ENSG00000102125

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000483674 ENSG00000102125 HEK293_OSMI2_2hA HEK293_TMG_2hB TAFAZZIN protein_coding retained_intron 45.2807 72.18131 24.49565 5.170503 1.008766 -1.558711 2.093824 2.6094278 1.078199 0.2933684 0.6247517 -1.2673087 0.05480833 0.03600000 0.04390000 0.00790000 9.031673e-01 9.613742e-15 TRUE TRUE
ENST00000601016 ENSG00000102125 HEK293_OSMI2_2hA HEK293_TMG_2hB TAFAZZIN protein_coding protein_coding 45.2807 72.18131 24.49565 5.170503 1.008766 -1.558711 1.144152 0.7828246 2.421316 0.6454785 1.3563570 1.6166636 0.02930833 0.01183333 0.09836667 0.08653333 6.207650e-01 9.613742e-15 FALSE TRUE
ENST00000612460 ENSG00000102125 HEK293_OSMI2_2hA HEK293_TMG_2hB TAFAZZIN protein_coding protein_coding 45.2807 72.18131 24.49565 5.170503 1.008766 -1.558711 2.205385 5.4927786 0.000000 1.8423297 0.0000000 -9.1040165 0.03653333 0.07576667 0.00000000 -0.07576667 1.264282e-07 9.613742e-15 FALSE TRUE
ENST00000613002 ENSG00000102125 HEK293_OSMI2_2hA HEK293_TMG_2hB TAFAZZIN protein_coding protein_coding 45.2807 72.18131 24.49565 5.170503 1.008766 -1.558711 10.956333 18.6044682 7.718981 1.1439706 0.7245749 -1.2680743 0.24185833 0.25876667 0.31630000 0.05753333 4.941586e-01 9.613742e-15 FALSE TRUE
ENST00000614595 ENSG00000102125 HEK293_OSMI2_2hA HEK293_TMG_2hB TAFAZZIN protein_coding retained_intron 45.2807 72.18131 24.49565 5.170503 1.008766 -1.558711 2.600095 2.1769624 1.804531 0.3780033 0.2609818 -0.2693321 0.06682500 0.02980000 0.07306667 0.04326667 3.949687e-04 9.613742e-15 FALSE TRUE
ENST00000652390 ENSG00000102125 HEK293_OSMI2_2hA HEK293_TMG_2hB TAFAZZIN protein_coding protein_coding 45.2807 72.18131 24.49565 5.170503 1.008766 -1.558711 5.468676 10.7371192 2.217952 0.3628886 1.4237202 -2.2701601 0.11271667 0.14950000 0.09213333 -0.05736667 6.778785e-01 9.613742e-15 FALSE TRUE
ENST00000652476 ENSG00000102125 HEK293_OSMI2_2hA HEK293_TMG_2hB TAFAZZIN protein_coding retained_intron 45.2807 72.18131 24.49565 5.170503 1.008766 -1.558711 2.859711 2.3492688 1.268435 0.2807519 0.1700393 -0.8839606 0.06950833 0.03246667 0.05176667 0.01930000 1.304710e-01 9.613742e-15 FALSE FALSE
ENST00000652644 ENSG00000102125 HEK293_OSMI2_2hA HEK293_TMG_2hB TAFAZZIN protein_coding protein_coding 45.2807 72.18131 24.49565 5.170503 1.008766 -1.558711 2.982450 10.2326057 0.000000 2.5661332 0.0000000 -10.0003671 0.04446667 0.14216667 0.00000000 -0.14216667 9.613742e-15 9.613742e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102125 E001 1.133176 0.1008902488 6.086139e-01 7.282953e-01 X 154411524 154411538 15 + 0.186 0.303 0.914
ENSG00000102125 E002 1.284692 0.0549707308 8.946344e-01 9.366806e-01 X 154411539 154411540 2 + 0.316 0.301 -0.094
ENSG00000102125 E003 2.790716 0.0059375168 3.301848e-01 4.737642e-01 X 154411541 154411549 9 + 0.624 0.475 -0.691
ENSG00000102125 E004 4.747021 0.0033628650 2.374140e-02 5.928216e-02 X 154411550 154411552 3 + 0.900 0.600 -1.222
ENSG00000102125 E005 18.879770 0.0281888561 1.780975e-03 6.539034e-03 X 154411553 154411560 8 + 1.442 1.121 -1.129
ENSG00000102125 E006 20.753482 0.0321941229 2.929141e-03 1.005558e-02 X 154411561 154411561 1 + 1.475 1.166 -1.078
ENSG00000102125 E007 37.434264 0.0148666149 8.572665e-03 2.522076e-02 X 154411562 154411573 12 + 1.646 1.453 -0.661
