ENSG00000103034

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258187 ENSG00000103034 HEK293_OSMI2_2hA HEK293_TMG_2hB NDRG4 protein_coding protein_coding 4.306203 7.085608 2.689177 0.04485683 0.37306 -1.394407 0.2767538 0.3100328 0.3286896 0.1857973 0.2575762 0.08174398 0.07524583 0.04373333 0.13906667 0.09533333 8.209978e-01 1.528534e-09 FALSE TRUE
ENST00000565088 ENSG00000103034 HEK293_OSMI2_2hA HEK293_TMG_2hB NDRG4 protein_coding protein_coding 4.306203 7.085608 2.689177 0.04485683 0.37306 -1.394407 0.2360392 0.3812970 0.0000000 0.2103574 0.0000000 -5.29019198 0.04681250 0.05383333 0.00000000 -0.05383333 3.003862e-01 1.528534e-09 FALSE FALSE
ENST00000566192 ENSG00000103034 HEK293_OSMI2_2hA HEK293_TMG_2hB NDRG4 protein_coding protein_coding 4.306203 7.085608 2.689177 0.04485683 0.37306 -1.394407 2.0190493 3.6084285 1.3161533 0.4227278 0.3902670 -1.44811569 0.44125000 0.50956667 0.49900000 -0.01056667 1.000000e+00 1.528534e-09 FALSE TRUE
ENST00000566265 ENSG00000103034 HEK293_OSMI2_2hA HEK293_TMG_2hB NDRG4 protein_coding retained_intron 4.306203 7.085608 2.689177 0.04485683 0.37306 -1.394407 0.4525365 1.4742640 0.0000000 0.2610544 0.0000000 -7.21360396 0.07599583 0.20786667 0.00000000 -0.20786667 1.528534e-09 1.528534e-09   FALSE
ENST00000566585 ENSG00000103034 HEK293_OSMI2_2hA HEK293_TMG_2hB NDRG4 protein_coding retained_intron 4.306203 7.085608 2.689177 0.04485683 0.37306 -1.394407 0.1138670 0.0000000 0.2582181 0.0000000 0.2582181 4.74533495 0.04191667 0.00000000 0.07516667 0.07516667 6.428323e-01 1.528534e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103034 E001 0.0000000       16 58462846 58462910 65 +      
ENSG00000103034 E002 0.0000000       16 58463370 58463435 66 +      
ENSG00000103034 E003 0.0000000       16 58463631 58463664 34 +      
ENSG00000103034 E004 0.0000000       16 58463665 58463703 39 +      
ENSG00000103034 E005 0.0000000       16 58463704 58463709 6 +      
ENSG00000103034 E006 0.0000000       16 58463710 58463712 3 +      
ENSG00000103034 E007 0.0000000       16 58463713 58463715 3 +      
ENSG00000103034 E008 0.1482932 0.0417116818 1.0000000000   16 58463716 58463722 7 + 0.000 0.076 8.951
ENSG00000103034 E009 0.1482932 0.0417116818 1.0000000000   16 58463723 58463724 2 + 0.000 0.076 11.108
ENSG00000103034 E010 0.6255398 0.0185746438 1.0000000000 1.000000000 16 58463725 58463797 73 + 0.191 0.197 0.056
ENSG00000103034 E011 0.0000000       16 58464024 58464281 258 +      
ENSG00000103034 E012 0.0000000       16 58464282 58464300 19 +      
ENSG00000103034 E013 0.0000000       16 58464301 58464303 3 +      
ENSG00000103034 E014 0.0000000       16 58464304 58464305 2 +      
ENSG00000103034 E015 0.0000000       16 58464306 58464312 7 +      
ENSG00000103034 E016 0.0000000       16 58464313 58464317 5 +      
ENSG00000103034 E017 0.0000000       16 58464318 58464467 150 +      
ENSG00000103034 E018 0.0000000       16 58464774 58464821 48 +      
ENSG00000103034 E019 0.0000000       16 58464822 58465041 220 +      
ENSG00000103034 E020 0.0000000       16 58465042 58465071 30 +      
ENSG00000103034 E021 0.0000000       16 58465072 58465235 164 +      
ENSG00000103034 E022 0.0000000       16 58472187 58472296 110 +      
