ENSG00000102743

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338625 ENSG00000102743 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A15 protein_coding protein_coding 19.99328 22.45782 20.27523 4.711905 0.9452759 -0.1474305 12.677702 12.082148 13.697487 1.7632143 0.1880534 0.1808935 0.64979583 0.55423333 0.6789667 0.12473333 0.22366182 0.0450276 FALSE TRUE
ENST00000384919 ENSG00000102743 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A15 protein_coding miRNA 19.99328 22.45782 20.27523 4.711905 0.9452759 -0.1474305 3.897931 7.412723 1.323281 2.7409489 0.6757190 -2.4769680 0.17761250 0.30853333 0.0628000 -0.24573333 0.25439777 0.0450276   FALSE
ENST00000478827 ENSG00000102743 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A15 protein_coding processed_transcript 19.99328 22.45782 20.27523 4.711905 0.9452759 -0.1474305 1.086046 1.120708 2.226915 0.2146949 0.3636785 0.9842838 0.05712917 0.05233333 0.1087667 0.05643333 0.05006912 0.0450276 TRUE FALSE
MSTRG.8629.2 ENSG00000102743 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A15 protein_coding   19.99328 22.45782 20.27523 4.711905 0.9452759 -0.1474305 2.312654 1.842239 3.027547 0.2664811 0.3768711 0.7136366 0.11436250 0.08490000 0.1494667 0.06456667 0.04502760 0.0450276 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102743 E001 0.4396707 0.0281391666 7.094379e-02 0.1449050417 13 40789412 40789412 1 + 0.296 0.000 -9.814
ENSG00000102743 E002 46.0707336 0.0035080771 1.404992e-04 0.0007056694 13 40789413 40789610 198 + 1.761 1.590 -0.580
ENSG00000102743 E003 61.6075649 0.0037739974 4.499553e-05 0.0002563304 13 40789611 40789663 53 + 1.882 1.715 -0.566
ENSG00000102743 E004 109.1056750 0.0022850510 2.305751e-04 0.0010940956 13 40793158 40793281 124 + 2.095 1.998 -0.325
ENSG00000102743 E005 123.0864552 0.0003410129 7.965379e-05 0.0004262279 13 40799057 40799172 116 + 2.135 2.065 -0.235
ENSG00000102743 E006 150.7173800 0.0008615345 1.292491e-02 0.0357358542 13 40799173 40799315 143 + 2.198 2.173 -0.082
ENSG00000102743 E007 3.5709937 0.0105483858 7.071214e-01 0.8051231519 13 40802135 40802300 166 + 0.595 0.691 0.413
ENSG00000102743 E008 140.3221628 0.0021985453 5.653856e-01 0.6924971189 13 40805118 40805255 138 + 2.138 2.167 0.097
ENSG00000102743 E009 157.5435546 0.0018762068 4.901892e-01 0.6275395080 13 40807294 40807463 170 + 2.190 2.216 0.086
ENSG00000102743 E010 171.9518683 0.0003611993 8.212574e-02 0.1628767449 13 40808438 40808596 159 + 2.240 2.247 0.025
ENSG00000102743 E011 538.6768511 0.0005431815 4.513471e-02 0.1004404734 13 40809543 40810765 1223 + 2.727 2.745 0.062
ENSG00000102743 E012 807.9046544 0.0069373566 7.699978e-05 0.0004138615 13 40810766 40812460 1695 + 2.809 2.975 0.553