ENSG00000102893

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299167 ENSG00000102893 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKB protein_coding protein_coding 10.52406 3.447518 17.37892 0.03479009 0.5565618 2.330359 2.7371319 1.2842405 3.530269 0.55481068 0.2141518 1.451753 0.2709500 0.36946667 0.20303333 -0.16643333 6.163736e-01 3.72715e-07 FALSE TRUE
ENST00000566037 ENSG00000102893 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKB protein_coding protein_coding 10.52406 3.447518 17.37892 0.03479009 0.5565618 2.330359 1.8165820 0.0000000 3.067641 0.00000000 0.8927535 8.265681 0.1049958 0.00000000 0.17376667 0.17376667 3.727150e-07 3.72715e-07 FALSE FALSE
ENST00000566044 ENSG00000102893 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKB protein_coding protein_coding 10.52406 3.447518 17.37892 0.03479009 0.5565618 2.330359 2.5118675 0.7836255 4.515936 0.47391196 0.6840400 2.511686 0.2300458 0.22956667 0.25823333 0.02866667 8.376705e-01 3.72715e-07 FALSE TRUE
MSTRG.12579.1 ENSG00000102893 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKB protein_coding   10.52406 3.447518 17.37892 0.03479009 0.5565618 2.330359 0.9075563 0.4225703 1.848989 0.07547724 0.9246966 2.103512 0.1110250 0.12296667 0.10990000 -0.01306667 8.738143e-01 3.72715e-07 FALSE TRUE
MSTRG.12579.4 ENSG00000102893 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKB protein_coding   10.52406 3.447518 17.37892 0.03479009 0.5565618 2.330359 0.5762689 0.3095455 1.158457 0.23007786 0.4330199 1.870511 0.0744875 0.09023333 0.06723333 -0.02300000 9.654574e-01 3.72715e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102893 E001 0.7447779 0.0964063276 2.898950e-01 4.306552e-01 16 47461123 47461294 172 + 0.261 0.000 -10.816
ENSG00000102893 E002 2.0850084 0.1309321284 3.974788e-02 9.055737e-02 16 47461295 47461325 31 + 0.519 0.000 -12.268
ENSG00000102893 E003 2.4161519 0.0404826154 1.155967e-01 2.136950e-01 16 47461326 47461328 3 + 0.540 0.216 -1.934
ENSG00000102893 E004 2.5613246 0.0089976398 8.070483e-02 1.606507e-01 16 47461329 47461330 2 + 0.560 0.216 -2.027
ENSG00000102893 E005 2.7064973 0.0057110051 6.397060e-02 1.333052e-01 16 47461331 47461335 5 + 0.579 0.216 -2.114
ENSG00000102893 E006 11.8503884 0.0048461236 1.278692e-03 4.905916e-03 16 47461336 47461349 14 + 1.114 0.687 -1.632
ENSG00000102893 E007 32.4307381 0.0007977733 2.482886e-05 1.507227e-04 16 47461350 47461426 77 + 1.512 1.182 -1.152
ENSG00000102893 E008 3.1864856 0.0857862183 8.539082e-01 9.096143e-01 16 47461427 47461504 78 + 0.578 0.553 -0.112
ENSG00000102893 E009 3.2255610 0.0130867664 4.264430e-01 5.692665e-01 16 47462112 47462340 229 + 0.597 0.468 -0.612
ENSG00000102893 E010 1.7756348 0.0691465961 4.473370e-02 9.971602e-02 16 47462341 47462452 112 + 0.473 0.000 -12.042
ENSG00000102893 E011 2.8139924 0.0054987402 5.131452e-02 1.114953e-01 16 47462667 47463097 431 + 0.597 0.216 -2.197
