ENSG00000102241

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000218364 ENSG00000102241 HEK293_OSMI2_2hA HEK293_TMG_2hB HTATSF1 protein_coding protein_coding 85.73475 77.41167 100.4177 5.066854 3.349786 0.3753483 68.46968 69.262263 71.29272 3.824874 2.5439322 0.04167926 0.80449167 0.89630000 0.7098667 -0.1864333 9.964002e-06 2.80923e-84 FALSE TRUE
ENST00000448450 ENSG00000102241 HEK293_OSMI2_2hA HEK293_TMG_2hB HTATSF1 protein_coding protein_coding 85.73475 77.41167 100.4177 5.066854 3.349786 0.3753483 4.29961 0.000000 11.81864 0.000000 0.5836055 10.20806904 0.04363333 0.00000000 0.1176000 0.1176000 2.809230e-84 2.80923e-84 FALSE TRUE
MSTRG.34957.2 ENSG00000102241 HEK293_OSMI2_2hA HEK293_TMG_2hB HTATSF1 protein_coding   85.73475 77.41167 100.4177 5.066854 3.349786 0.3753483 10.34087 4.566396 15.87698 1.074359 0.9895340 1.79556106 0.11841250 0.05766667 0.1578333 0.1001667 2.606945e-04 2.80923e-84 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102241 E001 1.5812555 5.264614e-02 1.130599e-01 2.099970e-01 X 136497079 136497220 142 + 0.512 0.245 -1.572
ENSG00000102241 E002 3.8146814 2.026061e-02 4.747743e-02 1.046914e-01 X 136497221 136497227 7 + 0.783 0.514 -1.161
ENSG00000102241 E003 6.3141139 2.910349e-03 2.386615e-03 8.419214e-03 X 136497228 136497232 5 + 0.988 0.643 -1.362
ENSG00000102241 E004 8.7143555 1.977236e-03 1.963713e-03 7.112368e-03 X 136497233 136497233 1 + 1.098 0.798 -1.129
ENSG00000102241 E005 9.1498735 1.861350e-03 6.920881e-04 2.870335e-03 X 136497234 136497237 4 + 1.126 0.798 -1.230
ENSG00000102241 E006 113.6485668 1.525895e-02 1.107208e-11 2.289926e-10 X 136497238 136497439 202 + 2.208 1.789 -1.404
ENSG00000102241 E007 0.5911862 1.851918e-02 5.280776e-02 1.141506e-01 X 136497440 136497485 46 + 0.327 0.000 -10.008
ENSG00000102241 E008 52.9358546 9.067071e-04 3.040609e-08 3.419210e-07 X 136497592 136497623 32 + 1.821 1.596 -0.764
ENSG00000102241 E009 93.8903266 2.908366e-03 1.081274e-10 1.898111e-09 X 136497624 136497629 6 + 2.071 1.834 -0.796
ENSG00000102241 E010 149.5475115 2.380682e-03 2.720540e-17 1.254926e-15 X 136497630 136497675 46 + 2.279 2.014 -0.885
ENSG00000102241 E011 493.3361956 6.281844e-04 2.601065e-34 6.091026e-32 X 136497676 136497870 195 + 2.768 2.585 -0.610
ENSG00000102241 E012 617.0038430 1.505461e-04 1.516327e-29 2.438571e-27 X 136499598 136499778 181 + 2.838 2.726 -0.371
ENSG00000102241 E013 366.0149791 2.475935e-04 8.453048e-12 1.781912e-10 X 136500158 136500205 48 + 2.597 2.520 -0.255
ENSG00000102241 E014 659.8319890 3.236447e-04 2.918890e-10 4.759639e-09 X 136500664 136500818 155 + 2.836 2.795 -0.136
ENSG00000102241 E015 733.9121977 1.675414e-04 2.080748e-10 3.474890e-09 X 136502778 136502941 164 + 2.876 2.846 -0.100
ENSG00000102241 E016 562.2074821 4.788636e-04 1.492466e-04 7.437869e-04 X 136504364 136504463 100 + 2.750 2.742 -0.027
ENSG00000102241 E017 480.8042352 2.032780e-03 9.418326e-01 9.674302e-01 X 136509091 136509180 90 + 2.649 2.710 0.203
ENSG00000102241 E018 635.9322395 6.750329e-04 3.934701e-01 5.373654e-01 X 136510082 136510219 138 + 2.778 2.822 0.148
ENSG00000102241 E019 1100.3418298 9.746674e-05 3.863031e-02 8.850400e-02 X 136510808 136511126 319 + 2.997 3.078 0.269
ENSG00000102241 E020 504.3144785 1.102712e-04 4.876600e-06 3.481131e-05 X 136511127 136511207 81 + 2.632 2.763 0.437
ENSG00000102241 E021 3106.3803882 1.943320e-03 7.958652e-28 1.110267e-25 X 136511208 136512346 1139 + 3.362 3.600 0.792