ENSG00000102572

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376547 ENSG00000102572 HEK293_OSMI2_2hA HEK293_TMG_2hB STK24 protein_coding protein_coding 49.64021 68.75763 43.9061 2.355956 1.566922 -0.6469796 43.185376 64.445343 33.859137 2.2025976 1.4748202 -0.92832870 0.85780417 0.93726667 0.77093333 -0.1663333 3.692812e-29 3.692812e-29 FALSE TRUE
ENST00000397517 ENSG00000102572 HEK293_OSMI2_2hA HEK293_TMG_2hB STK24 protein_coding protein_coding 49.64021 68.75763 43.9061 2.355956 1.566922 -0.6469796 3.324643 3.849397 4.091074 0.1749009 0.2774292 0.08762632 0.06885417 0.05593333 0.09373333 0.0378000 6.861232e-03 3.692812e-29 FALSE TRUE
ENST00000491878 ENSG00000102572 HEK293_OSMI2_2hA HEK293_TMG_2hB STK24 protein_coding processed_transcript 49.64021 68.75763 43.9061 2.355956 1.566922 -0.6469796 2.165158 0.000000 4.726304 0.0000000 0.9769627 8.88761786 0.05120833 0.00000000 0.10730000 0.1073000 1.328346e-25 3.692812e-29 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102572 E001 10.7817559 0.0015615765 5.866523e-02 1.243436e-01 13 98445185 98450198 5014 - 1.145 0.983 -0.592
ENSG00000102572 E002 0.0000000       13 98450199 98450200 2 -      
ENSG00000102572 E003 110.0400550 0.0010627609 2.123232e-01 3.412746e-01 13 98450201 98452158 1958 - 1.967 2.046 0.266
ENSG00000102572 E004 1827.8009404 0.0013647656 3.514516e-34 8.119689e-32 13 98452159 98453209 1051 - 3.071 3.300 0.760
ENSG00000102572 E005 7.8024606 0.0053062105 1.432821e-06 1.150624e-05 13 98455421 98455981 561 - 1.206 0.680 -1.992
ENSG00000102572 E006 8.2571801 0.0042100682 6.616094e-07 5.712589e-06 13 98455982 98456560 579 - 1.217 0.681 -2.028
ENSG00000102572 E007 6.0798683 0.0027575244 1.664520e-06 1.317092e-05 13 98456561 98457167 607 - 1.118 0.548 -2.262
ENSG00000102572 E008 442.1997431 0.0002078909 7.740072e-02 1.552964e-01 13 98457168 98457304 137 - 2.576 2.639 0.211
ENSG00000102572 E009 355.9566591 0.0010744812 8.457568e-01 9.040625e-01 13 98460372 98460440 69 - 2.509 2.535 0.085
ENSG00000102572 E010 586.7271848 0.0001448868 1.859825e-02 4.845003e-02 13 98461774 98461897 124 - 2.746 2.741 -0.019
ENSG00000102572 E011 671.3818618 0.0001358210 3.068298e-02 7.329859e-02 13 98463691 98463836 146 - 2.801 2.801 -0.001
ENSG00000102572 E012 677.8752629 0.0001317189 2.556826e-04 1.198909e-03 13 98466376 98466561 186 - 2.819 2.798 -0.071
ENSG00000102572 E013 331.3381948 0.0002029928 1.513815e-03 5.680652e-03 13 98474821 98474860 40 - 2.518 2.483 -0.116
ENSG00000102572 E014 464.9765537 0.0010316479 2.964699e-02 7.127581e-02 13 98474861 98474978 118 - 2.653 2.636 -0.055
ENSG00000102572 E015 421.9864034 0.0006499309 5.521466e-03 1.734245e-02 13 98475250 98475358 109 - 2.618 2.590 -0.090
ENSG00000102572 E016 262.2619414 0.0010611304 9.952166e-03 2.864230e-02 13 98482265 98482321 57 - 2.418 2.379 -0.128
ENSG00000102572 E017 0.8450104 0.0159622284 2.849459e-01 4.252438e-01 13 98505028 98505053 26 - 0.353 0.178 -1.309
ENSG00000102572 E018 0.4417591 0.1150794811 9.753473e-01 9.886390e-01 13 98508779 98508967 189 - 0.152 0.176 0.257
ENSG00000102572 E019 419.8547603 0.0012242077 4.841054e-18 2.456799e-16 13 98519243 98519473 231 - 2.703 2.532 -0.569
ENSG00000102572 E020 0.0000000       13 98521775 98521998 224 -      
ENSG00000102572 E021 0.3697384 0.0249281235 4.037026e-01 5.474802e-01 13 98575995 98576204 210 - 0.000 0.178 8.917
ENSG00000102572 E022 140.6836953 0.0024757521 7.074600e-30 1.180847e-27 13 98576745 98577151 407 - 2.346 1.946 -1.338
ENSG00000102572 E023 0.0000000       13 98577909 98577940 32 -