ENSG00000102910

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285737 ENSG00000102910 HEK293_OSMI2_2hA HEK293_TMG_2hB LONP2 protein_coding protein_coding 15.80878 9.499009 19.84445 0.7914338 0.7838809 1.062096 0.8143335 0.4540385 1.412281 0.08890464 0.2294994 1.6158898 0.05033333 0.04770000 0.07110000 0.02340000 4.545651e-01 1.890966e-24 FALSE TRUE
ENST00000416006 ENSG00000102910 HEK293_OSMI2_2hA HEK293_TMG_2hB LONP2 protein_coding nonsense_mediated_decay 15.80878 9.499009 19.84445 0.7914338 0.7838809 1.062096 1.1680425 0.0000000 1.138497 0.00000000 0.5793996 6.8436035 0.05440000 0.00000000 0.05540000 0.05540000 2.646379e-01 1.890966e-24 TRUE TRUE
ENST00000535754 ENSG00000102910 HEK293_OSMI2_2hA HEK293_TMG_2hB LONP2 protein_coding protein_coding 15.80878 9.499009 19.84445 0.7914338 0.7838809 1.062096 4.6676515 4.5563241 5.129218 0.82982820 0.2390094 0.1705155 0.33645000 0.47140000 0.25993333 -0.21146667 7.109283e-03 1.890966e-24 FALSE TRUE
ENST00000566755 ENSG00000102910 HEK293_OSMI2_2hA HEK293_TMG_2hB LONP2 protein_coding nonsense_mediated_decay 15.80878 9.499009 19.84445 0.7914338 0.7838809 1.062096 3.9862979 2.6054399 3.668480 0.09855541 0.3821619 0.4920561 0.25702500 0.27666667 0.18500000 -0.09166667 5.910493e-02 1.890966e-24 FALSE TRUE
ENST00000570174 ENSG00000102910 HEK293_OSMI2_2hA HEK293_TMG_2hB LONP2 protein_coding nonsense_mediated_decay 15.80878 9.499009 19.84445 0.7914338 0.7838809 1.062096 1.7665021 0.0000000 3.568474 0.00000000 0.4247654 8.4832008 0.08065833 0.00000000 0.17870000 0.17870000 1.890966e-24 1.890966e-24 TRUE TRUE
MSTRG.12591.1 ENSG00000102910 HEK293_OSMI2_2hA HEK293_TMG_2hB LONP2 protein_coding   15.80878 9.499009 19.84445 0.7914338 0.7838809 1.062096 0.9496399 1.2536692 0.407354 0.26733042 0.2202121 -1.5982753 0.08285000 0.13610000 0.01973333 -0.11636667 1.117684e-01 1.890966e-24 TRUE TRUE
MSTRG.12591.3 ENSG00000102910 HEK293_OSMI2_2hA HEK293_TMG_2hB LONP2 protein_coding   15.80878 9.499009 19.84445 0.7914338 0.7838809 1.062096 2.0899843 0.4344648 3.759218 0.21831659 0.2585767 3.0841242 0.11195000 0.04663333 0.19050000 0.14386667 2.247667e-01 1.890966e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102910 E001 5.5067549 0.0029504497 9.745664e-03 2.813732e-02 16 48244300 48244314 15 + 0.913 0.590 -1.315
ENSG00000102910 E002 15.9485086 0.0011511665 6.540575e-04 2.730421e-03 16 48244315 48244332 18 + 1.317 1.054 -0.938
ENSG00000102910 E003 23.2011668 0.0370453400 3.447445e-02 8.066847e-02 16 48244333 48244354 22 + 1.454 1.241 -0.744
ENSG00000102910 E004 37.9047637 0.0244953617 8.494958e-02 1.673258e-01 16 48244355 48244387 33 + 1.632 1.510 -0.416
ENSG00000102910 E005 84.6878255 0.0033742006 2.703294e-07 2.524056e-06 16 48244388 48244621 234 + 2.006 1.799 -0.697
ENSG00000102910 E006 120.7112976 0.0003058024 5.610318e-10 8.714093e-09 16 48252131 48252365 235 + 2.143 1.978 -0.551
ENSG00000102910 E007 96.6860596 0.0063212548 1.815630e-03 6.649376e-03 16 48256610 48256741 132 + 2.032 1.907 -0.420
ENSG00000102910 E008 118.9082794 0.0044849748 1.387866e-03 5.266861e-03 16 48258618 48258740 123 + 2.115 2.011 -0.350
