ENSG00000102984

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313565 ENSG00000102984 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF821 protein_coding protein_coding 7.128184 9.339812 5.33862 0.2012735 0.1151313 -0.8057707 0.37319077 0.5753968 0.2653619 0.02836280 0.06586397 -1.0880857 0.05128750 0.06170000 0.04923333 -0.01246667 7.705679e-01 1.585065e-05 FALSE TRUE
ENST00000562808 ENSG00000102984 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF821 protein_coding nonsense_mediated_decay 7.128184 9.339812 5.33862 0.2012735 0.1151313 -0.8057707 0.35742507 0.1978554 0.3851697 0.10378992 0.19347805 0.9268922 0.05668333 0.02153333 0.07076667 0.04923333 7.682663e-01 1.585065e-05 FALSE TRUE
ENST00000564943 ENSG00000102984 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF821 protein_coding processed_transcript 7.128184 9.339812 5.33862 0.2012735 0.1151313 -0.8057707 0.09508598 0.0000000 0.2799359 0.00000000 0.27993593 4.8576622 0.01350000 0.00000000 0.05240000 0.05240000 7.461706e-01 1.585065e-05 TRUE FALSE
ENST00000566987 ENSG00000102984 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF821 protein_coding nonsense_mediated_decay 7.128184 9.339812 5.33862 0.2012735 0.1151313 -0.8057707 1.76454186 3.2029825 0.7837367 0.58296491 0.16250201 -2.0171808 0.23602500 0.34076667 0.14746667 -0.19330000 5.350158e-02 1.585065e-05 FALSE TRUE
ENST00000568666 ENSG00000102984 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF821 protein_coding protein_coding 7.128184 9.339812 5.33862 0.2012735 0.1151313 -0.8057707 0.48326349 0.5896042 0.6459573 0.29487615 0.19983129 0.1295915 0.07166667 0.06180000 0.12143333 0.05963333 6.583635e-01 1.585065e-05 FALSE TRUE
ENST00000569186 ENSG00000102984 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF821 protein_coding retained_intron 7.128184 9.339812 5.33862 0.2012735 0.1151313 -0.8057707 0.29122108 0.0896245 0.6847832 0.04490839 0.14065705 2.8019905 0.04604167 0.00970000 0.12913333 0.11943333 1.585065e-05 1.585065e-05 TRUE FALSE
ENST00000611294 ENSG00000102984 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF821 protein_coding protein_coding 7.128184 9.339812 5.33862 0.2012735 0.1151313 -0.8057707 2.03185743 2.5456651 1.3145917 0.15205428 0.39383550 -0.9481511 0.28149583 0.27226667 0.24370000 -0.02856667 8.430110e-01 1.585065e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102984 E001 0.1515154 0.0421986854 0.2163705721   16 71859680 71859684 5 - 0.174 0.000 -10.831
ENSG00000102984 E002 12.5863633 0.0106805707 0.6255027515 0.741609892 16 71859685 71859775 91 - 1.056 1.104 0.176
ENSG00000102984 E003 17.5923034 0.0011945858 0.6484796989 0.759971411 16 71859776 71859806 31 - 1.199 1.232 0.117
ENSG00000102984 E004 35.9968681 0.0077421663 0.2093796540 0.337798676 16 71859807 71859986 180 - 1.450 1.538 0.303
ENSG00000102984 E005 27.0834159 0.0008778307 0.0442035789 0.098767123 16 71859987 71860046 60 - 1.285 1.430 0.506
ENSG00000102984 E006 76.5462214 0.0004083280 0.0122807075 0.034205822 16 71860047 71860300 254 - 1.758 1.862 0.351
