ENSG00000102226

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377107 ENSG00000102226 HEK293_OSMI2_2hA HEK293_TMG_2hB USP11 protein_coding protein_coding 109.3524 148.2094 95.00485 8.268539 0.4015364 -0.6415098 77.73918 121.89463 62.93896 4.519653 0.2009474 -0.9534985 0.687725 0.82433333 0.6625 -0.16183333 0.0001006957 6.668332e-16 FALSE TRUE
MSTRG.34168.6 ENSG00000102226 HEK293_OSMI2_2hA HEK293_TMG_2hB USP11 protein_coding   109.3524 148.2094 95.00485 8.268539 0.4015364 -0.6415098 12.28862 9.09165 14.61075 3.432613 0.3301450 0.6838178 0.123300 0.05906667 0.1538 0.09473333 0.0901951523 6.668332e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102226 E001 2.251859 1.019546e-02 5.251961e-01 6.586044e-01 X 47232866 47232983 118 + 0.567 0.460 -0.514
ENSG00000102226 E002 6.970777 2.449489e-03 5.548942e-01 6.838158e-01 X 47232984 47233008 25 + 0.913 0.839 -0.283
ENSG00000102226 E003 41.435549 1.162208e-03 1.411257e-02 3.848267e-02 X 47233009 47233029 21 + 1.678 1.536 -0.486
ENSG00000102226 E004 570.291725 9.943941e-04 4.322826e-08 4.723147e-07 X 47233030 47233219 190 + 2.797 2.679 -0.391
ENSG00000102226 E005 2.575615 9.291305e-03 2.146771e-01 3.440626e-01 X 47233220 47233258 39 + 0.662 0.460 -0.928
ENSG00000102226 E006 2.988191 8.599127e-02 7.130396e-02 1.454885e-01 X 47233392 47233429 38 + 0.773 0.427 -1.559
ENSG00000102226 E007 3.869733 1.901349e-02 4.554246e-02 1.011914e-01 X 47233430 47233433 4 + 0.835 0.528 -1.298
ENSG00000102226 E008 26.661471 1.584737e-02 8.537188e-03 2.513200e-02 X 47233434 47233533 100 + 1.550 1.314 -0.816
ENSG00000102226 E009 6.120369 2.692624e-03 6.766131e-01 7.815483e-01 X 47233772 47233912 141 + 0.862 0.808 -0.212
ENSG00000102226 E010 636.474637 1.390761e-03 5.629720e-04 2.395682e-03 X 47239070 47239179 110 + 2.820 2.741 -0.263
ENSG00000102226 E011 748.548683 6.271878e-04 3.150085e-06 2.345073e-05 X 47239351 47239481 131 + 2.893 2.809 -0.277
ENSG00000102226 E012 3.689075 5.153201e-03 7.957654e-04 3.244563e-03 X 47239482 47239789 308 + 0.913 0.424 -2.119
ENSG00000102226 E013 782.447433 1.543409e-03 3.904537e-06 2.846105e-05 X 47239790 47239907 118 + 2.926 2.822 -0.346
ENSG00000102226 E014 797.955144 2.194823e-03 1.911661e-06 1.493314e-05 X 47240305 47240401 97 + 2.945 2.824 -0.402
ENSG00000102226 E015 659.721348 7.180165e-04 2.295301e-11 4.508428e-10 X 47240402 47240450 49 + 2.866 2.738 -0.423
ENSG00000102226 E016 724.980866 4.759641e-04 5.318297e-12 1.157422e-10 X 47240587 47240648 62 + 2.901 2.784 -0.390
ENSG00000102226 E017 945.813988 9.277721e-04 8.098777e-07 6.858690e-06 X 47240774 47240876 103 + 3.000 2.909 -0.305
ENSG00000102226 E018 22.024921 1.972829e-03 5.269358e-14 1.558813e-12 X 47240877 47241178 302 + 1.631 1.066 -1.973
ENSG00000102226 E019 1174.192560 1.114557e-04 5.362511e-06 3.790291e-05 X 47241277 47241450 174 + 3.068 3.015 -0.179
