ENSG00000102531

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398316 ENSG00000102531 HEK293_OSMI2_2hA HEK293_TMG_2hB FNDC3A protein_coding protein_coding 10.0446 2.681085 15.35149 0.1990193 0.5261861 2.513058 5.971428 2.13020350 8.752597 0.17271164 0.8379027 2.033611 0.6527833 0.796733333 0.5677 -2.290333e-01 1.818735e-02 2.344365e-05 FALSE TRUE
ENST00000492622 ENSG00000102531 HEK293_OSMI2_2hA HEK293_TMG_2hB FNDC3A protein_coding protein_coding 10.0446 2.681085 15.35149 0.1990193 0.5261861 2.513058 2.229090 0.02304284 3.646310 0.02304284 0.6275565 6.789907 0.1676792 0.009966667 0.2402 2.302333e-01 2.344365e-05 2.344365e-05 FALSE TRUE
ENST00000541916 ENSG00000102531 HEK293_OSMI2_2hA HEK293_TMG_2hB FNDC3A protein_coding protein_coding 10.0446 2.681085 15.35149 0.1990193 0.5261861 2.513058 1.416337 0.39406029 2.235320 0.13634835 0.3151214 2.474278 0.1301500 0.145666667 0.1457 3.333333e-05 9.748192e-01 2.344365e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102531 E001 0.0000000       13 48974589 48974694 106 +      
ENSG00000102531 E002 0.0000000       13 48974695 48975065 371 +      
ENSG00000102531 E003 0.6674587 0.0302519840 5.395755e-01 6.708248e-01 13 48975066 48975294 229 + 0.130 0.281 1.379
ENSG00000102531 E004 1.4844702 0.2780086091 5.697634e-01 6.962836e-01 13 48975295 48975599 305 + 0.260 0.459 1.201
ENSG00000102531 E005 11.0960110 0.0209198126 1.359167e-05 8.753404e-05 13 48975912 48976068 157 + 0.989 0.000 -13.079
ENSG00000102531 E006 11.3271469 0.0015976845 6.983139e-04 2.893052e-03 13 48976069 48976177 109 + 0.984 0.450 -2.249
ENSG00000102531 E007 2.2018009 0.1625128374 9.166720e-01 9.513423e-01 13 48976609 48976672 64 + 0.379 0.456 0.412
ENSG00000102531 E008 10.7134663 0.0108956163 8.163971e-01 8.838244e-01 13 48976673 48976917 245 + 0.909 0.963 0.204
ENSG00000102531 E009 26.3203297 0.0007163070 4.307943e-04 1.892732e-03 13 49006152 49006289 138 + 1.309 1.003 -1.092
ENSG00000102531 E010 21.5957091 0.0045038902 2.281077e-02 5.734918e-02 13 49075289 49075364 76 + 1.218 1.041 -0.636
ENSG00000102531 E011 0.2944980 0.3736319921 1.000000e+00   13 49097548 49097634 87 + 0.091 0.000 -7.849
ENSG00000102531 E012 18.8336915 0.0222320503 3.313605e-01 4.749639e-01 13 49110313 49110406 94 + 1.148 1.106 -0.151
ENSG00000102531 E013 49.7193122 0.0004451866 3.502817e-06 2.583602e-05 13 49114655 49114731 77 + 1.574 1.282 -1.007
ENSG00000102531 E014 89.8524330 0.0011191383 7.563605e-12 1.605853e-10 13 49131137 49131374 238 + 1.829 1.465 -1.240
ENSG00000102531 E015 87.8777583 0.0004443425 1.502247e-15 5.552013e-14 13 49136332 49136601 270 + 1.825 1.358 -1.596
ENSG00000102531 E016 42.9762595 0.0006077030 1.549941e-06 1.234836e-05 13 49138747 49138805 59 + 1.516 1.165 -1.225
