ENSG00000102384

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403304 ENSG00000102384 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPI protein_coding protein_coding 8.338193 3.809877 12.65012 0.2587261 0.4026111 1.728693 0.8838757 0.0000000 2.4249720 0.00000000 0.36108756 7.9277613 0.07508333 0.00000000 0.19040000 0.19040000 1.838929e-12 1.838929e-12   FALSE
ENST00000423383 ENSG00000102384 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPI protein_coding protein_coding 8.338193 3.809877 12.65012 0.2587261 0.4026111 1.728693 1.0564694 0.3694259 1.4746119 0.22217045 0.54015242 1.9681957 0.12570833 0.08990000 0.11653333 0.02663333 8.375721e-01 1.838929e-12 FALSE TRUE
ENST00000682095 ENSG00000102384 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPI protein_coding protein_coding 8.338193 3.809877 12.65012 0.2587261 0.4026111 1.728693 1.5637537 0.8833096 2.4873750 0.48052020 1.28752827 1.4831802 0.16783333 0.24343333 0.19903333 -0.04440000 9.916517e-01 1.838929e-12 FALSE TRUE
ENST00000682304 ENSG00000102384 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPI protein_coding protein_coding 8.338193 3.809877 12.65012 0.2587261 0.4026111 1.728693 0.8029376 0.2344056 1.3643854 0.07814888 0.33219870 2.4914375 0.08945000 0.06370000 0.10690000 0.04320000 5.057675e-01 1.838929e-12   FALSE
ENST00000684367 ENSG00000102384 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPI protein_coding protein_coding 8.338193 3.809877 12.65012 0.2587261 0.4026111 1.728693 0.3483020 0.2797840 0.2507730 0.06333893 0.09311949 -0.1521834 0.04873333 0.07306667 0.02030000 -0.05276667 4.856019e-02 1.838929e-12 FALSE TRUE
MSTRG.34594.1 ENSG00000102384 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPI protein_coding   8.338193 3.809877 12.65012 0.2587261 0.4026111 1.728693 0.4631151 0.3393715 0.6460098 0.16998962 0.20974081 0.9089556 0.05566250 0.08996667 0.05023333 -0.03973333 9.032438e-01 1.838929e-12 FALSE TRUE
MSTRG.34594.4 ENSG00000102384 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPI protein_coding   8.338193 3.809877 12.65012 0.2587261 0.4026111 1.728693 1.9637118 0.4231881 3.1798024 0.24710454 0.77358372 2.8804016 0.24344167 0.10436667 0.25096667 0.14660000 2.648123e-01 1.838929e-12 FALSE TRUE
MSTRG.34594.5 ENSG00000102384 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPI protein_coding   8.338193 3.809877 12.65012 0.2587261 0.4026111 1.728693 0.7292423 0.8859038 0.1714706 0.17764283 0.12334954 -2.3036078 0.12667500 0.23930000 0.01423333 -0.22506667 3.626250e-03 1.838929e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102384 E001 1.8621497 0.0244411696 8.039507e-01 8.752411e-01 X 101098157 101098187 31 + 0.443 0.417 -0.137
ENSG00000102384 E002 1.8621497 0.0244411696 8.039507e-01 8.752411e-01 X 101098188 101098188 1 + 0.443 0.417 -0.137
ENSG00000102384 E003 3.0038482 0.1370364173 9.773610e-01 9.898909e-01 X 101098189 101098199 11 + 0.574 0.570 -0.016
ENSG00000102384 E004 8.5200808 0.0022866453 2.637855e-01 4.017022e-01 X 101098200 101098203 4 + 0.977 0.872 -0.396
ENSG00000102384 E005 15.8884745 0.0012626178 3.540890e-02 8.243959e-02 X 101098204 101098217 14 + 1.240 1.070 -0.608
ENSG00000102384 E006 21.4316738 0.0009112760 4.050595e-02 9.194853e-02 X 101098218 101098220 3 + 1.356 1.219 -0.478
ENSG00000102384 E007 24.6213540 0.0008168963 2.625814e-02 6.446859e-02 X 101098221 101098234 14 + 1.412 1.272 -0.488