ENSG00000102125 E008 43.767772 0.0109792522 5.891926e-03 1.832703e-02 X 154411574 154411584 11 + 1.705 1.522 -0.621
ENSG00000102125 E009 72.592308 0.0102894055 8.458529e-04 3.422780e-03 X 154411585 154411618 34 + 1.929 1.736 -0.649
ENSG00000102125 E010 81.957938 0.0087142459 2.926184e-04 1.349785e-03 X 154411619 154411649 31 + 1.983 1.787 -0.657
ENSG00000102125 E011 78.980072 0.0083014280 2.959491e-03 1.014304e-02 X 154411650 154411682 33 + 1.939 1.783 -0.527
ENSG00000102125 E012 101.978893 0.0064450084 1.606151e-02 4.287368e-02 X 154411683 154411758 76 + 2.015 1.909 -0.357
ENSG00000102125 E013 61.416042 0.0123315421 3.327604e-01 4.764387e-01 X 154411759 154411790 32 + 1.757 1.710 -0.159
ENSG00000102125 E014 42.091656 0.0139188568 5.111949e-01 6.462886e-01 X 154411791 154411791 1 + 1.498 1.577 0.271
ENSG00000102125 E015 61.041225 0.0193157830 8.600120e-01 9.137108e-01 X 154411792 154411829 38 + 1.686 1.730 0.147
ENSG00000102125 E016 55.438891 0.0289239890 9.308259e-01 9.604746e-01 X 154411830 154411843 14 + 1.646 1.689 0.143
ENSG00000102125 E017 68.972892 0.0241917906 7.484855e-01 8.357244e-01 X 154411844 154411878 35 + 1.773 1.773 -0.001
ENSG00000102125 E018 70.565680 0.0185067079 9.838444e-01 9.939652e-01 X 154411879 154411897 19 + 1.761 1.788 0.092
ENSG00000102125 E019 83.187804 0.0095759777 8.248523e-01 8.896538e-01 X 154411898 154411921 24 + 1.824 1.861 0.122
ENSG00000102125 E020 95.395659 0.0014213946 6.139279e-01 7.325176e-01 X 154411922 154411952 31 + 1.912 1.909 -0.011
ENSG00000102125 E021 11.724999 0.0015122788 3.936170e-03 1.296186e-02 X 154411953 154411978 26 + 1.231 0.960 -0.979
ENSG00000102125 E022 13.532993 0.0013130751 1.582949e-02 4.235602e-02 X 154411979 154412006 28 + 1.244 1.030 -0.769
ENSG00000102125 E023 13.478696 0.0013451189 3.240668e-05 1.912152e-04 X 154412007 154412085 79 + 1.339 0.970 -1.322
ENSG00000102125 E024 181.378534 0.0002400707 5.046881e-01 6.405910e-01 X 154412086 154412160 75 + 2.184 2.183 -0.004
ENSG00000102125 E025 146.464583 0.0002855175 4.034282e-01 5.472122e-01 X 154412161 154412180 20 + 2.052 2.100 0.162
ENSG00000102125 E026 127.362925 0.0013112896 5.029489e-01 6.389459e-01 X 154412181 154412185 5 + 1.992 2.040 0.161
ENSG00000102125 E027 144.877037 0.0005514301 4.298684e-01 5.725229e-01 X 154412186 154412202 17 + 2.048 2.096 0.161
ENSG00000102125 E028 143.119887 0.0002426437 3.859030e-01 5.301073e-01 X 154412203 154412214 12 + 2.043 2.093 0.166
ENSG00000102125 E029 59.516711 0.0005440098 2.472774e-12 5.690714e-11 X 154412215 154412714 500 + 1.923 1.605 -1.075
ENSG00000102125 E030 13.853014 0.0120922336 4.442860e-02 9.916419e-02 X 154412715 154412717 3 + 1.245 1.047 -0.710
ENSG00000102125 E031 13.668087 0.0051150121 4.343403e-02 9.735436e-02 X 154412718 154412720 3 + 1.231 1.046 -0.664
ENSG00000102125 E032 41.504911 0.0007359252 4.845140e-05 2.739420e-04 X 154412721 154412865 145 + 1.709 1.491 -0.745
ENSG00000102125 E033 25.164514 0.0007724093 3.692910e-04 1.655296e-03 X 154412866 154412919 54 + 1.512 1.271 -0.836
ENSG00000102125 E034 26.328373 0.0052236912 1.325208e-03 5.060198e-03 X 154412920 154412987 68 + 1.526 1.294 -0.802
ENSG00000102125 E035 33.875666 0.0006010767 4.881145e-06 3.483888e-05 X 154412988 154413206 219 + 1.661 1.394 -0.915
ENSG00000102125 E036 204.337162 0.0001934712 6.044908e-01 7.250284e-01 X 154413207 154413252 46 + 2.209 2.243 0.114
