ENSG00000102935

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000562871 ENSG00000102935 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF423 protein_coding protein_coding 1.79683 2.570181 1.876379 0.1480119 0.1227246 -0.4518522 0.5783128 1.3865996 0.00000000 0.41906098 0.00000000 -7.1257746 0.29641250 0.53483333 0.0000000 -0.534833333 3.057886e-06 3.057886e-06 FALSE TRUE
ENST00000563137 ENSG00000102935 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF423 protein_coding protein_coding 1.79683 2.570181 1.876379 0.1480119 0.1227246 -0.4518522 0.1211289 0.1812339 0.19538897 0.01881628 0.01412913 0.1030202 0.06671250 0.07060000 0.1042667 0.033666667 6.180721e-01 3.057886e-06 FALSE TRUE
ENST00000567169 ENSG00000102935 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF423 protein_coding protein_coding 1.79683 2.570181 1.876379 0.1480119 0.1227246 -0.4518522 0.1560636 0.2306083 0.32996982 0.23060828 0.32996982 0.4987204 0.09832917 0.09073333 0.1572000 0.066466667 9.955258e-01 3.057886e-06 FALSE TRUE
ENST00000568094 ENSG00000102935 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF423 protein_coding protein_coding 1.79683 2.570181 1.876379 0.1480119 0.1227246 -0.4518522 0.1669592 0.1086826 0.06721183 0.06119571 0.06721183 -0.6202145 0.07870417 0.04123333 0.0401000 -0.001133333 8.067225e-01 3.057886e-06 FALSE FALSE
MSTRG.12596.6 ENSG00000102935 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF423 protein_coding   1.79683 2.570181 1.876379 0.1480119 0.1227246 -0.4518522 0.6987933 0.6354441 1.24532833 0.19552538 0.24044936 0.9597006 0.40124583 0.25236667 0.6780333 0.425666667 8.381792e-02 3.057886e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102935 E001 7.7293735 0.0030920227 1.386149e-01 0.2461814903 16 49487524 49490604 3081 - 1.026 0.834 -0.721
ENSG00000102935 E002 5.1027755 0.0061908496 4.854168e-02 0.1065828564 16 49490605 49490786 182 - 0.559 0.834 1.152
ENSG00000102935 E003 6.7957238 0.0030390073 2.544715e-05 0.0001540121 16 49490787 49490950 164 - 0.364 0.988 2.737
ENSG00000102935 E004 10.2299759 0.0020650666 2.385145e-04 0.0011270260 16 49490951 49491028 78 - 0.693 1.118 1.626
ENSG00000102935 E005 31.6073922 0.0006681856 2.031977e-03 0.0073260006 16 49491029 49491274 246 - 1.350 1.531 0.625
ENSG00000102935 E006 19.5651638 0.0010715620 2.239188e-02 0.0564901933 16 49491275 49491304 30 - 1.162 1.330 0.590
ENSG00000102935 E007 30.2160527 0.0013854318 1.478688e-02 0.0400127074 16 49523624 49523739 116 - 1.367 1.509 0.490
ENSG00000102935 E008 35.2255821 0.0050163537 5.613893e-02 0.1199482439 16 49525363 49525494 132 - 1.455 1.563 0.369
ENSG00000102935 E009 24.3990582 0.0009006728 6.533230e-01 0.7638336752 16 49626170 49626254 85 - 1.367 1.377 0.035
ENSG00000102935 E010 190.8472152 0.0046087034 3.997002e-03 0.0131348441 16 49635660 49638874 3215 - 2.314 2.216 -0.326
ENSG00000102935 E011 0.0000000       16 49640738 49640852 115 -      
ENSG00000102935 E012 0.0000000       16 49664091 49664225 135 -      
ENSG00000102935 E013 0.8449086 0.0145259513 4.181419e-01 0.5614313846 16 49730576 49730770 195 - 0.157 0.294 1.151
ENSG00000102935 E014 21.1592068 0.0146426119 5.102163e-03 0.0162097839 16 49730771 49730971 201 - 1.480 1.207 -0.952
ENSG00000102935 E015 0.0000000       16 49780545 49780609 65 -      
ENSG00000102935 E016 9.1596903 0.0035069835 1.250250e-01 0.2271631448 16 49789487 49789546 60 - 1.092 0.905 -0.689
ENSG00000102935 E017 0.6255398 0.0183356146 6.198348e-01 0.7371355241 16 49804489 49804617 129 - 0.157 0.237 0.734
ENSG00000102935 E018 1.6252878 0.0084330790 1.449237e-01 0.2547386017 16 49822670 49822738 69 - 0.559 0.295 -1.432
ENSG00000102935 E019 2.5788506 0.0170134192 1.318363e-01 0.2366764832 16 49826763 49827010 248 - 0.693 0.431 -1.210
ENSG00000102935 E020 10.7988371 0.0019347992 8.348363e-03 0.0246612874 16 49855735 49856112 378 - 1.212 0.931 -1.022
ENSG00000102935 E021 0.0000000       16 49857741 49857919 179 -