 E002 1.0714635 0.3933482311 2.155378e-01 3.450568e-01 16 70687441 70687441 1 - 0.000 0.368 13.572
ENSG00000103043 E003 774.6656467 0.0027283243 2.903028e-11 5.604874e-10 16 70687442 70688039 598 - 2.669 2.865 0.651
ENSG00000103043 E004 168.0893467 0.0002354268 7.948599e-09 9.983678e-08 16 70688040 70688042 3 - 2.005 2.203 0.662
ENSG00000103043 E005 252.5489742 0.0002495575 4.039212e-11 7.608796e-10 16 70688043 70688090 48 - 2.189 2.376 0.623
ENSG00000103043 E006 593.6485456 0.0007497772 3.313075e-04 1.505991e-03 16 70688091 70691049 2959 - 2.645 2.724 0.263
ENSG00000103043 E007 16.6863984 0.0389067958 2.614924e-01 3.991343e-01 16 70691786 70691787 2 - 1.271 1.141 -0.461
ENSG00000103043 E008 26.7629791 0.0303121416 1.563959e-01 2.703278e-01 16 70691788 70691861 74 - 1.478 1.336 -0.494
ENSG00000103043 E009 37.0189683 0.0010691579 2.890358e-02 6.981013e-02 16 70691862 70692049 188 - 1.607 1.472 -0.462
ENSG00000103043 E010 384.8687730 0.0010208160 1.269337e-06 1.031095e-05 16 70692821 70692971 151 - 2.418 2.549 0.436
ENSG00000103043 E011 351.1488307 0.0041273695 3.241842e-02 7.666520e-02 16 70695544 70695623 80 - 2.415 2.502 0.290
ENSG00000103043 E012 2.1306194 0.0089598641 6.994854e-01 7.991954e-01 16 70695624 70695856 233 - 0.488 0.421 -0.343
ENSG00000103043 E013 1.8821203 0.0096401004 1.154388e-01 2.134841e-01 16 70696890 70697138 249 - 0.614 0.347 -1.347
ENSG00000103043 E014 306.5182755 0.0013802959 9.319338e-02 1.801150e-01 16 70697139 70697173 35 - 2.381 2.435 0.178
ENSG00000103043 E015 349.0788095 0.0002172733 1.457937e-02 3.954327e-02 16 70697174 70697257 84 - 2.433 2.491 0.193
ENSG00000103043 E016 450.4336847 0.0001942690 3.009967e-01 4.427692e-01 16 70698637 70698811 175 - 2.570 2.594 0.078
ENSG00000103043 E017 14.3812810 0.0172895216 9.879404e-02 1.886394e-01 16 70699259 70700245 987 - 0.969 1.176 0.753
ENSG00000103043 E018 1.3534014 0.1983126910 8.777059e-02 1.717497e-01 16 70731275 70731307 33 - 0.000 0.416 13.842
ENSG00000103043 E019 1.7168102 0.3398876931 9.441353e-02 1.820013e-01 16 70731308 70731359 52 - 0.000 0.478 14.162
ENSG00000103043 E020 2.8679443 0.0054616256 1.359862e-01 2.424561e-01 16 70731360 70731494 135 - 0.309 0.587 1.463
ENSG00000103043 E021 370.6979291 0.0013942099 8.627196e-01 9.154641e-01 16 70731495 70731627 133 - 2.496 2.505 0.030
ENSG00000103043 E022 413.0995913 0.0013622383 3.163532e-02 7.514251e-02 16 70744423 70744579 157 - 2.588 2.537 -0.169
ENSG00000103043 E023 0.4448795 0.5465246005 6.173095e-01 7.351393e-01 16 70744580 70744638 59 - 0.000 0.197 12.362
ENSG00000103043 E024 0.0000000       16 70745026 70745082 57 -      
ENSG00000103043 E025 323.6379039 0.0002040308 5.942056e-04 2.512236e-03 16 70762540 70762605 66 - 2.496 2.422 -0.245
ENSG00000103043 E026 282.7676845 0.0001794101 6.205736e-04 2.608689e-03 16 70762881 70762924 44 - 2.441 2.363 -0.260
ENSG00000103043 E027 359.6360682 0.0014232897 3.307492e-02 7.795791e-02 16 70762925 70763025 101 - 2.531 2.477 -0.178
ENSG00000103043 E028 228.9970497 0.0025518524 9.430271e-01 9.682668e-01 16 70772109 70772169 61 - 2.291 2.299 0.024
ENSG00000103043 E029 131.4701510 0.0015251663 3.910646e-01 5.350091e-01 16 70772170 70772172 3 - 2.077 2.047 -0.099
ENSG00000103043 E030 140.7886571 0.0004001455 7.174973e-02 1.462611e-01 16 70780790 70780797 8 - 2.126 2.068 -0.195
ENSG00000103043 E031 387.3483042 0.0006789137 5.800185e-03 1.808770e-02 16 70780798 70780939 142 - 2.564 2.505 -0.199
ENSG00000103043 E032 321.6597207 0.0021019383 1.701734e-02 4.497230e-02 16 70781869 70782003 135 - 2.491 2.423 -0.227
ENSG00000103043 E033 280.5314166 0.0021203885 3.237121e-03 1.096483e-02 16 70783033 70783139 107 - 2.446 2.358 -0.295
ENSG00000103043 E034 276.1322086 0.0021286715 7.125424e-03 2.155032e-02 16 70783445 70783554 110 - 2.434 2.354 -0.269
ENSG00000103043 E035 280.7548847 0.0033021872 9.430799e-02 1.818455e-01 16 70784113 70784220 108 - 2.423 2.369 -0.182
ENSG00000103043 E036 0.2966881 0.0290785164 4.696780e-02   16 70784770 70784775 6 - 0.309 0.000 -14.830
ENSG00000103043 E037 235.3250347 0.0021687368 3.000129e-03 1.026530e-02 16 70784776 70784838 63 - 2.375 2.280 -0.316
ENSG00000103043 E038 276.1021088 0.0012971797 1.654565e-02 4.394089e-02 16 70785702 70785869 168 - 2.423 2.358 -0.218
ENSG00000103043 E039 0.2998086 0.0288084876 4.926983e-01   16 70785870 70786214 345 - 0.182 0.081 -1.348
ENSG00000103043 E040 231.6977708 0.0001725955 8.243592e-06 5.583168e-05 16 70786215 70786365 151 - 2.380 2.268 -0.371
ENSG00000103043 E041 0.4031496 0.0246237769 5.980284e-01 7.197060e-01 16 70786366 70786427 62 - 0.000 0.149 11.868
ENSG00000103043 E042 252.5544255 0.0062173932 6.682413e-06 4.624354e-05 16 70800797 70801161 365 - 2.472 2.281 -0.639