ENSG00000103035

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000219313 ENSG00000103035 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD7 protein_coding protein_coding 74.93982 59.74571 90.87001 4.197003 1.994125 0.6048866 20.29329 19.83468 23.39362 1.812257 1.558175 0.2379791 0.2750000 0.3312000 0.2571333 -0.07406667 0.02496763 0.02443598 FALSE  
ENST00000568615 ENSG00000103035 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD7 protein_coding protein_coding 74.93982 59.74571 90.87001 4.197003 1.994125 0.6048866 51.15390 38.60359 63.41527 2.473357 1.494548 0.7159489 0.6787833 0.6467667 0.6980000 0.05123333 0.14477435 0.02443598 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103035 E001 26.996123 0.0007019753 5.641635e-01 6.915112e-01 16 74296814 74296814 1 + 1.429 1.475 0.159
ENSG00000103035 E002 29.167341 0.0006892460 3.691660e-01 5.136035e-01 16 74296815 74296819 5 + 1.453 1.518 0.225
ENSG00000103035 E003 29.461938 0.0006606975 3.289432e-01 4.724193e-01 16 74296820 74296820 1 + 1.453 1.523 0.241
ENSG00000103035 E004 83.315630 0.0003384216 2.769730e-08 3.139575e-07 16 74296821 74296828 8 + 2.025 1.815 -0.706
ENSG00000103035 E005 593.571753 0.0011464565 1.686818e-01 2.864569e-01 16 74296829 74296988 160 + 2.789 2.764 -0.083
ENSG00000103035 E006 22.714779 0.0397298074 4.454657e-02 9.936436e-02 16 74297935 74298209 275 + 1.479 1.257 -0.771
ENSG00000103035 E007 9.121468 0.0018425537 9.791998e-02 1.873481e-01 16 74299576 74299745 170 + 1.088 0.919 -0.624
ENSG00000103035 E008 756.698408 0.0003976988 7.543109e-01 8.399906e-01 16 74300115 74300206 92 + 2.877 2.888 0.035
ENSG00000103035 E009 2.376497 0.0187432789 7.568168e-03 2.269049e-02 16 74300207 74300477 271 + 0.695 0.230 -2.502
ENSG00000103035 E010 756.680902 0.0001615076 5.728192e-01 6.988736e-01 16 74301052 74301144 93 + 2.884 2.884 0.001
ENSG00000103035 E011 1019.904726 0.0001119029 1.821310e-04 8.870650e-04 16 74301555 74301652 98 + 3.030 2.995 -0.115
ENSG00000103035 E012 982.563528 0.0006134182 3.916358e-03 1.290873e-02 16 74302212 74302292 81 + 3.014 2.975 -0.131
ENSG00000103035 E013 10.719913 0.0740196505 1.839615e-01 3.061882e-01 16 74303989 74304302 314 + 1.175 0.949 -0.826
ENSG00000103035 E014 1045.989391 0.0001047699 8.226160e-01 8.881669e-01 16 74304303 74304394 92 + 3.018 3.028 0.033
ENSG00000103035 E015 25.651276 0.0096264231 5.222948e-07 4.602623e-06 16 74304395 74304709 315 + 1.598 1.181 -1.447
ENSG00000103035 E016 1300.240945 0.0006757099 1.276779e-02 3.536803e-02 16 74305289 74305445 157 + 3.095 3.135 0.133
ENSG00000103035 E017 1892.583596 0.0005806552 3.900504e-05 2.254099e-04 16 74305446 74309554 4109 + 3.251 3.305 0.179
ENSG00000103035 E018 0.000000       16 74319896 74321860 1965 +