ENSG00000102531 E017 70.4087441 0.0008364714 1.363704e-05 8.779343e-05 13 49145778 49145935 158 + 1.714 1.516 -0.675
ENSG00000102531 E018 0.8889184 0.0135295324 8.507342e-01 9.074236e-01 13 49145936 49146847 912 + 0.200 0.280 0.638
ENSG00000102531 E019 45.4903623 0.0070529371 1.309712e-01 2.354915e-01 13 49167244 49167303 60 + 1.511 1.478 -0.115
ENSG00000102531 E020 65.6290614 0.0032317020 1.114649e-03 4.352700e-03 13 49168613 49168751 139 + 1.678 1.539 -0.473
ENSG00000102531 E021 40.8038963 0.0004897461 6.734761e-04 2.801670e-03 13 49172043 49172096 54 + 1.483 1.282 -0.695
ENSG00000102531 E022 64.9487374 0.0003909179 5.818198e-03 1.813357e-02 13 49174435 49174559 125 + 1.665 1.582 -0.281
ENSG00000102531 E023 75.0832844 0.0555162093 3.901722e-02 8.922857e-02 13 49175367 49175541 175 + 1.734 1.591 -0.484
ENSG00000102531 E024 58.3038711 0.0021447491 3.124701e-03 1.063232e-02 13 49178568 49178654 87 + 1.624 1.504 -0.410
ENSG00000102531 E025 68.8335805 0.0003760078 3.973608e-03 1.306765e-02 13 49185964 49186102 139 + 1.689 1.603 -0.292
ENSG00000102531 E026 60.4467434 0.0022486311 8.240750e-04 3.345450e-03 13 49187122 49187190 69 + 1.640 1.491 -0.509
ENSG00000102531 E027 71.2777546 0.0010808190 1.201081e-02 3.355718e-02 13 49188515 49188633 119 + 1.701 1.641 -0.205
ENSG00000102531 E028 49.0479945 0.0186315156 1.695164e-01 2.875648e-01 13 49191015 49191109 95 + 1.542 1.504 -0.127
ENSG00000102531 E029 23.9691386 0.0034917207 8.471527e-01 9.050695e-01 13 49191110 49191120 11 + 1.227 1.303 0.267
ENSG00000102531 E030 66.8401204 0.0023571956 2.397488e-02 5.975411e-02 13 49191209 49191384 176 + 1.675 1.622 -0.180
ENSG00000102531 E031 60.4623750 0.0005670345 2.970166e-02 7.137283e-02 13 49196877 49196990 114 + 1.630 1.583 -0.161
ENSG00000102531 E032 71.1818627 0.0006218157 7.840900e-01 8.614982e-01 13 49197725 49197874 150 + 1.682 1.765 0.280
ENSG00000102531 E033 93.6003836 0.0003879598 2.615895e-01 3.992423e-01 13 49197982 49198209 228 + 1.787 1.941 0.517
ENSG00000102531 E034 51.7817096 0.0004618746 4.767836e-01 6.153951e-01 13 49198210 49198265 56 + 1.539 1.683 0.491
ENSG00000102531 E035 99.1343014 0.0003048924 8.694875e-02 1.705124e-01 13 49198362 49198574 213 + 1.805 1.984 0.602
ENSG00000102531 E036 2.6334444 0.0061545821 7.929799e-01 8.676257e-01 13 49201133 49201229 97 + 0.439 0.450 0.055
ENSG00000102531 E037 89.8636196 0.0003666850 5.026133e-01 6.386651e-01 13 49201800 49201966 167 + 1.771 1.903 0.448
ENSG00000102531 E038 91.9499014 0.0003850606 6.459287e-02 1.343624e-01 13 49203157 49203284 128 + 1.771 1.959 0.634
ENSG00000102531 E039 523.1985265 0.0082071251 2.991729e-22 2.450386e-20 13 49207081 49209779 2699 + 2.460 2.905 1.479