ENSG00000103034 E023 0.1472490 0.0449016861 0.1628961788   16 58475612 58475657 46 + 0.191 0.000 -13.875
ENSG00000103034 E024 1.5133003 0.4033266871 0.1115126484 0.207775057 16 58487756 58487850 95 + 0.687 0.193 -2.792
ENSG00000103034 E025 2.6934920 0.2289936873 0.1503959563 0.262215396 16 58494964 58495008 45 + 0.776 0.399 -1.722
ENSG00000103034 E026 0.0000000       16 58495456 58495553 98 +      
ENSG00000103034 E027 0.3332198 0.0288545839 0.4414903034   16 58499144 58500046 903 + 0.191 0.076 -1.526
ENSG00000103034 E028 0.0000000       16 58500047 58500089 43 +      
ENSG00000103034 E029 0.5149111 0.0203440943 0.7617241321 0.845530105 16 58500090 58500106 17 + 0.191 0.141 -0.525
ENSG00000103034 E030 2.3112916 0.0177406554 0.8176694950 0.884717572 16 58500107 58500142 36 + 0.424 0.466 0.215
ENSG00000103034 E031 2.3112916 0.0177406554 0.8176694950 0.884717572 16 58500143 58500144 2 + 0.424 0.466 0.215
ENSG00000103034 E032 2.3112916 0.0177406554 0.8176694950 0.884717572 16 58500145 58500145 1 + 0.424 0.466 0.215
ENSG00000103034 E033 19.9109969 0.0425818486 0.3064405234 0.448612862 16 58500146 58500269 124 + 1.342 1.209 -0.467
ENSG00000103034 E034 0.5169874 0.0204405732 0.7601148106 0.844306096 16 58500270 58500987 718 + 0.191 0.141 -0.525
ENSG00000103034 E035 5.9875122 0.0034150305 0.4806622051 0.618899586 16 58500988 58501077 90 + 0.687 0.791 0.423
ENSG00000103034 E036 0.6234634 0.0186537282 1.0000000000 1.000000000 16 58501078 58501395 318 + 0.191 0.197 0.056
ENSG00000103034 E037 0.6234634 0.0186537282 1.0000000000 1.000000000 16 58501468 58501502 35 + 0.191 0.197 0.056
ENSG00000103034 E038 1.0684447 0.0312950136 0.3398146437 0.483734698 16 58501503 58501612 110 + 0.424 0.246 -1.118
ENSG00000103034 E039 0.5869318 0.3429519728 0.3940102851 0.537913224 16 58501613 58501678 66 + 0.322 0.137 -1.568
ENSG00000103034 E040 0.1472490 0.0449016861 0.1628961788   16 58501945 58501947 3 + 0.191 0.000 -13.875
ENSG00000103034 E041 0.1472490 0.0449016861 0.1628961788   16 58501948 58501972 25 + 0.191 0.000 -13.875
ENSG00000103034 E042 0.1472490 0.0449016861 0.1628961788   16 58501973 58502147 175 + 0.191 0.000 -13.875
ENSG00000103034 E043 0.9296148 0.1687694212 0.7047890960 0.803264188 16 58503706 58503743 38 + 0.324 0.243 -0.562
ENSG00000103034 E044 1.0715652 0.0892164238 0.8452497090 0.903727261 16 58503744 58503797 54 + 0.323 0.288 -0.229
ENSG00000103034 E045 16.8755682 0.0016704487 0.0302475142 0.072451996 16 58503798 58503832 35 + 1.320 1.129 -0.673
ENSG00000103034 E046 25.7659598 0.0008072662 0.3792701003 0.523531686 16 58503833 58503903 71 + 1.403 1.337 -0.231
ENSG00000103034 E047 0.1482932 0.0417116818 1.0000000000   16 58503904 58503957 54 + 0.000 0.076 11.108
ENSG00000103034 E048 0.7373013 0.2036649202 0.4808739617 0.619086609 16 58503958 58504153 196 + 0.323 0.193 -0.982
ENSG00000103034 E049 24.0124264 0.0049176653 0.6669655676 0.774326669 16 58504154 58504188 35 + 1.353 1.316 -0.127
ENSG00000103034 E050 27.5198784 0.0157817047 0.6263243317 0.742277378 16 58504189 58504274 86 + 1.412 1.367 -0.157
ENSG00000103034 E051 0.2924217 0.0277301035 0.0379078323   16 58504275 58504277 3 + 0.323 0.000 -14.898
