ENSG00000102967

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000219240 ENSG00000102967 HEK293_OSMI2_2hA HEK293_TMG_2hB DHODH protein_coding protein_coding 9.342813 13.18562 8.403855 0.8949696 0.2895434 -0.6492202 4.5276990 7.4512077 3.4452519 0.14214159 0.02830547 -1.1106183 0.48010833 0.5694667 0.41110000 -0.15836667 0.01591069 0.01591069 FALSE TRUE
ENST00000573922 ENSG00000102967 HEK293_OSMI2_2hA HEK293_TMG_2hB DHODH protein_coding processed_transcript 9.342813 13.18562 8.403855 0.8949696 0.2895434 -0.6492202 1.6947863 1.7407938 2.4274720 1.16681364 0.20910385 0.4773765 0.18305833 0.1226000 0.29080000 0.16820000 0.50447446 0.01591069 FALSE TRUE
ENST00000576145 ENSG00000102967 HEK293_OSMI2_2hA HEK293_TMG_2hB DHODH protein_coding protein_coding 9.342813 13.18562 8.403855 0.8949696 0.2895434 -0.6492202 0.9758202 1.9627277 0.5297330 0.41991027 0.29435345 -1.8698739 0.09800833 0.1489333 0.06113333 -0.08780000 0.48898615 0.01591069 FALSE FALSE
MSTRG.12977.12 ENSG00000102967 HEK293_OSMI2_2hA HEK293_TMG_2hB DHODH protein_coding   9.342813 13.18562 8.403855 0.8949696 0.2895434 -0.6492202 0.7897532 0.4967961 0.8952908 0.09342265 0.22258888 0.8369757 0.09036250 0.0383000 0.10826667 0.06996667 0.08143151 0.01591069   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102967 E001 1.8477626 0.0608320980 9.848318e-01 0.9945808584 16 72008588 72008743 156 + 0.398 0.399 0.004
ENSG00000102967 E002 1.6199747 0.0091583976 8.316429e-01 0.8944869231 16 72008744 72008745 2 + 0.398 0.357 -0.235
ENSG00000102967 E003 29.6318728 0.0006666331 2.578304e-02 0.0634955047 16 72008746 72008768 23 + 1.538 1.386 -0.522
ENSG00000102967 E004 45.6774755 0.0005050903 1.359282e-01 0.2423874982 16 72008769 72008777 9 + 1.672 1.586 -0.293
ENSG00000102967 E005 54.6724317 0.0005196277 2.254706e-01 0.3569663829 16 72008778 72008785 8 + 1.732 1.666 -0.223
ENSG00000102967 E006 4.8105296 0.0083933046 3.739526e-01 0.5183747077 16 72008801 72009147 347 + 0.602 0.737 0.574
ENSG00000102967 E007 122.1294740 0.0006055409 5.581472e-01 0.6864272365 16 72012050 72012232 183 + 2.049 2.024 -0.082
ENSG00000102967 E008 69.6119249 0.0020193797 5.930156e-01 0.7154701350 16 72012233 72012262 30 + 1.774 1.797 0.078
ENSG00000102967 E009 2.5777788 0.0080183917 6.526521e-02 0.1354813439 16 72013584 72013770 187 + 0.699 0.396 -1.427
ENSG00000102967 E010 0.8104413 0.6107634467 2.373426e-01 0.3710959706 16 72014419 72014450 32 + 0.476 0.087 -3.177
ENSG00000102967 E011 1.4037289 0.0877461795 4.657653e-02 0.1030755699 16 72014451 72014472 22 + 0.602 0.213 -2.243
ENSG00000102967 E012 167.2166573 0.0002590902 3.163474e-01 0.4591012279 16 72014473 72014672 200 + 2.150 2.177 0.087
ENSG00000102967 E013 0.9556140 0.2269819286 3.480008e-02 0.0812618051 16 72015623 72015683 61 + 0.543 0.085 -3.534
ENSG00000102967 E014 4.5809108 0.0334001938 1.339364e-02 0.0368297409 16 72015684 72015858 175 + 0.954 0.572 -1.547
ENSG00000102967 E015 4.5017333 0.0034702090 1.975123e-05 0.0001226462 16 72015859 72017023 1165 + 1.041 0.463 -2.390
ENSG00000102967 E016 117.6448761 0.0002956057 9.625274e-01 0.9803652450 16 72017024 72017106 83 + 2.023 2.018 -0.017
ENSG00000102967 E017 9.1374240 0.0408929238 2.070448e-03 0.0074426041 16 72019583 72019910 328 + 1.231 0.797 -1.604
ENSG00000102967 E018 2.4712301 0.0090904945 8.405227e-03 0.0248013364 16 72020041 72020401 361 + 0.778 0.356 -1.976
ENSG00000102967 E019 2.6195073 0.0309117810 4.548368e-01 0.5954229250 16 72020402 72020498 97 + 0.602 0.465 -0.644
ENSG00000102967 E020 120.1504150 0.0002732747 9.045486e-03 0.0263904926 16 72021124 72021311 188 + 1.959 2.049 0.304
ENSG00000102967 E021 98.9539215 0.0003623746 4.934923e-01 0.6305168169 16 72022362 72022475 114 + 1.924 1.947 0.078
ENSG00000102967 E022 130.2448542 0.0002473598 3.374997e-01 0.4813878330 16 72023165 72023318 154 + 2.039 2.068 0.096
ENSG00000102967 E023 1.2511813 0.0101454244 2.413754e-01 0.3757949124 16 72023319 72023323 5 + 0.477 0.266 -1.239
ENSG00000102967 E024 64.6097432 0.0003866373 3.776249e-01 0.5219414890 16 72023474 72023479 6 + 1.732 1.771 0.133
ENSG00000102967 E025 148.4716837 0.0002687323 6.217260e-03 0.0191865211 16 72023480 72023633 154 + 2.055 2.139 0.284
ENSG00000102967 E026 413.5609656 0.0017115417 4.819256e-01 0.6201095537 16 72024145 72027664 3520 + 2.574 2.556 -0.061