ENSG00000102910 E009 121.9023469 0.0050797643 4.235577e-04 1.864726e-03 16 48261424 48261587 164 + 2.134 2.012 -0.409
ENSG00000102910 E010 0.1472490 0.0433524144 6.910123e-01   16 48262776 48262777 2 + 0.099 0.000 -8.621
ENSG00000102910 E011 97.0140693 0.0029139666 1.202799e-04 6.152736e-04 16 48262778 48262872 95 + 2.039 1.911 -0.430
ENSG00000102910 E012 174.8436372 0.0019417452 2.445119e-07 2.304120e-06 16 48270016 48270274 259 + 2.294 2.161 -0.444
ENSG00000102910 E013 130.0882815 0.0004359826 7.787832e-04 3.182857e-03 16 48277338 48277479 142 + 2.141 2.077 -0.214
ENSG00000102910 E014 86.7378118 0.0010460474 3.613490e-01 5.057401e-01 16 48296015 48296084 70 + 1.936 1.943 0.024
ENSG00000102910 E015 101.5452538 0.0003310630 1.330706e-03 5.078224e-03 16 48296085 48296165 81 + 2.036 1.965 -0.238
ENSG00000102910 E016 140.1835814 0.0002951143 1.063839e-02 3.030285e-02 16 48299662 48299788 127 + 2.159 2.125 -0.113
ENSG00000102910 E017 155.3195623 0.0004095819 4.373731e-02 9.790970e-02 16 48303172 48303305 134 + 2.197 2.182 -0.050
ENSG00000102910 E018 119.9781830 0.0003644439 3.837632e-01 5.279604e-01 16 48334216 48334311 96 + 2.073 2.089 0.053
ENSG00000102910 E019 104.2868874 0.0003735131 5.329933e-03 1.682900e-02 16 48334312 48334358 47 + 2.042 1.987 -0.183
ENSG00000102910 E020 0.5975289 0.0288184733 8.486381e-02 1.671869e-01 16 48336393 48336498 106 + 0.307 0.000 -10.802
ENSG00000102910 E021 170.8935655 0.0004254347 6.827847e-01 7.861642e-01 16 48347507 48347714 208 + 2.220 2.254 0.112
ENSG00000102910 E022 1.0997676 0.0125783115 5.061295e-01 6.418072e-01 16 48348096 48348099 4 + 0.359 0.261 -0.637
ENSG00000102910 E023 150.9041790 0.0002398271 3.623054e-01 5.066969e-01 16 48348100 48348290 191 + 2.149 2.220 0.238
ENSG00000102910 E024 118.8882945 0.0002959392 1.521888e-01 2.646641e-01 16 48351581 48351685 105 + 2.038 2.129 0.306
ENSG00000102910 E025 101.2757403 0.0002721939 2.551373e-04 1.196676e-03 16 48351686 48351798 113 + 1.926 2.099 0.578
ENSG00000102910 E026 1003.1980481 0.0030306213 1.292319e-17 6.261532e-16 16 48351799 48355685 3887 + 2.885 3.115 0.766
ENSG00000102910 E027 52.4372668 0.0023541530 8.733363e-01 9.226163e-01 16 48355686 48356448 763 + 1.701 1.753 0.175
ENSG00000102910 E028 24.0485894 0.0009212157 1.796678e-02 4.706372e-02 16 48356449 48356664 216 + 1.295 1.504 0.723
ENSG00000102910 E029 17.7792344 0.0057140563 2.162512e-01 3.458978e-01 16 48356665 48356710 46 + 1.201 1.351 0.524
ENSG00000102910 E030 6.0516844 0.0027294482 1.583670e-02 4.237234e-02 16 48356711 48357349 639 + 0.662 1.003 1.337
ENSG00000102910 E031 28.9902272 0.0286978281 6.912287e-01 7.927404e-01 16 48361477 48361704 228 + 1.470 1.475 0.016
ENSG00000102910 E032 15.7208635 0.0665099366 5.164012e-01 6.509820e-01 16 48361705 48361759 55 + 1.235 1.198 -0.133
ENSG00000102910 E033 17.7654535 0.0185952083 5.449073e-01 6.753175e-01 16 48361760 48361853 94 + 1.222 1.326 0.366
ENSG00000102910 E034 73.9767468 0.0207650846 4.630381e-01 6.028826e-01 16 48361854 48363122 1269 + 1.823 1.924 0.339