ENSG00000102195

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000218316 ENSG00000102195 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR50 protein_coding protein_coding 5.009809 5.637537 3.543937 0.3517127 0.3202335 -0.6682036 4.0624901 4.6262200 2.5382461 0.17019857 0.1272517 -0.8634444 0.8104583 0.8235000 0.7223333 -0.1011667 0.31698399 0.03410952 FALSE TRUE
MSTRG.35043.2 ENSG00000102195 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR50 protein_coding   5.009809 5.637537 3.543937 0.3517127 0.3202335 -0.6682036 0.7483489 0.7250427 0.9367824 0.04827266 0.2266292 0.3652049 0.1537167 0.1285333 0.2577667 0.1292333 0.03410952 0.03410952 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102195 E001 0.2214452 0.0378750605 0.8099064177   X 151176584 151176592 9 + 0.001 0.096 7.486
ENSG00000102195 E002 4.1182864 0.0096155322 0.1263666451 0.2290825974 X 151176593 151176604 12 + 0.818 0.598 -0.913
ENSG00000102195 E003 24.4611577 0.0157093138 0.2349157017 0.3682557442 X 151176605 151176780 176 + 1.441 1.339 -0.353
ENSG00000102195 E004 31.0339953 0.0125881338 0.2517080675 0.3879790269 X 151176781 151176908 128 + 1.532 1.444 -0.304
ENSG00000102195 E005 57.8480732 0.0004101853 0.0063075355 0.0194214870 X 151179771 151180092 322 + 1.815 1.696 -0.405
ENSG00000102195 E006 35.9384302 0.0016349912 0.1568598550 0.2709220688 X 151180093 151180207 115 + 1.593 1.510 -0.286
ENSG00000102195 E007 27.3998725 0.0008231814 0.9812644377 0.9923165414 X 151180208 151180279 72 + 1.427 1.426 -0.006
ENSG00000102195 E008 22.3740821 0.0008604169 0.4410468491 0.5826911846 X 151180280 151180325 46 + 1.299 1.356 0.201
ENSG00000102195 E009 28.3122675 0.0007560407 0.5852536345 0.7089814953 X 151180326 151180418 93 + 1.413 1.449 0.125
ENSG00000102195 E010 34.5377773 0.0006164436 0.7496061494 0.8365130397 X 151180419 151180554 136 + 1.504 1.523 0.065
ENSG00000102195 E011 139.2727211 0.0012961691 0.0001956303 0.0009452072 X 151180555 151181465 911 + 2.038 2.147 0.364