ENSG00000103042

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000219320 ENSG00000103042 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC38A7 protein_coding protein_coding 14.68713 15.68375 12.41412 0.7643045 0.4455636 -0.3370459 11.12397 13.1805419 8.6087128 0.3955171 0.1203397 -0.61395951 0.75542500 0.84220000 0.6946 -0.14760000 0.003404557 0.0001137871 FALSE TRUE
ENST00000569209 ENSG00000103042 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC38A7 protein_coding retained_intron 14.68713 15.68375 12.41412 0.7643045 0.4455636 -0.3370459 1.04424 0.8753214 0.9236025 0.1499290 0.1500549 0.07660712 0.07229167 0.05676667 0.0737 0.01693333 0.686318479 0.0001137871 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103042 E001 512.6555712 0.0103352354 3.394443e-07 3.106454e-06 16 58665109 58666371 1263 - 2.509 2.783 0.913
ENSG00000103042 E002 367.6499679 0.0014426425 9.070231e-01 9.449997e-01 16 58666372 58667277 906 - 2.520 2.571 0.171
ENSG00000103042 E003 108.5598216 0.0008341155 2.998802e-05 1.784839e-04 16 58667278 58667361 84 - 2.084 1.983 -0.340
ENSG00000103042 E004 75.1898102 0.0003483192 4.016337e-08 4.416293e-07 16 58667362 58667382 21 - 1.967 1.792 -0.588
ENSG00000103042 E005 106.4171082 0.0002899707 6.803386e-06 4.698972e-05 16 58667383 58667487 105 - 2.078 1.972 -0.357
ENSG00000103042 E006 64.7976573 0.0003790275 1.100955e-02 3.118470e-02 16 58670113 58670167 55 - 1.843 1.778 -0.218
ENSG00000103042 E007 76.3158167 0.0003563388 5.815932e-01 7.061125e-01 16 58671045 58671244 200 - 1.857 1.881 0.082
ENSG00000103042 E008 14.1002853 0.0032610402 7.787690e-02 1.560644e-01 16 58671572 58672029 458 - 1.226 1.108 -0.422
ENSG00000103042 E009 5.7006852 0.0041935535 1.388289e-01 2.464830e-01 16 58672030 58672095 66 - 0.891 0.740 -0.593
ENSG00000103042 E010 73.5852068 0.0003646297 6.554063e-01 7.652964e-01 16 58672096 58672243 148 - 1.814 1.879 0.222
ENSG00000103042 E011 1.8026215 0.0080454309 2.759972e-03 9.552029e-03 16 58675213 58675342 130 - 0.000 0.581 13.453
ENSG00000103042 E012 36.5336289 0.0006730777 9.277780e-01 9.585669e-01 16 58675940 58675943 4 - 1.529 1.581 0.176
ENSG00000103042 E013 72.4923974 0.0003713756 8.855393e-01 9.307846e-01 16 58675944 58676022 79 - 1.828 1.869 0.138
ENSG00000103042 E014 53.0935417 0.0018029852 3.872931e-01 5.314379e-01 16 58676023 58676054 32 - 1.721 1.724 0.007
ENSG00000103042 E015 9.2527177 0.0020077079 4.244438e-02 9.552507e-02 16 58676055 58676121 67 - 1.103 0.933 -0.625
ENSG00000103042 E016 9.7749881 0.0134056536 2.397358e-01 3.738135e-01 16 58676122 58676288 167 - 1.077 0.986 -0.331
ENSG00000103042 E017 53.6848590 0.0004578038 7.976052e-01 8.708707e-01 16 58676289 58676346 58 - 1.689 1.748 0.201
ENSG00000103042 E018 72.1340723 0.0003659647 4.583515e-01 5.986895e-01 16 58677326 58677424 99 - 1.840 1.856 0.053
ENSG00000103042 E019 6.1645930 0.0026741022 2.965620e-01 4.377959e-01 16 58677425 58677577 153 - 0.891 0.802 -0.347
ENSG00000103042 E020 73.7936498 0.0003813299 4.180804e-01 5.613711e-01 16 58678333 58678474 142 - 1.850 1.863 0.044
ENSG00000103042 E021 43.8699502 0.0049262747 8.923691e-01 9.352245e-01 16 58678696 58678742 47 - 1.600 1.656 0.188
ENSG00000103042 E022 68.2935956 0.0008933449 4.171290e-01 5.605164e-01 16 58678743 58678880 138 - 1.816 1.827 0.035
ENSG00000103042 E023 28.2582006 0.0008752174 7.196933e-01 8.144447e-01 16 58678881 58678894 14 - 1.438 1.460 0.076
ENSG00000103042 E024 0.8920389 0.0152026813 1.933829e-01 3.180275e-01 16 58679610 58679856 247 - 0.399 0.193 -1.428
ENSG00000103042 E025 28.5956101 0.0019727182 8.288443e-01 8.924751e-01 16 58679857 58679873 17 - 1.419 1.480 0.210
ENSG00000103042 E026 138.9086123 0.0003470995 4.788767e-03 1.534302e-02 16 58679874 58680241 368 - 2.154 2.115 -0.129
ENSG00000103042 E027 0.4449813 0.0214920125 3.580697e-01 5.024496e-01 16 58681388 58681515 128 - 0.244 0.107 -1.427
ENSG00000103042 E028 0.1451727 0.0431136387 3.336889e-01   16 58681516 58681708 193 - 0.139 0.000 -10.434
ENSG00000103042 E029 0.1451727 0.0431136387 3.336889e-01   16 58681709 58681871 163 - 0.139 0.000 -10.434
ENSG00000103042 E030 0.8010032 0.1204771042 4.128516e-01 5.564342e-01 16 58683666 58683954 289 - 0.328 0.194 -1.004
ENSG00000103042 E031 85.1964017 0.0012025209 5.265244e-02 1.138772e-01 16 58683955 58684083 129 - 1.941 1.909 -0.108
ENSG00000103042 E032 54.3308330 0.0022790739 2.545423e-01 3.912495e-01 16 58684084 58684135 52 - 1.737 1.724 -0.043
ENSG00000103042 E033 44.1705409 0.0068631700 3.410132e-01 4.849453e-01 16 58684136 58684178 43 - 1.651 1.635 -0.053
ENSG00000103042 E034 11.4889801 0.0161950617 3.223648e-01 4.656722e-01 16 58684179 58684716 538 - 1.116 1.049 -0.243
ENSG00000103042 E035 26.3242247 0.0007761998 2.831526e-01 4.232410e-01 16 58684717 58684770 54 - 1.438 1.410 -0.094