ENSG00000102710

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360252 ENSG00000102710 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT20H protein_coding protein_coding 17.20008 12.42362 20.25613 0.9296789 0.7969449 0.7048246 0.5758245 1.5624791 0.0000000 0.2776718 0.00000000 -7.2968970 0.05190417 0.12493333 0.00000000 -0.12493333 2.541949e-21 2.541949e-21 FALSE TRUE
ENST00000466563 ENSG00000102710 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT20H protein_coding processed_transcript 17.20008 12.42362 20.25613 0.9296789 0.7969449 0.7048246 0.3083153 1.2609596 0.0000000 1.2609596 0.00000000 -6.9897744 0.01899583 0.08843333 0.00000000 -0.08843333 7.509441e-01 2.541949e-21 FALSE FALSE
ENST00000469488 ENSG00000102710 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT20H protein_coding protein_coding 17.20008 12.42362 20.25613 0.9296789 0.7969449 0.7048246 1.4290827 1.9758223 1.6193998 0.2618682 0.25258957 -0.2853959 0.09970000 0.16373333 0.07970000 -0.08403333 1.066417e-01 2.541949e-21 FALSE TRUE
ENST00000475892 ENSG00000102710 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT20H protein_coding protein_coding 17.20008 12.42362 20.25613 0.9296789 0.7969449 0.7048246 2.6718680 3.4710940 3.1135228 0.5280317 0.58409106 -0.1563667 0.18200000 0.28710000 0.15310000 -0.13400000 2.012776e-01 2.541949e-21 FALSE TRUE
ENST00000490716 ENSG00000102710 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT20H protein_coding nonsense_mediated_decay 17.20008 12.42362 20.25613 0.9296789 0.7969449 0.7048246 1.0345854 1.0930992 0.9095769 0.1685977 0.54340119 -0.2625204 0.06566667 0.08853333 0.04720000 -0.04133333 6.272932e-01 2.541949e-21 TRUE TRUE
ENST00000493537 ENSG00000102710 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT20H protein_coding retained_intron 17.20008 12.42362 20.25613 0.9296789 0.7969449 0.7048246 2.2098335 0.6966561 3.2601329 0.0999638 0.09176607 2.2102690 0.11731250 0.05603333 0.16146667 0.10543333 9.627296e-07 2.541949e-21 FALSE TRUE
MSTRG.8615.15 ENSG00000102710 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT20H protein_coding   17.20008 12.42362 20.25613 0.9296789 0.7969449 0.7048246 1.1299106 0.3482345 1.9685577 0.3482345 0.20800712 2.4654728 0.05042083 0.03096667 0.09713333 0.06616667 1.760484e-01 2.541949e-21 FALSE TRUE
MSTRG.8615.16 ENSG00000102710 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT20H protein_coding   17.20008 12.42362 20.25613 0.9296789 0.7969449 0.7048246 1.1536620 0.0000000 1.5322624 0.0000000 0.31307742 7.2689044 0.06104167 0.00000000 0.07630000 0.07630000 1.764780e-09 2.541949e-21 FALSE TRUE
MSTRG.8615.24 ENSG00000102710 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT20H protein_coding   17.20008 12.42362 20.25613 0.9296789 0.7969449 0.7048246 0.6865918 0.0000000 2.3482774 0.0000000 0.33422178 7.8815896 0.03130833 0.00000000 0.11516667 0.11516667 6.300216e-18 2.541949e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102710 E001 0.3666179 0.0281288951 8.169760e-01 8.842278e-01 13 37009312 37009315 4 - 0.107 0.140 0.450
ENSG00000102710 E002 15.4843816 0.0252412735 4.395526e-02 9.829655e-02 13 37009316 37009492 177 - 1.095 1.319 0.794
ENSG00000102710 E003 10.3654935 0.0044554861 5.510928e-02 1.181875e-01 13 37009493 37009493 1 - 0.945 1.144 0.728
ENSG00000102710 E004 11.4349678 0.0030681392 7.629819e-03 2.284749e-02 13 37009494 37009496 3 - 0.945 1.210 0.962