ENSG00000103034 E052 21.8124829 0.0355763820 0.5839920425 0.707994960 16 58504359 58504421 63 + 1.216 1.290 0.258
ENSG00000103034 E053 24.4225953 0.0118092619 0.6482659063 0.759819701 16 58504589 58504649 61 + 1.353 1.310 -0.151
ENSG00000103034 E054 0.1451727 0.0428095577 0.1633934976   16 58504650 58504733 84 + 0.191 0.000 -13.885
ENSG00000103034 E055 0.1451727 0.0428095577 0.1633934976   16 58505989 58506120 132 + 0.191 0.000 -13.885
ENSG00000103034 E056 0.8751994 0.1387604051 0.5478956253 0.677868005 16 58506121 58506381 261 + 0.323 0.199 -0.921
ENSG00000103034 E057 0.5483223 0.0205170045 0.7631909159 0.846601102 16 58506382 58506386 5 + 0.191 0.141 -0.523
ENSG00000103034 E058 25.9921351 0.0072672488 0.2215029155 0.352201783 16 58506387 58506473 87 + 1.422 1.320 -0.351
ENSG00000103034 E059 23.0809632 0.0010507975 0.3904278246 0.534393329 16 58506558 58506614 57 + 1.353 1.284 -0.241
ENSG00000103034 E060 15.2668775 0.0183217115 0.6643921464 0.772219498 16 58506912 58506914 3 + 1.171 1.119 -0.185
ENSG00000103034 E061 16.8857340 0.0245482873 0.5306175394 0.663204535 16 58506915 58506923 9 + 1.232 1.156 -0.268
ENSG00000103034 E062 25.3183266 0.0008150014 0.1155952447 0.213694954 16 58506924 58506979 56 + 1.431 1.313 -0.408
ENSG00000103034 E063 22.4731103 0.0009294404 0.0449052075 0.100026536 16 58506980 58507015 36 + 1.412 1.257 -0.542
ENSG00000103034 E064 0.0000000       16 58507016 58507197 182 +      
ENSG00000103034 E065 0.3666179 0.0294969513 0.4425352609 0.584144324 16 58507499 58507727 229 + 0.191 0.076 -1.523
ENSG00000103034 E066 0.3666179 0.0294969513 0.4425352609 0.584144324 16 58507728 58507807 80 + 0.191 0.076 -1.523
ENSG00000103034 E067 27.3547025 0.0007294347 0.0937892816 0.181042948 16 58507808 58507864 57 + 1.465 1.344 -0.417
ENSG00000103034 E068 0.4782907 0.0221675275 0.4099403486 0.553562223 16 58507865 58507947 83 + 0.000 0.197 12.643
ENSG00000103034 E069 23.6937143 0.0026198336 0.9019507805 0.941541371 16 58507948 58507999 52 + 1.320 1.310 -0.036
ENSG00000103034 E070 23.4504850 0.0008331814 0.9856715299 0.995071846 16 58508962 58509009 48 + 1.308 1.309 0.003
ENSG00000103034 E071 0.2214452 0.0394318959 1.0000000000   16 58509010 58509148 139 + 0.000 0.076 11.119
ENSG00000103034 E072 0.2214452 0.0394318959 1.0000000000   16 58509149 58509153 5 + 0.000 0.076 11.119
ENSG00000103034 E073 20.9480232 0.0009041152 0.6413551855 0.754408786 16 58509154 58509189 36 + 1.231 1.271 0.140
ENSG00000103034 E074 21.5650567 0.0008956473 0.6067855457 0.726860414 16 58509301 58509352 52 + 1.245 1.288 0.152
ENSG00000103034 E075 0.2998086 0.0290577998 0.4403086065   16 58509353 58509389 37 + 0.191 0.076 -1.529
ENSG00000103034 E076 0.1482932 0.0417116818 1.0000000000   16 58510645 58510683 39 + 0.000 0.076 11.108
ENSG00000103034 E077 1.9467500 0.0076583472 0.5518874732 0.681294033 16 58510711 58511421 711 + 0.323 0.436 0.645
ENSG00000103034 E078 22.6064039 0.0008651336 0.3298243891 0.473372635 16 58511422 58511507 86 + 1.231 1.313 0.289
ENSG00000103034 E079 80.8592536 0.0003375919 0.0015090439 0.005665438 16 58511508 58512100 593 + 1.714 1.861 0.494
ENSG00000103034 E080 175.8158831 0.0028187437 0.0003819576 0.001705012 16 58512101 58513628 1528 + 2.068 2.194 0.421