ENSG00000102189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322349 ENSG00000102189 HEK293_OSMI2_2hA HEK293_TMG_2hB EEA1 protein_coding protein_coding 3.35635 0.4782335 5.238686 0.03270847 0.1385479 3.426313 2.4782184 0.4502662 4.020886 0.02612987 0.1296527 3.130557 0.8545083 0.9462333 0.7675000 -0.1787333 0.052407763 0.002625247 FALSE TRUE
ENST00000418984 ENSG00000102189 HEK293_OSMI2_2hA HEK293_TMG_2hB EEA1 protein_coding nonsense_mediated_decay 3.35635 0.4782335 5.238686 0.03270847 0.1385479 3.426313 0.6674874 0.0000000 1.007201 0.00000000 0.1453687 6.668461 0.1058792 0.0000000 0.1911667 0.1911667 0.002625247 0.002625247 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102189 E001 222.1789473 0.0067132717 3.827472e-36 1.007088e-33 12 92770637 92776133 5497 - 1.996 2.556 1.871
ENSG00000102189 E002 25.6137073 0.0007755391 4.461987e-01 5.876943e-01 12 92776844 92776942 99 - 1.163 1.166 0.013
ENSG00000102189 E003 28.3904585 0.0031678810 7.799222e-01 8.585250e-01 12 92777543 92777663 121 - 1.199 1.265 0.232
ENSG00000102189 E004 44.9386527 0.0005304813 2.714384e-01 4.101995e-01 12 92777941 92778179 239 - 1.396 1.391 -0.015
ENSG00000102189 E005 36.3028404 0.0006010714 1.733526e-01 2.925608e-01 12 92779115 92779300 186 - 1.312 1.265 -0.166
ENSG00000102189 E006 27.6692126 0.0175965704 9.104126e-01 9.470348e-01 12 92780280 92780411 132 - 1.189 1.266 0.271
ENSG00000102189 E007 27.0788738 0.0007274590 2.005783e-01 3.269318e-01 12 92781950 92782135 186 - 1.190 1.128 -0.221
ENSG00000102189 E008 29.4487015 0.0006881278 1.916577e-01 3.158373e-01 12 92787867 92788049 183 - 1.224 1.166 -0.206
ENSG00000102189 E009 31.8276057 0.0056628317 5.332446e-03 1.683581e-02 12 92798892 92799086 195 - 1.270 0.987 -1.019
ENSG00000102189 E010 25.4537649 0.0007486293 5.083992e-03 1.615883e-02 12 92801600 92801701 102 - 1.180 0.858 -1.187
ENSG00000102189 E011 41.4108670 0.0005821085 2.434919e-01 3.782818e-01 12 92802404 92802664 261 - 1.361 1.345 -0.057
ENSG00000102189 E012 19.5107944 0.0043375355 1.323676e-01 2.373895e-01 12 92802665 92802734 70 - 1.063 0.927 -0.503
ENSG00000102189 E013 25.4664102 0.0011082268 8.775618e-02 1.717278e-01 12 92809017 92809156 140 - 1.170 1.039 -0.473
ENSG00000102189 E014 22.4004279 0.0008269117 4.874110e-02 1.069298e-01 12 92811279 92811434 156 - 1.120 0.927 -0.708
ENSG00000102189 E015 9.7140599 0.0056007094 5.967672e-01 7.186539e-01 12 92812980 92813003 24 - 0.786 0.777 -0.039
ENSG00000102189 E016 14.9242350 0.0030638603 9.248215e-03 2.690489e-02 12 92813004 92813093 90 - 0.971 0.542 -1.748
ENSG00000102189 E017 26.0356121 0.0007179139 3.271302e-02 7.722597e-02 12 92816200 92816400 201 - 1.183 0.987 -0.710
ENSG00000102189 E018 22.8061740 0.0008915471 9.452027e-02 1.821626e-01 12 92819308 92819511 204 - 1.126 0.987 -0.506
ENSG00000102189 E019 0.4396707 0.0336417076 1.000000e+00 1.000000e+00 12 92821053 92821099 47 - 0.099 0.000 -8.746
ENSG00000102189 E020 18.9026819 0.0080849958 2.874355e-02 6.949006e-02 12 92826166 92826285 120 - 1.057 0.777 -1.064
ENSG00000102189 E021 23.0105431 0.0008225545 1.393401e-02 3.807291e-02 12 92827912 92828061 150 - 1.137 0.858 -1.031
ENSG00000102189 E022 42.4097798 0.0006897908 2.022290e-04 9.734400e-04 12 92832512 92832850 339 - 1.390 1.039 -1.242
ENSG00000102189 E023 22.3654475 0.0008404263 1.757134e-02 4.620240e-02 12 92842465 92842581 117 - 1.126 0.858 -0.992
ENSG00000102189 E024 24.3741578 0.0143180400 3.663028e-02 8.476653e-02 12 92851111 92851266 156 - 1.160 0.926 -0.856
ENSG00000102189 E025 18.9725876 0.0060296950 1.554559e-01 2.690020e-01 12 92852175 92852296 122 - 1.054 0.927 -0.468
ENSG00000102189 E026 16.7085284 0.0010771197 5.383182e-02 1.159568e-01 12 92852912 92853025 114 - 1.009 0.776 -0.889
ENSG00000102189 E027 10.5049360 0.0027497755 2.130823e-01 3.421784e-01 12 92853915 92853954 40 - 0.827 0.675 -0.615
ENSG00000102189 E028 15.7444833 0.0011129145 7.879657e-04 3.216084e-03 12 92857275 92857340 66 - 0.998 0.351 -2.848
ENSG00000102189 E029 14.3301704 0.0012363200 1.026334e-04 5.342087e-04 12 92857431 92857445 15 - 0.967 0.000 -13.708
ENSG00000102189 E030 14.9023284 0.0039947409 8.210501e-05 4.379466e-04 12 92857446 92857485 40 - 0.982 0.000 -13.767
ENSG00000102189 E031 19.3612796 0.0053016575 1.379515e-04 6.945677e-04 12 92864860 92864987 128 - 1.082 0.351 -3.155
ENSG00000102189 E032 0.1515154 0.0427408509 5.163067e-01   12 92879247 92879363 117 - 0.036 0.000 -7.172
ENSG00000102189 E033 11.5365866 0.0059508039 1.414667e-01 2.500298e-01 12 92891629 92891721 93 - 0.869 0.674 -0.778
ENSG00000102189 E034 0.3332198 0.0298457358 8.123575e-02   12 92905486 92905596 111 - 0.036 0.351 3.866
ENSG00000102189 E035 7.2940481 0.0073763049 2.722830e-01 4.111460e-01 12 92929043 92929331 289 - 0.699 0.542 -0.689