ENSG00000102858

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262370 ENSG00000102858 HEK293_OSMI2_2hA HEK293_TMG_2hB MGRN1 protein_coding protein_coding 33.07521 44.8176 24.04599 4.872647 0.3400308 -0.8979912 8.533534 14.454552 4.198992 1.7718340 0.7198225 -1.7809749 0.23783333 0.33050000 0.1752667 -0.15523333 0.10521532 0.01448269 FALSE TRUE
ENST00000415496 ENSG00000102858 HEK293_OSMI2_2hA HEK293_TMG_2hB MGRN1 protein_coding protein_coding 33.07521 44.8176 24.04599 4.872647 0.3400308 -0.8979912 2.055983 2.080092 1.714176 0.2384127 0.1677821 -0.2776595 0.06524583 0.04636667 0.0713000 0.02493333 0.07507147 0.01448269 FALSE TRUE
ENST00000536343 ENSG00000102858 HEK293_OSMI2_2hA HEK293_TMG_2hB MGRN1 protein_coding nonsense_mediated_decay 33.07521 44.8176 24.04599 4.872647 0.3400308 -0.8979912 2.336530 1.452540 4.119689 0.7133251 0.9843920 1.4975571 0.07767917 0.03066667 0.1705000 0.13983333 0.01448269 0.01448269 TRUE TRUE
ENST00000588994 ENSG00000102858 HEK293_OSMI2_2hA HEK293_TMG_2hB MGRN1 protein_coding protein_coding 33.07521 44.8176 24.04599 4.872647 0.3400308 -0.8979912 8.408645 12.841835 4.968762 2.1363485 0.3193957 -1.3681153 0.24983333 0.28466667 0.2067000 -0.07796667 0.13695512 0.01448269 FALSE TRUE
ENST00000590790 ENSG00000102858 HEK293_OSMI2_2hA HEK293_TMG_2hB MGRN1 protein_coding protein_coding 33.07521 44.8176 24.04599 4.872647 0.3400308 -0.8979912 3.154759 1.560175 4.188284 1.5601752 0.3086402 1.4188742 0.10868750 0.03020000 0.1745667 0.14436667 0.07392094 0.01448269 FALSE TRUE
MSTRG.11980.3 ENSG00000102858 HEK293_OSMI2_2hA HEK293_TMG_2hB MGRN1 protein_coding   33.07521 44.8176 24.04599 4.872647 0.3400308 -0.8979912 4.509514 7.411544 2.978861 2.3984965 0.4340211 -1.3121236 0.13270417 0.15913333 0.1234667 -0.03566667 0.75130486 0.01448269 FALSE TRUE
MSTRG.11980.7 ENSG00000102858 HEK293_OSMI2_2hA HEK293_TMG_2hB MGRN1 protein_coding   33.07521 44.8176 24.04599 4.872647 0.3400308 -0.8979912 1.102421 2.771499 0.000000 1.3859468 0.0000000 -8.1197190 0.03010000 0.06830000 0.0000000 -0.06830000 0.21966332 0.01448269 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102858 E001 2.2509122 0.0541860662 6.937310e-01 7.947345e-01 16 4616493 4616575 83 + 0.387 0.480 0.488
ENSG00000102858 E002 2.7500476 0.1410224003 2.777369e-02 6.756696e-02 16 4624824 4624825 2 + 0.797 0.370 -1.970
ENSG00000102858 E003 8.4830853 0.2117724793 5.013147e-02 1.093990e-01 16 4624826 4624841 16 + 1.158 0.792 -1.369
ENSG00000102858 E004 11.3083481 0.2829917369 5.033477e-02 1.097567e-01 16 4624842 4624845 4 + 1.293 0.886 -1.477
ENSG00000102858 E005 15.3880355 0.2483591535 7.860823e-02 1.572654e-01 16 4624846 4624851 6 + 1.371 1.051 -1.134
ENSG00000102858 E006 20.8958531 0.1158695497 3.150586e-02 7.489134e-02 16 4624852 4624855 4 + 1.487 1.180 -1.073
ENSG00000102858 E007 34.9746792 0.0410016820 8.473190e-03 2.496882e-02 16 4624856 4624867 12 + 1.672 1.417 -0.872
ENSG00000102858 E008 99.9390441 0.0108586488 2.175617e-04 1.039087e-03 16 4624868 4624960 93 + 2.086 1.886 -0.669
ENSG00000102858 E009 140.6286366 0.0019434366 2.764957e-06 2.086073e-05 16 4624961 4625048 88 + 2.203 2.049 -0.516
ENSG00000102858 E010 0.9179615 0.0185835045 3.316445e-01 4.752834e-01 16 4649080 4650364 1285 + 0.387 0.220 -1.121
ENSG00000102858 E011 107.0867158 0.0018948078 1.619516e-06 1.285186e-05 16 4650365 4650386 22 + 2.099 1.923 -0.590
ENSG00000102858 E012 99.1057832 0.0012703708 1.112718e-05 7.315420e-05 16 4650387 4650399 13 + 2.056 1.897 -0.532
ENSG00000102858 E013 182.1047654 0.0016379356 7.963885e-07 6.755324e-06 16 4650400 4650483 84 + 2.308 2.165 -0.480
