ENSG00000102309

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373669 ENSG00000102309 HEK293_OSMI2_2hA HEK293_TMG_2hB PIN4 protein_coding protein_coding 152.5375 193.6032 151.691 12.43073 2.635032 -0.3519468 28.25311 34.52675 27.13200 2.817668 0.7769092 -0.3476053 0.1845917 0.1779667 0.1791333 0.001166667 1.0000000000 0.0001511394 FALSE FALSE
MSTRG.34453.10 ENSG00000102309 HEK293_OSMI2_2hA HEK293_TMG_2hB PIN4 protein_coding   152.5375 193.6032 151.691 12.43073 2.635032 -0.3519468 92.81061 135.36024 84.74907 10.597590 4.7028166 -0.6754709 0.6059208 0.6979333 0.5580000 -0.139933333 0.0001511394 0.0001511394 FALSE FALSE
MSTRG.34453.6 ENSG00000102309 HEK293_OSMI2_2hA HEK293_TMG_2hB PIN4 protein_coding   152.5375 193.6032 151.691 12.43073 2.635032 -0.3519468 25.86190 18.03643 33.42104 1.954133 1.7202333 0.8894745 0.1720292 0.0951000 0.2205667 0.125466667 0.0007130370 0.0001511394 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102309 E001 0.0000000       X 72181142 72181167 26 +      
ENSG00000102309 E002 2.0315579 7.877141e-03 9.507270e-01 9.731596e-01 X 72181308 72181332 25 + 0.471 0.461 -0.051
ENSG00000102309 E003 2.9182837 5.419706e-03 6.488763e-01 7.602770e-01 X 72181333 72181352 20 + 0.525 0.599 0.338
ENSG00000102309 E004 3.3933522 4.692914e-03 1.462273e-01 2.565552e-01 X 72181353 72181416 64 + 0.471 0.703 1.047
ENSG00000102309 E005 1.8477626 1.161196e-01 5.108677e-01 6.460211e-01 X 72181417 72181648 232 + 0.338 0.468 0.718
ENSG00000102309 E006 2.3636187 6.497983e-03 7.053876e-01 8.037626e-01 X 72181649 72181675 27 + 0.471 0.535 0.311
ENSG00000102309 E007 19.0268717 2.048361e-03 1.406643e-01 2.489298e-01 X 72181676 72181756 81 + 1.353 1.236 -0.411
ENSG00000102309 E008 21.3790354 1.937068e-02 5.455128e-01 6.758335e-01 X 72181757 72181764 8 + 1.368 1.303 -0.226
ENSG00000102309 E009 513.2397519 1.663320e-04 1.249564e-14 4.054919e-13 X 72181765 72181793 29 + 2.770 2.649 -0.401
ENSG00000102309 E010 780.1898241 1.125001e-04 8.403014e-01 9.002875e-01 X 72181794 72181828 35 + 2.881 2.879 -0.006
ENSG00000102309 E011 2.6893368 3.083722e-02 4.725918e-01 6.116473e-01 X 72181829 72181925 97 + 0.471 0.598 0.599
ENSG00000102309 E012 0.2214452 4.546899e-02 6.669768e-01   X 72185442 72185531 90 + 0.000 0.104 9.875
ENSG00000102309 E013 5.5318430 1.008745e-01 6.557371e-01 7.655695e-01 X 72186234 72186460 227 + 0.863 0.764 -0.390
ENSG00000102309 E014 1082.9431824 8.555535e-05 2.552847e-01 3.921360e-01 X 72186461 72186534 74 + 3.014 3.027 0.042
ENSG00000102309 E015 1277.1344999 1.290629e-04 1.916060e-05 1.193738e-04 X 72196785 72196904 120 + 3.068 3.109 0.138
ENSG00000102309 E016 16.4963860 2.764220e-03 5.734072e-01 6.993351e-01 X 72196905 72197367 463 + 1.261 1.214 -0.166
ENSG00000102309 E017 778.6472077 4.853266e-04 5.673482e-02 1.210074e-01 X 72197368 72198343 976 + 2.861 2.889 0.094
ENSG00000102309 E018 0.3289534 2.987529e-02 7.872590e-01   X 72203700 72203740 41 + 0.144 0.104 -0.537
ENSG00000102309 E019 2.9335005 3.377874e-01 4.982519e-01 6.347325e-01 X 72239942 72239990 49 + 0.724 0.490 -1.040
ENSG00000102309 E020 4.9494255 7.231164e-02 4.255886e-01 5.685288e-01 X 72241399 72241488 90 + 0.656 0.831 0.711
ENSG00000102309 E021 69.9470113 6.757704e-03 5.519566e-05 3.076753e-04 X 72262707 72264311 1605 + 1.967 1.737 -0.777
ENSG00000102309 E022 0.6717251 2.822205e-02 1.746018e-01 2.941771e-01 X 72298982 72299073 92 + 0.338 0.104 -2.120
ENSG00000102309 E023 0.3030308 3.827059e-01 1.977884e-01   X 72301532 72301652 121 + 0.252 0.000 -11.769
ENSG00000102309 E024 0.0000000       X 72302821 72302926 106 +