ENSG00000102753

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261667 ENSG00000102753 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA3 protein_coding protein_coding 21.24806 8.436086 34.73008 0.2493584 1.447145 2.040246 18.2435450 7.8684995 30.871865 0.48329152 1.5026086 1.970767 0.87075417 0.93093333 0.88856667 -0.04236667 0.4896604929 0.0008356265 FALSE  
MSTRG.8772.1 ENSG00000102753 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA3 protein_coding   21.24806 8.436086 34.73008 0.2493584 1.447145 2.040246 0.1456916 0.4248145 0.000000 0.27200597 0.0000000 -5.442328 0.01501250 0.05240000 0.00000000 -0.05240000 0.0733737521 0.0008356265 FALSE  
MSTRG.8772.3 ENSG00000102753 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA3 protein_coding   21.24806 8.436086 34.73008 0.2493584 1.447145 2.040246 2.5596149 0.1194358 3.468862 0.07640914 0.4449883 4.748307 0.08680417 0.01396667 0.09946667 0.08550000 0.0008356265 0.0008356265 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102753 E001 770.423366 0.0037573786 1.382518e-03 5.249300e-03 13 49699320 49701134 1815 - 2.794 2.904 0.365
ENSG00000102753 E002 92.818116 0.0041515731 2.332949e-01 3.663303e-01 13 49701135 49701209 75 - 1.922 1.876 -0.155
ENSG00000102753 E003 132.290459 0.0019813730 1.510864e-02 4.073324e-02 13 49701210 49701407 198 - 2.031 2.145 0.383
ENSG00000102753 E004 138.956484 0.0013236126 9.652717e-07 8.033909e-06 13 49701408 49701527 120 - 2.025 2.221 0.657
ENSG00000102753 E005 301.187174 0.0004017468 1.902816e-12 4.454255e-11 13 49701528 49701855 328 - 2.362 2.545 0.609
ENSG00000102753 E006 124.819714 0.0002607142 1.574298e-09 2.251084e-08 13 49701856 49701898 43 - 1.969 2.195 0.756
ENSG00000102753 E007 169.027170 0.0002206006 1.489718e-07 1.463127e-06 13 49702386 49702480 95 - 2.116 2.292 0.588
ENSG00000102753 E008 211.238563 0.0011043783 1.321815e-01 2.371434e-01 13 49705621 49705783 163 - 2.247 2.312 0.217
ENSG00000102753 E009 171.257181 0.0039414279 3.303318e-01 4.739297e-01 13 49706098 49706169 72 - 2.179 2.154 -0.083
ENSG00000102753 E010 174.679961 0.0002375974 5.190149e-04 2.231128e-03 13 49706268 49706372 105 - 2.203 2.109 -0.317
ENSG00000102753 E011 219.888314 0.0001838873 6.282557e-06 4.374009e-05 13 49709572 49709700 129 - 2.305 2.191 -0.379
ENSG00000102753 E012 180.723291 0.0002614951 5.490342e-03 1.726269e-02 13 49710891 49711022 132 - 2.211 2.141 -0.235
ENSG00000102753 E013 114.612061 0.0020094547 4.500272e-01 5.911996e-01 13 49719775 49719819 45 - 2.002 1.988 -0.049
ENSG00000102753 E014 222.327930 0.0001957950 3.110802e-04 1.424678e-03 13 49721955 49722124 170 - 2.305 2.220 -0.284
ENSG00000102753 E015 163.415033 0.0002309233 2.697382e-07 2.519902e-06 13 49722477 49722563 87 - 2.187 2.028 -0.535
ENSG00000102753 E016 152.049952 0.0002436692 1.031694e-03 4.067833e-03 13 49725416 49725501 86 - 2.144 2.047 -0.322
ENSG00000102753 E017 134.508084 0.0002229070 1.055137e-05 6.976888e-05 13 49732371 49732466 96 - 2.101 1.953 -0.498
ENSG00000102753 E018 109.194072 0.0003110634 1.753653e-05 1.101685e-04 13 49732605 49732657 53 - 2.012 1.847 -0.555
ENSG00000102753 E019 96.344022 0.0052206368 6.642660e-03 2.029598e-02 13 49732747 49732776 30 - 1.953 1.814 -0.467
ENSG00000102753 E020 132.136042 0.0005952035 2.066566e-05 1.277673e-04 13 49732957 49733046 90 - 2.091 1.941 -0.505
ENSG00000102753 E021 94.816161 0.0003081112 7.229555e-04 2.981059e-03 13 49746949 49746993 45 - 1.945 1.811 -0.451
ENSG00000102753 E022 89.075031 0.0003152448 2.434466e-03 8.564890e-03 13 49792438 49792565 128 - 1.916 1.794 -0.410
ENSG00000102753 E023 7.619071 0.0039411375 5.340603e-01 6.661806e-01 13 49792566 49792682 117 - 0.891 0.821 -0.270
ENSG00000102753 E024 5.736530 0.0183157664 4.546015e-01 5.952259e-01 13 49792889 49793049 161 - 0.733 0.861 0.506