ENSG00000102580

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000602402 ENSG00000102580 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC3 protein_coding protein_coding 8.699416 2.970419 14.38871 0.1208832 0.4438685 2.272353 7.7911762 1.246198 14.1251069 0.08495415 0.3788494 3.492147 0.7656042 0.4230333 0.98196667 0.5589333 6.749802e-15 1.602363e-20 FALSE TRUE
MSTRG.8962.3 ENSG00000102580 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC3 protein_coding   8.699416 2.970419 14.38871 0.1208832 0.4438685 2.272353 0.8913582 1.724221 0.2317249 0.20434796 0.0830180 -2.842850 0.2331417 0.5769667 0.01586667 -0.5611000 1.602363e-20 1.602363e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102580 E001 3.6192368 0.0048556866 6.052153e-02 1.275120e-01 13 95677139 95677157 19 + 0.569 0.279 -1.590
ENSG00000102580 E002 45.6249224 0.0005214820 8.712422e-08 8.947483e-07 13 95677158 95677337 180 + 1.536 1.258 -0.963
ENSG00000102580 E003 59.1325883 0.0322687512 1.766606e-03 6.493183e-03 13 95709227 95709337 111 + 1.638 1.456 -0.622
ENSG00000102580 E004 66.1719805 0.0006252683 4.199118e-09 5.542853e-08 13 95723242 95723366 125 + 1.691 1.461 -0.784
ENSG00000102580 E005 51.3210649 0.0004350377 1.367062e-07 1.353042e-06 13 95725178 95725252 75 + 1.586 1.354 -0.799
ENSG00000102580 E006 0.5891098 0.0183197303 5.618988e-01 6.896174e-01 13 95740447 95740577 131 + 0.168 0.001 -8.004
ENSG00000102580 E007 69.0050621 0.0003817237 8.016868e-08 8.294313e-07 13 95757644 95757796 153 + 1.706 1.535 -0.582
ENSG00000102580 E008 84.5119681 0.0003696957 2.196880e-06 1.693422e-05 13 95760040 95760221 182 + 1.783 1.695 -0.298
ENSG00000102580 E009 66.3103030 0.0004134064 4.486790e-05 2.557033e-04 13 95760679 95760798 120 + 1.679 1.599 -0.273
ENSG00000102580 E010 56.7915157 0.0005317319 2.195233e-05 1.347985e-04 13 95763643 95763748 106 + 1.618 1.499 -0.406
ENSG00000102580 E011 76.1072477 0.0010032969 1.013792e-02 2.910261e-02 13 95763833 95763953 121 + 1.724 1.754 0.103
ENSG00000102580 E012 78.7310361 0.0018928187 1.489056e-02 4.024005e-02 13 95785939 95786071 133 + 1.737 1.774 0.125
ENSG00000102580 E013 65.7011273 0.0062603939 2.212457e-01 3.519285e-01 13 95787007 95787155 149 + 1.650 1.740 0.306
ENSG00000102580 E014 847.0561332 0.0075988947 1.304485e-17 6.314022e-16 13 95790873 95794988 4116 + 2.700 3.043 1.141