ENSG00000102893 E012 6.2526932 0.0025777194 1.343675e-01 2.402302e-01 16 47463098 47463713 616 + 0.840 0.626 -0.875
ENSG00000102893 E013 3.4301812 0.0045779290 7.241939e-01 8.177890e-01 16 47463714 47463881 168 + 0.597 0.554 -0.196
ENSG00000102893 E014 8.9163121 0.0028639372 3.066766e-01 4.488585e-01 16 47463882 47463898 17 + 0.949 0.833 -0.440
ENSG00000102893 E015 40.3698522 0.0005817042 2.523557e-05 1.528536e-04 16 47463899 47463993 95 + 1.598 1.309 -0.996
ENSG00000102893 E016 46.8596653 0.0032702566 1.790825e-03 6.570185e-03 16 47497399 47497488 90 + 1.648 1.449 -0.682
ENSG00000102893 E017 51.5527817 0.0006513468 4.806441e-03 1.539184e-02 16 47499756 47499894 139 + 1.681 1.530 -0.514
ENSG00000102893 E018 52.3794655 0.0004802659 4.758728e-05 2.695550e-04 16 47502991 47503090 100 + 1.703 1.468 -0.801
ENSG00000102893 E019 55.6141710 0.0004410833 1.071159e-03 4.204974e-03 16 47511665 47511772 108 + 1.718 1.546 -0.584
ENSG00000102893 E020 47.2572073 0.0005091518 9.542666e-03 2.764181e-02 16 47515521 47515601 81 + 1.645 1.504 -0.481
ENSG00000102893 E021 50.6001670 0.0004391001 1.519212e-02 4.092339e-02 16 47547433 47547548 116 + 1.670 1.546 -0.423
ENSG00000102893 E022 1.1198269 0.0782500003 2.335493e-01 3.666173e-01 16 47547549 47548164 616 + 0.220 0.467 1.551
ENSG00000102893 E023 0.9620705 0.0121989077 7.928805e-01 8.675525e-01 16 47562398 47562495 98 + 0.260 0.216 -0.347
ENSG00000102893 E024 38.5024164 0.0036884225 2.151280e-02 5.467015e-02 16 47580295 47580358 64 + 1.558 1.407 -0.521
ENSG00000102893 E025 46.0908789 0.0005180427 8.038363e-02 1.601633e-01 16 47587668 47587763 96 + 1.624 1.538 -0.292
ENSG00000102893 E026 72.6205299 0.0036442589 1.370612e-01 2.439963e-01 16 47588905 47589102 198 + 1.810 1.747 -0.211
ENSG00000102893 E027 0.6590396 0.0231784786 8.521577e-01 9.083663e-01 16 47590305 47590838 534 + 0.174 0.216 0.391
ENSG00000102893 E028 45.5259505 0.0139514150 3.552807e-01 4.996315e-01 16 47593500 47593557 58 + 1.608 1.550 -0.199
ENSG00000102893 E029 35.5118005 0.0221402944 3.979887e-01 5.417233e-01 16 47594137 47594149 13 + 1.506 1.441 -0.225
ENSG00000102893 E030 53.1777710 0.0039774441 2.650174e-01 4.030275e-01 16 47594150 47594214 65 + 1.675 1.626 -0.167
ENSG00000102893 E031 49.9182601 0.0005098311 2.224086e-02 5.617577e-02 16 47596373 47596427 55 + 1.663 1.546 -0.397
ENSG00000102893 E032 74.2692458 0.0003357867 4.814295e-04 2.089040e-03 16 47596428 47596531 104 + 1.838 1.682 -0.527
ENSG00000102893 E033 0.4439371 0.0215635619 5.608195e-01 6.887390e-01 16 47597804 47598036 233 + 0.174 0.000 -10.042
ENSG00000102893 E034 68.8323957 0.0003547985 2.107759e-04 1.010038e-03 16 47610826 47610920 95 + 1.809 1.633 -0.597
ENSG00000102893 E035 0.5922303 0.0179931621 8.590473e-01 9.130607e-01 16 47619130 47619429 300 + 0.174 0.216 0.387
ENSG00000102893 E036 1.6607768 0.0088186273 6.413645e-01 7.544150e-01 16 47633899 47633981 83 + 0.364 0.467 0.557
