ENSG00000102595

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376747 ENSG00000102595 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT2 protein_coding protein_coding 8.030679 2.076806 15.73992 0.3715389 0.4169759 2.915977 3.5040873 1.18225589 6.0510425 0.10509842 0.33706768 2.3458720 0.48090000 0.58796667 0.38430000 -0.2036666667 2.908913e-02 8.059594e-09 FALSE TRUE
ENST00000397618 ENSG00000102595 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT2 protein_coding protein_coding 8.030679 2.076806 15.73992 0.3715389 0.4169759 2.915977 0.6949639 0.25724262 1.7991982 0.17388810 0.23829943 2.7591285 0.06164583 0.11163333 0.11390000 0.0022666667 9.176976e-01 8.059594e-09 FALSE TRUE
ENST00000461329 ENSG00000102595 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT2 protein_coding processed_transcript 8.030679 2.076806 15.73992 0.3715389 0.4169759 2.915977 0.4824441 0.09973404 0.8336848 0.09973404 0.49451839 2.9426930 0.07547500 0.05076667 0.05150000 0.0007333333 8.622414e-01 8.059594e-09 FALSE TRUE
ENST00000462472 ENSG00000102595 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT2 protein_coding processed_transcript 8.030679 2.076806 15.73992 0.3715389 0.4169759 2.915977 0.1681067 0.29483316 0.1997854 0.13077058 0.05555667 -0.5391054 0.04412917 0.12913333 0.01290000 -0.1162333333 4.490191e-05 8.059594e-09 FALSE FALSE
ENST00000465196 ENSG00000102595 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT2 protein_coding processed_transcript 8.030679 2.076806 15.73992 0.3715389 0.4169759 2.915977 1.3751252 0.00000000 3.4654356 0.00000000 0.50725362 8.4410500 0.09644583 0.00000000 0.22040000 0.2204000000 8.059594e-09 8.059594e-09 FALSE TRUE
ENST00000621375 ENSG00000102595 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT2 protein_coding protein_coding 8.030679 2.076806 15.73992 0.3715389 0.4169759 2.915977 0.2818532 0.00000000 1.1999177 0.00000000 0.61242677 6.9187652 0.01746667 0.00000000 0.07756667 0.0775666667 4.785544e-01 8.059594e-09 FALSE TRUE
MSTRG.8968.2 ENSG00000102595 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT2 protein_coding   8.030679 2.076806 15.73992 0.3715389 0.4169759 2.915977 0.5954391 0.00000000 0.5120257 0.00000000 0.51202565 5.7060488 0.10413750 0.00000000 0.03153333 0.0315333333 1.000000e+00 8.059594e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102595 E001 2.0669306 0.0070157921 7.923668e-06 5.386713e-05 13 95801580 95801654 75 - 0.153 0.892 4.014
ENSG00000102595 E002 1.8884484 0.0081794326 4.688568e-04 2.041075e-03 13 95801655 95801680 26 - 0.193 0.799 3.237
ENSG00000102595 E003 25.4321217 0.0012591292 8.947945e-08 9.164025e-07 13 95801681 95801812 132 - 1.204 1.621 1.442
ENSG00000102595 E004 47.7772754 0.0044821059 5.310014e-07 4.673044e-06 13 95832927 95833053 127 - 1.499 1.832 1.132
ENSG00000102595 E005 45.0330956 0.0163791853 1.609960e-03 5.992890e-03 13 95837086 95837202 117 - 1.488 1.774 0.974
