ENSG00000102316

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000218439 ENSG00000102316 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED2 protein_coding protein_coding 145.9522 205.3751 132.7646 13.35519 1.797517 -0.6293517 12.99247 14.488104 12.13627 2.516531 0.6828303 -0.2553505 0.09288333 0.07043333 0.09146667 0.02103333 4.320100e-01 3.236808e-09 FALSE  
ENST00000375058 ENSG00000102316 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED2 protein_coding protein_coding 145.9522 205.3751 132.7646 13.35519 1.797517 -0.6293517 27.94922 46.058235 16.73124 2.423035 1.1959702 -1.4603659 0.19133333 0.22466667 0.12606667 -0.09860000 6.734785e-07 3.236808e-09 FALSE  
ENST00000375068 ENSG00000102316 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED2 protein_coding protein_coding 145.9522 205.3751 132.7646 13.35519 1.797517 -0.6293517 67.50689 91.965578 67.53016 6.146645 1.3661737 -0.4455052 0.45794583 0.44770000 0.50863333 0.06093333 9.447998e-04 3.236808e-09 FALSE  
MSTRG.34317.4 ENSG00000102316 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED2 protein_coding   145.9522 205.3751 132.7646 13.35519 1.797517 -0.6293517 5.36551 5.221079 10.08092 2.109522 0.3849570 0.9478781 0.03766667 0.02500000 0.07603333 0.05103333 1.425476e-02 3.236808e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102316 E001 0.1472490 4.376850e-02 2.797468e-01   X 54807598 54807598 1 + 0.155 0.000 -11.702
ENSG00000102316 E002 3.1364961 6.244923e-03 3.086191e-01 4.508973e-01 X 54807599 54807707 109 + 0.687 0.540 -0.651
ENSG00000102316 E003 4.0180277 5.241448e-03 1.599353e-02 4.271834e-02 X 54807708 54807712 5 + 0.872 0.540 -1.388
ENSG00000102316 E004 43.3812704 4.758901e-04 2.239086e-17 1.043000e-15 X 54807713 54807744 32 + 1.865 1.429 -1.482
ENSG00000102316 E005 45.8684082 4.621580e-04 8.259786e-19 4.611823e-17 X 54807745 54807746 2 + 1.892 1.449 -1.506
ENSG00000102316 E006 62.7417173 3.923584e-04 3.254880e-18 1.682476e-16 X 54807747 54807754 8 + 1.992 1.617 -1.266
ENSG00000102316 E007 482.5586895 1.208617e-04 6.837240e-66 8.693252e-63 X 54807755 54807802 48 + 2.824 2.551 -0.908
ENSG00000102316 E008 0.2214452 4.925341e-02 8.170438e-01   X 54808338 54808341 4 + 0.000 0.096 9.874
ENSG00000102316 E009 0.4428904 6.464130e-01 5.688204e-01 6.954365e-01 X 54808342 54808343 2 + 0.000 0.184 10.968
ENSG00000102316 E010 63.1826760 4.044719e-04 3.040001e-01 4.459787e-01 X 54808344 54808370 27 + 1.738 1.800 0.208
ENSG00000102316 E011 306.8594662 3.617922e-03 7.683703e-01 8.503292e-01 X 54808371 54808433 63 + 2.462 2.459 -0.011
ENSG00000102316 E012 3.0163392 1.012024e-02 2.845573e-01 4.248011e-01 X 54809060 54809096 37 + 0.435 0.624 0.900
ENSG00000102316 E013 7.0843506 2.584205e-03 4.580257e-01 5.983464e-01 X 54809097 54809109 13 + 0.819 0.923 0.401
ENSG00000102316 E014 37.7336767 5.833987e-04 7.843081e-03 2.338813e-02 X 54809110 54809223 114 + 1.435 1.614 0.614