ENSG00000102893 E037 58.7031406 0.0004312238 1.461046e-03 5.510331e-03 16 47641035 47641090 56 + 1.738 1.577 -0.547
ENSG00000102893 E038 68.1150967 0.0003588119 8.077682e-02 1.607557e-01 16 47641599 47641692 94 + 1.786 1.721 -0.221
ENSG00000102893 E039 65.0588832 0.0005495681 3.533103e-01 4.975438e-01 16 47648533 47648616 84 + 1.760 1.736 -0.079
ENSG00000102893 E040 55.1464806 0.0004344881 3.974712e-01 5.412341e-01 16 47649100 47649204 105 + 1.687 1.664 -0.078
ENSG00000102893 E041 56.6693022 0.0003954874 7.020127e-01 8.009373e-01 16 47650544 47650626 83 + 1.690 1.693 0.012
ENSG00000102893 E042 0.0000000       16 47650830 47650830 1 +      
ENSG00000102893 E043 56.5699325 0.0004518821 5.767124e-01 7.020990e-01 16 47650831 47650921 91 + 1.676 1.731 0.186
ENSG00000102893 E044 40.9026895 0.0005626542 1.815364e-01 3.031605e-01 16 47660506 47660567 62 + 1.525 1.633 0.366
ENSG00000102893 E045 42.0355546 0.0006784138 5.195185e-01 6.536012e-01 16 47660657 47660702 46 + 1.548 1.613 0.220
ENSG00000102893 E046 76.7848308 0.0005482399 1.397291e-01 2.476519e-01 16 47660703 47660819 117 + 1.798 1.891 0.314
ENSG00000102893 E047 66.8427896 0.0004206942 3.289210e-01 4.724124e-01 16 47661719 47661800 82 + 1.743 1.816 0.247
ENSG00000102893 E048 56.2648831 0.0004245219 5.397950e-01 6.710317e-01 16 47663677 47663734 58 + 1.691 1.682 -0.032
ENSG00000102893 E049 4.3779693 0.0379224136 7.083785e-01 8.060362e-01 16 47663735 47664390 656 + 0.679 0.627 -0.225
ENSG00000102893 E050 1.3191260 0.0249372749 8.106778e-02 1.612156e-01 16 47664790 47664884 95 + 0.394 0.000 -11.626
ENSG00000102893 E051 1.4632665 0.2188511515 5.064015e-01 6.420533e-01 16 47664885 47664975 91 + 0.393 0.214 -1.207
ENSG00000102893 E052 6.9846970 0.0023657709 3.019355e-01 4.437608e-01 16 47664976 47665941 966 + 0.870 0.741 -0.505
ENSG00000102893 E053 57.4440961 0.0003986913 1.176648e-01 2.166132e-01 16 47665942 47666032 91 + 1.669 1.776 0.362
ENSG00000102893 E054 81.2212116 0.0028489350 1.987116e-02 5.121812e-02 16 47669215 47669417 203 + 1.806 1.945 0.470
ENSG00000102893 E055 1.2072627 0.0301634165 8.051668e-01 8.760471e-01 16 47675586 47676409 824 + 0.298 0.359 0.387
ENSG00000102893 E056 84.7730878 0.0038853850 1.024831e-02 2.937679e-02 16 47689041 47689175 135 + 1.822 1.978 0.524
ENSG00000102893 E057 107.5602237 0.0012654894 6.824307e-04 2.834936e-03 16 47693378 47693507 130 + 1.924 2.087 0.546
ENSG00000102893 E058 86.3748862 0.0003247164 9.947508e-04 3.940132e-03 16 47696381 47696471 91 + 1.829 1.993 0.550
ENSG00000102893 E059 52.5672116 0.0007217329 9.088586e-02 1.765456e-01 16 47696472 47696488 17 + 1.629 1.747 0.400
ENSG00000102893 E060 108.0561266 0.0002788037 7.668683e-04 3.139405e-03 16 47698448 47698588 141 + 1.928 2.080 0.510
ENSG00000102893 E061 0.3729606 0.0331162026 3.375084e-01 4.813922e-01 16 47699156 47699228 73 + 0.066 0.217 1.976
ENSG00000102893 E062 263.9817386 0.0084384372 2.683959e-08 3.050747e-07 16 47699229 47701523 2295 + 2.269 2.552 0.944