ENSG00000102595 E006 41.9169638 0.0189102280 7.756707e-04 3.171573e-03 13 95853543 95853657 115 - 1.450 1.763 1.065
ENSG00000102595 E007 43.0923843 0.0131096537 1.222252e-02 3.406628e-02 13 95854315 95854451 137 - 1.489 1.710 0.751
ENSG00000102595 E008 21.1331859 0.0059369047 8.735793e-01 9.227604e-01 13 95854452 95854475 24 - 1.234 1.264 0.108
ENSG00000102595 E009 41.7199798 0.0016393887 1.612398e-02 4.300917e-02 13 95856158 95856340 183 - 1.484 1.659 0.597
ENSG00000102595 E010 25.3408375 0.0123229720 1.354206e-01 2.416998e-01 13 95859591 95859675 85 - 1.278 1.439 0.558
ENSG00000102595 E011 2.1285456 0.0073959080 5.546023e-02 1.187756e-01 13 95859676 95859895 220 - 0.327 0.679 1.752
ENSG00000102595 E012 25.0308533 0.0020521502 8.576639e-01 9.121020e-01 13 95860788 95860883 96 - 1.300 1.330 0.107
ENSG00000102595 E013 1.1866387 0.0108938313 1.946379e-01 3.195433e-01 13 95863434 95863628 195 - 0.327 0.000 -11.638
ENSG00000102595 E014 29.1756931 0.0006907507 4.725058e-01 6.115611e-01 13 95863629 95863714 86 - 1.354 1.426 0.250
ENSG00000102595 E015 29.3889296 0.0008288422 9.023990e-02 1.754987e-01 13 95867339 95867423 85 - 1.338 1.484 0.506
ENSG00000102595 E016 0.2966881 0.0290785164 1.000000e+00   13 95876902 95877278 377 - 0.107 0.000 -9.638
ENSG00000102595 E017 25.5115876 0.0010075541 2.505149e-02 6.197996e-02 13 95877279 95877364 86 - 1.265 1.462 0.685
ENSG00000102595 E018 0.0000000       13 95877365 95877697 333 -      
ENSG00000102595 E019 37.0088517 0.0124324973 5.300226e-02 1.144900e-01 13 95877698 95877856 159 - 1.428 1.609 0.620
ENSG00000102595 E020 43.5027804 0.0006300885 5.719929e-01 6.981802e-01 13 95884491 95884680 190 - 1.527 1.580 0.180
ENSG00000102595 E021 1.4372262 0.0251409327 3.057683e-02 7.310033e-02 13 95887273 95887393 121 - 0.193 0.606 2.437
ENSG00000102595 E022 31.3394547 0.0023732102 8.769294e-01 9.249989e-01 13 95887892 95887971 80 - 1.400 1.401 0.004
ENSG00000102595 E023 31.1591704 0.0006863497 7.012215e-03 2.125509e-02 13 95890862 95890964 103 - 1.435 1.207 -0.796
ENSG00000102595 E024 28.8870970 0.0007067644 4.613484e-02 1.022853e-01 13 95894562 95894657 96 - 1.393 1.227 -0.580
ENSG00000102595 E025 32.8561493 0.0006562220 2.040859e-01 3.312861e-01 13 95895180 95895304 125 - 1.435 1.345 -0.310
ENSG00000102595 E026 25.8042210 0.0071439549 6.812894e-01 7.850224e-01 13 95900807 95900938 132 - 1.309 1.361 0.181
ENSG00000102595 E027 31.8527280 0.0007251763 1.949585e-01 3.199396e-01 13 95902854 95903060 207 - 1.424 1.330 -0.324
ENSG00000102595 E028 24.9022748 0.0008988970 9.347860e-02 1.805555e-01 13 95925680 95925774 95 - 1.332 1.186 -0.514
ENSG00000102595 E029 20.9429249 0.0142863110 7.307317e-02 1.484493e-01 13 95927028 95927126 99 - 1.268 1.062 -0.735
ENSG00000102595 E030 22.4518711 0.0010873951 8.357876e-03 2.468622e-02 13 95927213 95927336 124 - 1.303 1.034 -0.958