ENSG00000102316 E015 44.0476152 2.092336e-03 1.283115e-02 3.551862e-02 X 54809224 54809302 79 + 1.510 1.675 0.560
ENSG00000102316 E016 1125.5134691 8.435321e-04 1.616940e-13 4.466674e-12 X 54809303 54809376 74 + 3.100 2.982 -0.394
ENSG00000102316 E017 1253.5393133 5.933710e-04 8.163442e-13 2.033583e-11 X 54809722 54809808 87 + 3.135 3.036 -0.330
ENSG00000102316 E018 599.7150841 1.845490e-03 6.379562e-02 1.330166e-01 X 54809809 54809817 9 + 2.777 2.737 -0.131
ENSG00000102316 E019 726.1006665 2.758160e-03 2.828453e-01 4.229083e-01 X 54809818 54809871 54 + 2.849 2.825 -0.081
ENSG00000102316 E020 685.7816267 2.309359e-03 6.874734e-01 7.898154e-01 X 54809872 54809922 51 + 2.811 2.807 -0.012
ENSG00000102316 E021 1671.4800070 2.583331e-03 2.768534e-01 4.163350e-01 X 54809923 54810117 195 + 3.209 3.187 -0.070
ENSG00000102316 E022 1130.5654568 1.423315e-03 8.106456e-01 8.798706e-01 X 54810118 54810213 96 + 3.016 3.030 0.047
ENSG00000102316 E023 1082.7195234 5.004372e-04 4.732093e-01 6.122122e-01 X 54810821 54810904 84 + 2.993 3.016 0.075
ENSG00000102316 E024 1170.2127817 7.603564e-05 9.092035e-03 2.651160e-02 X 54810905 54811045 141 + 3.013 3.056 0.141
ENSG00000102316 E025 1080.2576536 1.002680e-04 6.421615e-01 7.550150e-01 X 54811046 54811129 84 + 2.995 3.013 0.060
ENSG00000102316 E026 3.9974168 3.980048e-03 1.282499e-03 4.918531e-03 X 54811130 54811130 1 + 0.920 0.473 -1.891
ENSG00000102316 E027 949.6666115 1.293265e-03 2.403888e-01 3.745943e-01 X 54811250 54811313 64 + 2.960 2.946 -0.048
ENSG00000102316 E028 7.7502312 2.615616e-03 2.318702e-04 1.099415e-03 X 54811532 54811573 42 + 1.143 0.735 -1.540
ENSG00000102316 E029 1009.8820453 2.441552e-04 4.084479e-01 5.520543e-01 X 54811574 54811653 80 + 2.978 2.979 0.002
ENSG00000102316 E030 661.3475437 1.441780e-04 8.662844e-01 9.178998e-01 X 54812157 54812172 16 + 2.786 2.802 0.052
ENSG00000102316 E031 1117.8569791 1.437153e-04 4.995434e-01 6.358645e-01 X 54812173 54812251 79 + 3.020 3.025 0.014
ENSG00000102316 E032 1069.1254909 8.894786e-05 1.056492e-01 1.990862e-01 X 54812945 54813024 80 + 2.982 3.014 0.106
ENSG00000102316 E033 930.0938083 1.038420e-03 1.880069e-02 4.889670e-02 X 54813118 54813160 43 + 2.902 2.958 0.185
ENSG00000102316 E034 27.5533753 1.093345e-03 1.666720e-09 2.369644e-08 X 54813161 54813334 174 + 1.652 1.267 -1.327
ENSG00000102316 E035 1119.5695739 1.295628e-03 1.233767e-01 2.247688e-01 X 54813488 54813550 63 + 2.993 3.034 0.137
ENSG00000102316 E036 1486.2113738 1.252670e-03 2.308443e-04 1.095181e-03 X 54814661 54814775 115 + 3.088 3.168 0.265
ENSG00000102316 E037 2701.5907029 9.241182e-04 2.912910e-15 1.038859e-13 X 54815248 54815690 443 + 3.311 3.441 0.432
ENSG00000102316 E038 136.2997454 4.953276e-04 2.947021e-11 5.683066e-10 X 54815691 54815880 190 + 1.931 2.181 0.839
ENSG00000102316 E039 561.0344578 3.808398e-03 7.616138e-06 5.198352e-05 X 54815881 54816015 135 + 2.602 2.770 0.558