ENSG00000102226 E020 9.726646 2.524217e-02 5.165388e-06 3.664360e-05 X 47241454 47241540 87 + 1.298 0.724 -2.136
ENSG00000102226 E021 398.752613 8.379513e-04 4.558572e-01 5.963484e-01 X 47241541 47241546 6 + 2.575 2.558 -0.058
ENSG00000102226 E022 1042.125069 1.149056e-04 3.186047e-01 4.615673e-01 X 47241547 47241699 153 + 2.989 2.975 -0.044
ENSG00000102226 E023 441.564676 3.117668e-04 9.360382e-01 9.637846e-01 X 47242082 47242084 3 + 2.607 2.605 -0.008
ENSG00000102226 E024 737.474998 2.924351e-04 1.254392e-01 2.277759e-01 X 47242085 47242155 71 + 2.846 2.822 -0.082
ENSG00000102226 E025 951.194534 7.867926e-04 2.761116e-01 4.155195e-01 X 47242156 47242306 151 + 2.954 2.935 -0.063
ENSG00000102226 E026 3.764329 4.346788e-03 1.140915e-02 3.213877e-02 X 47242307 47242438 132 + 0.862 0.495 -1.564
ENSG00000102226 E027 740.002365 8.720647e-04 3.682166e-01 5.126214e-01 X 47242439 47242522 84 + 2.819 2.837 0.061
ENSG00000102226 E028 722.959951 1.173671e-04 6.294890e-03 1.938693e-02 X 47242626 47242720 95 + 2.793 2.833 0.133
ENSG00000102226 E029 1302.220584 1.515947e-04 1.635082e-01 2.797176e-01 X 47243396 47243602 207 + 3.066 3.081 0.053
ENSG00000102226 E030 661.754218 2.292731e-04 3.795016e-01 5.237710e-01 X 47244498 47244512 15 + 2.794 2.779 -0.049
ENSG00000102226 E031 777.897894 6.339158e-04 6.888730e-01 7.909054e-01 X 47244513 47244550 38 + 2.859 2.853 -0.023
ENSG00000102226 E032 546.381223 2.018304e-04 3.730328e-01 5.174705e-01 X 47244682 47244684 3 + 2.712 2.696 -0.053
ENSG00000102226 E033 1774.353121 2.516003e-04 1.004828e-03 3.975141e-03 X 47244685 47244924 240 + 3.184 3.222 0.126
ENSG00000102226 E034 3.880267 4.671756e-03 2.604317e-01 3.979610e-01 X 47244925 47245015 91 + 0.774 0.609 -0.688
ENSG00000102226 E035 943.508763 2.500955e-04 1.467396e-04 7.330673e-04 X 47245016 47245086 71 + 2.897 2.952 0.181
ENSG00000102226 E036 5.056492 1.409685e-01 8.619352e-01 9.149906e-01 X 47245087 47245325 239 + 0.774 0.730 -0.178
ENSG00000102226 E037 1086.638933 9.091752e-05 1.732268e-15 6.352554e-14 X 47245370 47245482 113 + 2.927 3.025 0.326
ENSG00000102226 E038 509.061110 1.398082e-04 3.985002e-16 1.586689e-14 X 47247072 47247081 10 + 2.560 2.708 0.492
ENSG00000102226 E039 1243.849724 4.320517e-04 4.148288e-14 1.245058e-12 X 47247082 47247221 140 + 2.977 3.088 0.370
ENSG00000102226 E040 28.943707 6.614056e-04 1.918687e-15 6.991528e-14 X 47247222 47247303 82 + 1.728 1.219 -1.754
ENSG00000102226 E041 1188.106763 4.217748e-04 7.814299e-07 6.642715e-06 X 47247304 47247419 116 + 2.985 3.058 0.242
ENSG00000102226 E042 53.241035 8.639335e-03 3.490708e-11 6.647608e-10 X 47247420 47247610 191 + 1.947 1.513 -1.471
ENSG00000102226 E043 984.916913 9.192070e-04 1.733771e-07 1.682587e-06 X 47247611 47247699 89 + 2.884 2.984 0.334
ENSG00000102226 E044 1445.768951 1.832551e-03 5.036709e-13 1.295925e-11 X 47247793 47248328 536 + 3.001 3.168 0.554