ENSG00000102384 E008 19.1272595 0.0009468393 1.966164e-02 5.076371e-02 X 101098235 101098248 14 + 1.316 1.143 -0.614
ENSG00000102384 E009 6.1749952 0.0473161923 1.107324e-01 2.066096e-01 X 101098249 101098443 195 + 0.886 0.628 -1.043
ENSG00000102384 E010 45.7661224 0.0038209122 3.584143e-02 8.327877e-02 X 101098444 101098539 96 + 1.662 1.562 -0.342
ENSG00000102384 E011 3.0425192 0.2732757672 5.743045e-01 7.001416e-01 X 101098712 101098843 132 + 0.502 0.745 1.067
ENSG00000102384 E012 17.6863960 0.0010039567 3.046293e-01 4.466596e-01 X 101099809 101099930 122 + 1.198 1.319 0.426
ENSG00000102384 E013 15.2357038 0.0023270488 3.526512e-01 4.968964e-01 X 101099931 101100065 135 + 1.140 1.260 0.422
ENSG00000102384 E014 1.8078223 0.1006782151 1.003724e-01 1.910390e-01 X 101100437 101100700 264 + 0.298 0.668 1.891
ENSG00000102384 E015 90.8657455 0.0004179574 2.789905e-01 4.186880e-01 X 101101058 101101296 239 + 1.932 1.925 -0.024
ENSG00000102384 E016 49.3179772 0.0017710013 8.357196e-01 8.972620e-01 X 101102274 101102411 138 + 1.655 1.702 0.159
ENSG00000102384 E017 42.4379230 0.0006639679 6.562735e-01 7.659354e-01 X 101109473 101109591 119 + 1.600 1.610 0.032
ENSG00000102384 E018 45.1353171 0.0005335935 2.963040e-03 1.015355e-02 X 101109891 101109998 108 + 1.668 1.528 -0.476
ENSG00000102384 E019 35.2755414 0.0005935430 6.187947e-02 1.297798e-01 X 101120402 101120450 49 + 1.548 1.461 -0.297
ENSG00000102384 E020 33.3473402 0.0006245951 4.356091e-03 1.413729e-02 X 101120738 101120784 47 + 1.543 1.382 -0.555
ENSG00000102384 E021 30.9897720 0.0006367760 5.207793e-03 1.649668e-02 X 101126709 101126798 90 + 1.515 1.352 -0.564
ENSG00000102384 E022 41.6082871 0.0557316455 1.073082e-01 2.015628e-01 X 101127138 101127266 129 + 1.639 1.482 -0.537
ENSG00000102384 E023 60.1787154 0.0027688602 4.665491e-03 1.499904e-02 X 101127498 101127665 168 + 1.788 1.664 -0.421
ENSG00000102384 E024 53.2017578 0.0004713014 1.401793e-02 3.826757e-02 X 101128716 101128836 121 + 1.728 1.632 -0.325
ENSG00000102384 E025 50.6387596 0.0004578842 8.307687e-03 2.456357e-02 X 101129982 101130073 92 + 1.708 1.598 -0.374
ENSG00000102384 E026 58.6992458 0.0012972483 9.606318e-05 5.035662e-04 X 101132190 101132307 118 + 1.788 1.610 -0.603
ENSG00000102384 E027 45.9515455 0.0013882511 1.462350e-02 3.964728e-02 X 101132392 101132456 65 + 1.666 1.555 -0.378
ENSG00000102384 E028 43.6639281 0.0005384810 1.413031e-02 3.852050e-02 X 101140666 101140760 95 + 1.645 1.535 -0.375
ENSG00000102384 E029 0.8815316 0.0133010195 9.121481e-02 1.770294e-01 X 101140761 101141293 533 + 0.339 0.000 -10.529
ENSG00000102384 E030 42.9264303 0.0005590751 7.776434e-01 8.569155e-01 X 101145064 101145199 136 + 1.607 1.627 0.067
ENSG00000102384 E031 39.6472183 0.0114594461 6.476273e-01 7.592733e-01 X 101146153 101146277 125 + 1.555 1.629 0.251
ENSG00000102384 E032 33.2160317 0.0038103826 3.321704e-01 4.757881e-01 X 101147763 101147811 49 + 1.515 1.484 -0.109
ENSG00000102384 E033 66.3378077 0.0003716338 2.678632e-02 6.554622e-02 X 101147943 101148161 219 + 1.750 1.885 0.455
ENSG00000102384 E034 30.2886339 0.0007030476 1.828401e-01 3.047474e-01 X 101161528 101161569 42 + 1.419 1.542 0.422
ENSG00000102384 E035 443.2622111 0.0026876972 4.397408e-17 1.974113e-15 X 101162833 101166126 3294 + 2.530 2.759 0.763