ENSG00000102984 E007 58.0582686 0.0016655880 0.4185650436 0.561820391 16 71860301 71860378 78 - 1.694 1.730 0.122
ENSG00000102984 E008 67.7856122 0.0051615918 0.0262844544 0.064518989 16 71860379 71860492 114 - 1.694 1.817 0.415
ENSG00000102984 E009 58.5578941 0.0004834174 0.0493520038 0.108011565 16 71860493 71860597 105 - 1.648 1.741 0.315
ENSG00000102984 E010 48.3726192 0.0006171819 0.5834424771 0.707564155 16 71860598 71860672 75 - 1.618 1.640 0.076
ENSG00000102984 E011 17.7713752 0.0011076428 0.5813010086 0.705848897 16 71861776 71861778 3 - 1.185 1.227 0.148
ENSG00000102984 E012 37.5432115 0.0006275852 0.6433076063 0.755902797 16 71861779 71861942 164 - 1.513 1.535 0.073
ENSG00000102984 E013 23.6921704 0.0009126238 0.7595932453 0.843904888 16 71864138 71864138 1 - 1.357 1.326 -0.108
ENSG00000102984 E014 47.9279156 0.0005417596 0.5230228231 0.656771227 16 71864139 71864235 97 - 1.613 1.640 0.094
ENSG00000102984 E015 32.7424453 0.0006854126 0.2594123810 0.396806625 16 71864236 71864242 7 - 1.426 1.495 0.235
ENSG00000102984 E016 1.9510085 0.0077232537 0.0006955964 0.002882991 16 71864754 71864898 145 - 0.774 0.216 -2.941
ENSG00000102984 E017 0.5869318 0.4298079357 0.5009492633 0.637157499 16 71864899 71864902 4 - 0.297 0.150 -1.254
ENSG00000102984 E018 62.9218152 0.0004711524 0.3750218913 0.519449033 16 71864903 71865048 146 - 1.791 1.742 -0.164
ENSG00000102984 E019 14.5585881 0.0013148256 0.1505339598 0.262402877 16 71867893 71867911 19 - 1.238 1.100 -0.493
ENSG00000102984 E020 63.2934213 0.0006717135 0.0209261019 0.053432720 16 71867912 71868037 126 - 1.837 1.723 -0.383
ENSG00000102984 E021 0.1451727 0.0459451841 0.2158683550   16 71879877 71879906 30 - 0.174 0.000 -13.352
ENSG00000102984 E022 55.6877648 0.0005180705 0.0229140562 0.057563009 16 71879907 71880007 101 - 1.780 1.661 -0.402
ENSG00000102984 E023 25.6070764 0.0237235969 0.1845580068 0.306930261 16 71880008 71880023 16 - 1.465 1.324 -0.489
ENSG00000102984 E024 0.6653823 0.0172671820 0.0715503463 0.145912705 16 71880024 71880065 42 - 0.395 0.084 -2.787
ENSG00000102984 E025 1.8026241 0.0081333665 0.6885558047 0.790651406 16 71880423 71880476 54 - 0.474 0.398 -0.397
ENSG00000102984 E026 9.0169981 0.0044720232 0.0872660216 0.170991219 16 71881317 71881434 118 - 1.092 0.895 -0.729
ENSG00000102984 E027 29.0428684 0.0273854590 0.0855629600 0.168312247 16 71883211 71883273 63 - 1.545 1.368 -0.610
ENSG00000102984 E028 0.1451727 0.0459451841 0.2158683550   16 71883274 71883422 149 - 0.174 0.000 -13.352
ENSG00000102984 E029 0.1817044 0.0416857209 1.0000000000   16 71883423 71883585 163 - 0.000 0.084 10.618
ENSG00000102984 E030 23.7548761 0.0479074626 0.0363847664 0.084316826 16 71883908 71884204 297 - 1.513 1.252 -0.903
ENSG00000102984 E031 1.3682533 0.0998850996 0.4051252075 0.548802570 16 71884594 71884809 216 - 0.474 0.312 -0.910
ENSG00000102984 E032 2.3466905 0.0193767685 0.0477815751 0.105229779 16 71894889 71895336 448 - 0.174 0.554 2.385