ENSG00000102710 E005 44.0520953 0.0026259722 1.681642e-08 1.987784e-07 13 37009497 37009613 117 - 1.465 1.792 1.113
ENSG00000102710 E006 27.0241197 0.0126401576 1.037808e-07 1.050939e-06 13 37009614 37009616 3 - 1.158 1.627 1.629
ENSG00000102710 E007 26.3660356 0.0067510800 6.065926e-11 1.108062e-09 13 37009617 37009625 9 - 1.104 1.633 1.841
ENSG00000102710 E008 31.5483880 0.0013344467 1.750099e-11 3.500327e-10 13 37009626 37009630 5 - 1.249 1.686 1.506
ENSG00000102710 E009 62.0930517 0.0027107325 3.551156e-08 3.940236e-07 13 37009631 37009702 72 - 1.643 1.922 0.944
ENSG00000102710 E010 46.8764893 0.0036597897 2.973560e-04 1.368972e-03 13 37009703 37009719 17 - 1.568 1.777 0.712
ENSG00000102710 E011 80.3413161 0.0010029181 1.709966e-07 1.660845e-06 13 37009720 37009809 90 - 1.795 2.009 0.721
ENSG00000102710 E012 31.0981697 0.0010174165 2.955069e-02 7.107766e-02 13 37010552 37010655 104 - 1.435 1.569 0.462
ENSG00000102710 E013 2.1496516 0.0069762252 2.971591e-01 4.384655e-01 13 37010656 37010852 197 - 0.578 0.401 -0.876
ENSG00000102710 E014 93.9938802 0.0009089479 1.809668e-07 1.748986e-06 13 37012192 37012297 106 - 1.871 2.069 0.666
ENSG00000102710 E015 2.0840754 0.0827989300 6.983394e-02 1.431010e-01 13 37012298 37013906 1609 - 0.610 0.248 -1.999
ENSG00000102710 E016 81.7337696 0.0003392371 2.281691e-08 2.631878e-07 13 37017245 37017328 84 - 1.800 2.017 0.728
ENSG00000102710 E017 46.1916206 0.0005106597 2.639467e-03 9.188685e-03 13 37017329 37017364 36 - 1.593 1.746 0.519
ENSG00000102710 E018 58.4271050 0.0005448832 5.890137e-03 1.832237e-02 13 37019342 37019397 56 - 1.709 1.834 0.423
ENSG00000102710 E019 83.9078138 0.0025321073 7.488224e-03 2.248212e-02 13 37021448 37021602 155 - 1.871 1.988 0.395
ENSG00000102710 E020 76.9244216 0.0003461538 1.284880e-01 2.320552e-01 13 37022011 37022080 70 - 1.863 1.921 0.197
ENSG00000102710 E021 58.8872056 0.0004250329 9.053145e-02 1.759670e-01 13 37022081 37022222 142 - 1.737 1.812 0.254
ENSG00000102710 E022 52.9322723 0.0004497625 2.665627e-03 9.269365e-03 13 37022223 37022317 95 - 1.656 1.799 0.483
ENSG00000102710 E023 32.4315403 0.0007415549 3.696828e-01 5.140771e-01 13 37022318 37022870 553 - 1.544 1.486 -0.198
ENSG00000102710 E024 18.6774360 0.0011761926 3.209480e-03 1.088327e-02 13 37022871 37023044 174 - 1.388 1.144 -0.857
ENSG00000102710 E025 26.8478037 0.0007347892 2.682708e-06 2.030235e-05 13 37023549 37024034 486 - 1.571 1.239 -1.150
ENSG00000102710 E026 114.8511969 0.0005733644 4.350001e-01 5.772305e-01 13 37024035 37024133 99 - 2.052 2.076 0.080
ENSG00000102710 E027 66.4660887 0.0185386266 8.377428e-01 8.985780e-01 13 37024134 37024150 17 - 1.838 1.819 -0.067
ENSG00000102710 E028 87.2505541 0.0033848313 7.195116e-01 8.143217e-01 13 37024151 37024193 43 - 1.954 1.934 -0.067
ENSG00000102710 E029 115.1141224 0.0003308611 3.180159e-01 4.609400e-01 13 37024340 37024442 103 - 2.080 2.045 -0.120
ENSG00000102710 E030 4.4912285 0.0036270961 6.977861e-04 2.891055e-03 13 37024443 37024947 505 - 0.916 0.401 -2.254
ENSG00000102710 E031 2.1078344 0.0085160005 2.979865e-01 4.393749e-01 13 37025191 37025319 129 - 0.578 0.401 -0.877
ENSG00000102710 E032 120.5158648 0.0021168717 1.844643e-01 3.068118e-01 13 37025320 37025437 118 - 2.109 2.056 -0.179
ENSG00000102710 E033 3.0750897 0.0053941507 3.832282e-02 8.795488e-02 13 37025830 37026203 374 - 0.737 0.401 -1.554
ENSG00000102710 E034 76.8112507 0.0019228673 7.727590e-01 8.533176e-01 13 37026204 37026236 33 - 1.898 1.882 -0.053
