ENSG00000102119

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369835 ENSG00000102119 HEK293_OSMI2_2hA HEK293_TMG_2hB EMD protein_coding protein_coding 327.1164 637.9035 168.902 27.71318 3.333638 -1.917089 37.62239 57.0734 33.22825 11.743967 1.419158 -0.780227 0.1157875 0.0882000 0.1972000 0.10900000 4.003437e-03 4.503065e-07 FALSE TRUE
ENST00000369842 ENSG00000102119 HEK293_OSMI2_2hA HEK293_TMG_2hB EMD protein_coding protein_coding 327.1164 637.9035 168.902 27.71318 3.333638 -1.917089 166.16718 312.0618 95.72199 28.733138 2.963539 -1.704805 0.5031625 0.4871000 0.5665333 0.07943333 1.448797e-01 4.503065e-07 FALSE TRUE
ENST00000492448 ENSG00000102119 HEK293_OSMI2_2hA HEK293_TMG_2hB EMD protein_coding processed_transcript 327.1164 637.9035 168.902 27.71318 3.333638 -1.917089 78.65917 191.7771 16.72333 4.343266 3.370727 -3.518709 0.2210708 0.3016667 0.0984000 -0.20326667 4.503065e-07 4.503065e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102119 E001 139.53276 0.0338333836 2.649060e-06 2.007185e-05 X 154379273 154379294 22 + 2.353 1.913 -1.473
ENSG00000102119 E002 268.38196 0.0266798704 3.078286e-08 3.456039e-07 X 154379295 154379340 46 + 2.646 2.190 -1.523
ENSG00000102119 E003 367.73696 0.0280841478 2.877301e-08 3.250811e-07 X 154379341 154379360 20 + 2.786 2.324 -1.537
ENSG00000102119 E004 761.94414 0.0126622351 2.427916e-07 2.290014e-06 X 154379361 154379403 43 + 2.990 2.698 -0.969
ENSG00000102119 E005 873.04762 0.0073269544 2.342771e-06 1.795433e-05 X 154379404 154379416 13 + 2.990 2.780 -0.697
ENSG00000102119 E006 911.30613 0.0061432219 4.907853e-06 3.500060e-05 X 154379417 154379427 11 + 2.992 2.804 -0.625
ENSG00000102119 E007 1427.94277 0.0040029921 1.094365e-06 9.008614e-06 X 154379428 154379484 57 + 3.168 3.006 -0.538
ENSG00000102119 E008 1368.39840 0.0023916407 1.566568e-07 1.532646e-06 X 154379485 154379508 24 + 3.135 2.991 -0.477
ENSG00000102119 E009 1269.17540 0.0023124016 6.883315e-05 3.744396e-04 X 154379509 154379524 16 + 3.077 2.966 -0.369
ENSG00000102119 E010 1295.79154 0.0028791503 1.533837e-03 5.746105e-03 X 154379525 154379537 13 + 3.075 2.978 -0.322
ENSG00000102119 E011 1440.34295 0.0012578487 1.964621e-02 5.073010e-02 X 154379538 154379562 25 + 3.089 3.031 -0.190
ENSG00000102119 E012 992.33346 0.0009536489 7.058021e-01 8.041024e-01 X 154379563 154379566 4 + 2.883 2.879 -0.012
ENSG00000102119 E013 28.76249 0.0024770863 1.269639e-03 4.876022e-03 X 154379625 154379689 65 + 1.553 1.297 -0.884
ENSG00000102119 E014 2271.62302 0.0003166291 3.443922e-01 4.884854e-01 X 154379690 154379794 105 + 3.239 3.239 -0.001
ENSG00000102119 E015 2567.08249 0.0000637043 2.516155e-01 3.878805e-01 X 154379942 154380019 78 + 3.294 3.291 -0.011
ENSG00000102119 E016 147.59695 0.0007579733 7.072632e-08 7.391267e-07 X 154380020 154380233 214 + 2.213 2.007 -0.691
ENSG00000102119 E017 2330.62366 0.0005292266 1.696998e-01 2.878090e-01 X 154380234 154380276 43 + 3.246 3.253 0.025
ENSG00000102119 E018 2951.03473 0.0005654357 1.742734e-03 6.416896e-03 X 154380277 154380367 91 + 3.329 3.360 0.104
ENSG00000102119 E019 77.53578 0.0089203323 4.396851e-09 5.787329e-08 X 154380368 154380462 95 + 2.060 1.680 -1.278
ENSG00000102119 E020 115.60419 0.0037996200 1.620694e-09 2.311144e-08 X 154380565 154380752 188 + 2.174 1.881 -0.985
ENSG00000102119 E021 2483.03109 0.0013167611 1.570929e-05 9.978800e-05 X 154380753 154380802 50 + 3.220 3.293 0.242
ENSG00000102119 E022 108.06077 0.0082300709 2.167138e-03 7.741554e-03 X 154380803 154380881 79 + 2.071 1.882 -0.635
ENSG00000102119 E023 4399.34378 0.0013435095 8.961558e-15 2.968596e-13 X 154380882 154381004 123 + 3.421 3.549 0.425
ENSG00000102119 E024 4898.85398 0.0012442350 1.522375e-18 8.194371e-17 X 154381005 154381230 226 + 3.459 3.597 0.459
ENSG00000102119 E025 965.75120 0.0003647403 1.254053e-18 6.834769e-17 X 154381231 154381331 101 + 2.747 2.892 0.482
ENSG00000102119 E026 1056.26123 0.0045514122 2.711211e-04 1.262240e-03 X 154381332 154381387 56 + 2.808 2.929 0.402
ENSG00000102119 E027 1156.89757 0.0040040947 1.462823e-04 7.310955e-04 X 154381388 154381574 187 + 2.850 2.968 0.393