ENSG00000102595 E031 25.9762662 0.0008212812 1.018435e-01 1.933047e-01 13 95936924 95937088 165 - 1.346 1.207 -0.487
ENSG00000102595 E032 23.6092308 0.0009106861 2.640571e-01 4.020027e-01 13 95939957 95940091 135 - 1.300 1.207 -0.326
ENSG00000102595 E033 21.7379064 0.0026618688 6.411030e-02 1.335404e-01 13 95947037 95947172 136 - 1.274 1.091 -0.651
ENSG00000102595 E034 21.9701646 0.0488665402 7.698798e-02 1.546675e-01 13 95947996 95948081 86 - 1.287 1.042 -0.874
ENSG00000102595 E035 21.2737255 0.0011114064 8.905188e-03 2.604534e-02 13 95949335 95949454 120 - 1.278 1.003 -0.986
ENSG00000102595 E036 24.9826054 0.0007961631 5.068740e-06 3.602272e-05 13 95970112 95970262 151 - 1.367 0.848 -1.884
ENSG00000102595 E037 20.8653141 0.0033203500 5.405445e-02 1.163516e-01 13 95972580 95972671 92 - 1.261 1.064 -0.705
ENSG00000102595 E038 0.0000000       13 95983523 95983523 1 -      
ENSG00000102595 E039 0.4449813 0.0213266667 4.375697e-01 5.795200e-01 13 95983524 95983595 72 - 0.107 0.244 1.427
ENSG00000102595 E040 22.4219682 0.0078953407 2.248911e-01 3.562942e-01 13 95983804 95983864 61 - 1.281 1.164 -0.413
ENSG00000102595 E041 0.1451727 0.0428181303 1.000000e+00   13 95984904 95984909 6 - 0.057 0.000 -8.638
ENSG00000102595 E042 5.1970702 0.0811259083 7.180575e-01 8.132688e-01 13 95984910 95985046 137 - 0.681 0.747 0.274
ENSG00000102595 E043 10.2118313 0.0191497365 8.673354e-01 9.186846e-01 13 95985047 95985238 192 - 0.947 0.933 -0.052
ENSG00000102595 E044 12.1053679 0.0015061936 8.192755e-01 8.858826e-01 13 95985239 95985337 99 - 1.017 1.003 -0.052
ENSG00000102595 E045 47.6988164 0.0004602120 2.476760e-01 3.832120e-01 13 95986333 95986432 100 - 1.588 1.525 -0.216
ENSG00000102595 E046 0.2987644 0.0275412867 1.000000e+00   13 95989521 95989598 78 - 0.107 0.000 -9.639
ENSG00000102595 E047 49.1792768 0.0027800589 1.854725e-01 3.080953e-01 13 95989973 95990073 101 - 1.605 1.525 -0.274
ENSG00000102595 E048 7.9235878 0.0283833106 4.071603e-01 5.507697e-01 13 95990145 95991473 1329 - 0.872 0.744 -0.504
ENSG00000102595 E049 0.1472490 0.0441284300 1.000000e+00   13 95995911 95995914 4 - 0.057 0.000 -8.638
ENSG00000102595 E050 51.9241499 0.0038431716 5.448452e-01 6.752600e-01 13 95996063 95996135 73 - 1.616 1.589 -0.089
ENSG00000102595 E051 59.7680393 0.0004554596 1.531981e-01 2.660213e-01 13 95999211 95999307 97 - 1.685 1.613 -0.244
ENSG00000102595 E052 67.5596640 0.0003521284 1.614588e-02 4.305172e-02 13 96013307 96013481 175 - 1.747 1.621 -0.427
ENSG00000102595 E053 43.3667845 0.0015268876 2.005427e-02 5.160092e-02 13 96023040 96023152 113 - 1.564 1.401 -0.559
ENSG00000102595 E054 40.4117991 0.0005311871 7.916953e-03 2.357026e-02 13 96023629 96023759 131 - 1.538 1.345 -0.665
ENSG00000102595 E055 29.9256242 0.0011999363 1.277907e-01 2.310964e-01 13 96031889 96031971 83 - 1.400 1.282 -0.412
ENSG00000102595 E056 33.3054053 0.0123917208 6.711816e-02 1.385656e-01 13 96053155 96053482 328 - 1.450 1.284 -0.576