ENSG00000102710 E035 74.4693757 0.0022655037 6.486563e-01 7.601227e-01 13 37026790 37026816 27 - 1.888 1.865 -0.081
ENSG00000102710 E036 116.3746800 0.0004978706 4.364730e-01 5.785447e-01 13 37028148 37028305 158 - 2.083 2.055 -0.096
ENSG00000102710 E037 0.0000000       13 37028306 37028308 3 -      
ENSG00000102710 E038 74.6967857 0.0003906283 1.572778e-02 4.212197e-02 13 37029765 37029836 72 - 1.922 1.819 -0.344
ENSG00000102710 E039 67.6184536 0.0004205386 1.051020e-02 3.000310e-02 13 37031567 37031623 57 - 1.881 1.766 -0.385
ENSG00000102710 E040 105.2992856 0.0003378174 7.677770e-03 2.297183e-02 13 37031739 37031895 157 - 2.066 1.970 -0.321
ENSG00000102710 E041 103.6426782 0.0032654174 1.856655e-02 4.837810e-02 13 37033449 37033588 140 - 2.064 1.957 -0.358
ENSG00000102710 E042 0.2966881 0.0295220357 2.999402e-01   13 37038035 37040403 2369 - 0.192 0.000 -12.310
ENSG00000102710 E043 0.1515154 0.0428289690 6.473465e-01   13 37040404 37040404 1 - 0.107 0.000 -11.310
ENSG00000102710 E044 58.4106829 0.0007010925 5.436125e-03 1.711466e-02 13 37040405 37040416 12 - 1.830 1.696 -0.454
ENSG00000102710 E045 65.3576213 0.0108818548 4.097955e-02 9.284316e-02 13 37040417 37040458 42 - 1.879 1.742 -0.465
ENSG00000102710 E046 93.2556833 0.0003756800 1.298886e-05 8.401164e-05 13 37040576 37040692 117 - 2.040 1.874 -0.560
ENSG00000102710 E047 86.9369676 0.0003520755 1.004178e-02 2.886600e-02 13 37044078 37044181 104 - 1.984 1.882 -0.341
ENSG00000102710 E048 93.1195958 0.0045540662 1.485712e-02 4.016779e-02 13 37045247 37045373 127 - 2.022 1.903 -0.401
ENSG00000102710 E049 11.9959476 0.0014159732 3.989168e-01 5.426646e-01 13 37045374 37045376 3 - 1.149 1.066 -0.300
ENSG00000102710 E050 0.5879639 0.0198293756 4.814168e-01 6.196403e-01 13 37046864 37047345 482 - 0.264 0.140 -1.140
ENSG00000102710 E051 2.0284269 0.0070034330 1.536873e-01 2.666800e-01 13 37047346 37047408 63 - 0.578 0.330 -1.290
ENSG00000102710 E052 0.8836079 0.0139208676 2.081476e-02 5.320150e-02 13 37047409 37047534 126 - 0.427 0.000 -13.894
ENSG00000102710 E053 59.3838374 0.0004196411 2.858935e-06 2.149584e-05 13 37047535 37047601 67 - 1.869 1.647 -0.754
ENSG00000102710 E054 58.5957300 0.0141586504 9.748153e-04 3.873397e-03 13 37047878 37047936 59 - 1.873 1.625 -0.842
ENSG00000102710 E055 0.2987644 0.0270823773 2.998122e-01   13 37047937 37047937 1 - 0.192 0.000 -12.310
ENSG00000102710 E056 34.7957210 0.0007033754 5.099758e-06 3.622685e-05 13 37048564 37048599 36 - 1.662 1.377 -0.977
ENSG00000102710 E057 0.4815130 0.0219550681 4.009825e-01 5.446491e-01 13 37048600 37048600 1 - 0.107 0.245 1.445
ENSG00000102710 E058 51.5140915 0.0004961478 3.549203e-06 2.613745e-05 13 37051488 37051541 54 - 1.812 1.574 -0.807
ENSG00000102710 E059 40.1641121 0.0005441892 2.986223e-03 1.022301e-02 13 37051542 37051583 42 - 1.682 1.512 -0.579
ENSG00000102710 E060 8.3240036 0.0602050863 6.480324e-02 1.347202e-01 13 37054135 37054296 162 - 1.075 0.781 -1.114
ENSG00000102710 E061 0.0000000       13 37056878 37057133 256 -      
ENSG00000102710 E062 0.5975289 0.0261814234 7.467456e-02 1.510176e-01 13 37059195 37059361 167 - 0.325 0.000 -13.310
ENSG00000102710 E063 0.4439371 0.0215795223 1.440931e-01 2.535800e-01 13 37059362 37059468 107 - 0.264 0.000 -12.894
ENSG00000102710 E064 3.6214374 0.0042951686 1.214943e-02 3.389051e-02 13 37059480 37059558 79 - 0.799 0.402 -1.800
ENSG00000102710 E065 34.4615179 0.0006146775 1.507643e-02 4.066264e-02 13 37059559 37059713 155 - 1.608 1.459 -0.512