ENSG00000102858 E014 0.5514428 0.0196303565 2.990541e-01 4.405372e-01 16 4650484 4651106 623 + 0.000 0.221 10.334
ENSG00000102858 E015 204.4083400 0.0009502878 2.893198e-06 2.172358e-05 16 4651963 4652051 89 + 2.341 2.222 -0.396
ENSG00000102858 E016 314.9418451 0.0019566574 4.855093e-04 2.104718e-03 16 4652678 4652824 147 + 2.503 2.423 -0.266
ENSG00000102858 E017 251.5212415 0.0001676549 2.375622e-04 1.123198e-03 16 4657246 4657311 66 + 2.398 2.327 -0.236
ENSG00000102858 E018 218.4753425 0.0001696404 2.055610e-05 1.271634e-04 16 4657312 4657363 52 + 2.352 2.261 -0.305
ENSG00000102858 E019 0.2214452 0.0378783197 1.000000e+00   16 4664069 4664286 218 + 0.000 0.087 8.477
ENSG00000102858 E020 0.7686361 0.0887714678 6.812881e-01 7.850224e-01 16 4664416 4664708 293 + 0.292 0.219 -0.545
ENSG00000102858 E021 269.9374866 0.0001620434 6.621536e-04 2.760131e-03 16 4664709 4664775 67 + 2.422 2.361 -0.205
ENSG00000102858 E022 16.7987139 0.0010911078 7.227717e-01 8.168247e-01 16 4665099 4665101 3 + 1.213 1.199 -0.053
ENSG00000102858 E023 251.2879694 0.0002032984 2.165691e-02 5.496392e-02 16 4665102 4665151 50 + 2.376 2.337 -0.128
ENSG00000102858 E024 225.1901067 0.0002432127 8.310956e-03 2.457024e-02 16 4668265 4668296 32 + 2.338 2.288 -0.168
ENSG00000102858 E025 185.0458221 0.0002476525 9.314663e-06 6.234799e-05 16 4668297 4668312 16 + 2.291 2.184 -0.355
ENSG00000102858 E026 2.3541686 0.0064982858 3.423962e-01 4.864046e-01 16 4669121 4669252 132 + 0.589 0.442 -0.703
ENSG00000102858 E027 177.3803237 0.0025821574 1.057176e-02 3.014158e-02 16 4671391 4671404 14 + 2.253 2.179 -0.246
ENSG00000102858 E028 222.1204828 0.0018792706 3.844970e-02 8.819262e-02 16 4671405 4671459 55 + 2.330 2.283 -0.156
ENSG00000102858 E029 2.2498826 0.0069876302 2.484071e-01 3.840471e-01 16 4672400 4672516 117 + 0.589 0.406 -0.895
ENSG00000102858 E030 324.5244558 0.0026714740 9.671182e-01 9.833968e-01 16 4673498 4673657 160 + 2.443 2.468 0.083
ENSG00000102858 E031 2.4938523 0.0374451654 1.454127e-01 2.554142e-01 16 4676921 4677462 542 + 0.292 0.586 1.572
ENSG00000102858 E032 213.2105704 0.0021941878 1.346171e-01 2.405743e-01 16 4677463 4677572 110 + 2.223 2.297 0.250
ENSG00000102858 E033 89.1413601 0.0008541658 9.190550e-01 9.528752e-01 16 4680032 4680097 66 + 1.888 1.902 0.048
ENSG00000102858 E034 2.5798566 0.0127265306 1.115781e-02 3.154427e-02 16 4680173 4680275 103 + 0.763 0.367 -1.855
ENSG00000102858 E035 8.2459091 0.0020306501 5.012429e-03 1.596512e-02 16 4680428 4680676 249 + 1.114 0.814 -1.118
ENSG00000102858 E036 7.0010534 0.0028948664 3.648486e-01 5.091861e-01 16 4681348 4681549 202 + 0.913 0.815 -0.380
ENSG00000102858 E037 323.4357840 0.0001563336 4.012305e-01 5.449312e-01 16 4681550 4681776 227 + 2.430 2.467 0.123
ENSG00000102858 E038 234.7671227 0.0009282845 4.516144e-01 5.925533e-01 16 4682823 4682946 124 + 2.289 2.331 0.137
ENSG00000102858 E039 157.7604218 0.0021044029 4.902862e-01 6.276319e-01 16 4683224 4683269 46 + 2.114 2.160 0.154
ENSG00000102858 E040 211.4054927 0.0002256602 4.755780e-02 1.048320e-01 16 4683843 4683932 90 + 2.218 2.291 0.245
ENSG00000102858 E041 50.7332441 0.0005741279 2.606459e-02 6.407976e-02 16 4686259 4686303 45 + 1.551 1.696 0.494
ENSG00000102858 E042 137.9459815 0.0025723370 1.917860e-08 2.244319e-07 16 4686304 4688795 2492 + 2.225 2.025 -0.669
ENSG00000102858 E043 1200.2899864 0.0004598136 3.380735e-28 4.863099e-26 16 4688796 4689909 1114 + 2.892 3.070 0.594
ENSG00000102858 E044 519.8841158 0.0026171671 1.990890e-15 7.233757e-14 16 4689910 4690234 325 + 2.460 2.724 0.881
ENSG00000102858 E045 513.8317049 0.0120774512 2.245210e-05 1.375997e-04 16 4690235 4691551 1317 + 2.462 2.720 0.857