ENSG00000102125 E037 34.798016 0.0007630622 1.164247e-01 2.148564e-01 X 154413253 154413339 87 + 1.546 1.462 -0.290
ENSG00000102125 E038 14.478534 0.0043683173 5.283847e-01 6.613039e-01 X 154413340 154413352 13 + 1.157 1.111 -0.165
ENSG00000102125 E039 12.497338 0.0018980972 7.649353e-01 8.478510e-01 X 154413353 154413358 6 + 1.026 1.076 0.182
ENSG00000102125 E040 22.471072 0.0008404675 3.112445e-03 1.059690e-02 X 154413359 154413481 123 + 1.451 1.242 -0.727
ENSG00000102125 E041 218.702175 0.0002351757 7.373450e-01 8.275628e-01 X 154413482 154413551 70 + 2.256 2.266 0.033
ENSG00000102125 E042 151.684420 0.0002764777 3.110081e-01 4.534541e-01 X 154413552 154413567 16 + 2.117 2.102 -0.049
ENSG00000102125 E043 9.063809 0.0036830140 3.743622e-03 1.242085e-02 X 154413568 154414100 533 + 1.140 0.830 -1.154
ENSG00000102125 E044 47.982495 0.0008338277 3.566115e-01 5.010047e-01 X 154414101 154414106 6 + 1.559 1.634 0.255
ENSG00000102125 E045 88.057492 0.0008385726 6.540702e-01 7.643582e-01 X 154414107 154414190 84 + 1.848 1.887 0.133
ENSG00000102125 E046 7.874190 0.0165648309 1.245259e-01 2.264387e-01 X 154414191 154414673 483 + 1.003 0.820 -0.696
ENSG00000102125 E047 5.874425 0.0055268163 1.774976e-04 8.675317e-04 X 154418475 154418545 71 + 1.068 0.600 -1.842
ENSG00000102125 E048 5.367947 0.0035202770 9.636995e-06 6.431465e-05 X 154418546 154418602 57 + 1.087 0.529 -2.236
ENSG00000102125 E049 22.155967 0.0123966892 7.817779e-05 4.193484e-04 X 154418603 154419542 940 + 1.519 1.182 -1.175
ENSG00000102125 E050 136.416473 0.0035003682 2.748347e-01 4.140585e-01 X 154419543 154419545 3 + 2.086 2.056 -0.098
ENSG00000102125 E051 251.517323 0.0011610082 9.592863e-01 9.784626e-01 X 154419546 154419623 78 + 2.311 2.333 0.073
ENSG00000102125 E052 46.252950 0.0004960906 7.558372e-06 5.162554e-05 X 154419624 154419704 81 + 1.761 1.533 -0.773
ENSG00000102125 E053 110.014135 0.0003363452 7.953112e-01 8.692729e-01 X 154419705 154419746 42 + 1.963 1.972 0.029
ENSG00000102125 E054 77.488603 0.0004766518 1.970025e-05 1.223857e-04 X 154419747 154419990 244 + 1.939 1.771 -0.569
ENSG00000102125 E055 43.033449 0.0005406247 2.068680e-02 5.292726e-02 X 154419991 154420031 41 + 1.651 1.533 -0.402
ENSG00000102125 E056 264.292407 0.0002147098 9.386559e-02 1.811724e-01 X 154420032 154420094 63 + 2.299 2.362 0.210
ENSG00000102125 E057 26.351596 0.0007474773 1.067023e-01 2.006814e-01 X 154420095 154420211 117 + 1.244 1.394 0.524
ENSG00000102125 E058 257.149616 0.0002587854 4.002772e-03 1.314986e-02 X 154420212 154420264 53 + 2.258 2.355 0.325
ENSG00000102125 E059 4.589337 0.1020725946 7.667634e-01 8.491619e-01 X 154420325 154420459 135 + 0.624 0.710 0.362
ENSG00000102125 E060 351.585157 0.0002251893 3.969684e-02 9.046142e-02 X 154420658 154420735 78 + 2.419 2.486 0.222
ENSG00000102125 E061 15.099196 0.0072538943 1.842409e-02 4.806439e-02 X 154420736 154420902 167 + 1.294 1.082 -0.753
ENSG00000102125 E062 656.429821 0.0026536618 8.189552e-04 3.327085e-03 X 154420903 154421136 234 + 2.651 2.770 0.396
ENSG00000102125 E063 421.141152 0.0039782916 6.864106e-04 2.849713e-03 X 154421137 154421256 120 + 2.437 2.584 0.489
ENSG00000102125 E064 682.538697 0.0052452319 2.089885e-06 1.619116e-05 X 154421257 154421726 470 + 2.603 2.802 0.663