ENSG00000102081

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370470 ENSG00000102081 HEK293_OSMI2_2hA HEK293_TMG_2hB FMR1 protein_coding protein_coding 20.65475 11.92548 29.08449 0.5880314 0.6975304 1.285489 2.5118905 1.8948755 3.2469087 0.37256201 0.13091792 0.7738065 0.12447500 0.16000000 0.11183333 -0.04816667 4.634006e-01 1.838412e-34 FALSE TRUE
ENST00000370475 ENSG00000102081 HEK293_OSMI2_2hA HEK293_TMG_2hB FMR1 protein_coding protein_coding 20.65475 11.92548 29.08449 0.5880314 0.6975304 1.285489 1.4999458 0.5264194 3.4215819 0.29867308 0.05696503 2.6774405 0.06445833 0.04690000 0.11786667 0.07096667 1.590605e-01 1.838412e-34 FALSE TRUE
ENST00000495717 ENSG00000102081 HEK293_OSMI2_2hA HEK293_TMG_2hB FMR1 protein_coding protein_coding 20.65475 11.92548 29.08449 0.5880314 0.6975304 1.285489 1.0696246 1.3864830 0.8622989 0.20950715 0.10777817 -0.6789036 0.06648750 0.11830000 0.02953333 -0.08876667 2.421304e-05 1.838412e-34 FALSE TRUE
ENST00000687593 ENSG00000102081 HEK293_OSMI2_2hA HEK293_TMG_2hB FMR1 protein_coding protein_coding 20.65475 11.92548 29.08449 0.5880314 0.6975304 1.285489 7.6581424 4.0841508 10.8846382 0.91013215 0.11560571 1.4119821 0.35253750 0.33666667 0.37483333 0.03816667 8.181801e-01 1.838412e-34 FALSE TRUE
ENST00000691111 ENSG00000102081 HEK293_OSMI2_2hA HEK293_TMG_2hB FMR1 protein_coding protein_coding 20.65475 11.92548 29.08449 0.5880314 0.6975304 1.285489 2.7130126 1.0917619 3.8363590 0.23917523 0.36176669 1.8036810 0.12134583 0.09076667 0.13150000 0.04073333 3.500728e-01 1.838412e-34 FALSE TRUE
ENST00000691793 ENSG00000102081 HEK293_OSMI2_2hA HEK293_TMG_2hB FMR1 protein_coding retained_intron 20.65475 11.92548 29.08449 0.5880314 0.6975304 1.285489 1.4017082 0.1447919 2.7269161 0.07492265 0.12999997 4.1441491 0.06335833 0.01273333 0.09380000 0.08106667 1.647024e-04 1.838412e-34 TRUE TRUE
ENST00000693452 ENSG00000102081 HEK293_OSMI2_2hA HEK293_TMG_2hB FMR1 protein_coding nonsense_mediated_decay 20.65475 11.92548 29.08449 0.5880314 0.6975304 1.285489 0.3512624 1.8132036 0.0000000 0.13426915 0.00000000 -7.5103319 0.03022500 0.15296667 0.00000000 -0.15296667 1.838412e-34 1.838412e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102081 E001 0.6976476 0.1132912432 4.144140e-01 5.578335e-01 X 147911822 147911918 97 + 0.144 0.319 1.457
ENSG00000102081 E002 5.5745222 0.0029641757 1.683976e-01 2.860971e-01 X 147911919 147911950 32 + 0.828 0.677 -0.607
ENSG00000102081 E003 5.8732867 0.0027007376 1.172292e-01 2.159899e-01 X 147911951 147911955 5 + 0.852 0.677 -0.703
ENSG00000102081 E004 5.8732867 0.0027007376 1.172292e-01 2.159899e-01 X 147911956 147911962 7 + 0.852 0.677 -0.703
ENSG00000102081 E005 6.3108811 0.0026618011 6.660520e-02 1.377378e-01 X 147911963 147912051 89 + 0.887 0.677 -0.837
ENSG00000102081 E006 1.4600323 0.2724999639 6.160707e-02 1.293273e-01 X 147912052 147912069 18 + 0.471 0.000 -23.103
ENSG00000102081 E007 0.4375944 0.0257887461 3.227563e-01 4.660820e-01 X 147912070 147912075 6 + 0.202 0.000 -21.374
ENSG00000102081 E008 0.4375944 0.0257887461 3.227563e-01 4.660820e-01 X 147912076 147912078 3 + 0.202 0.000 -21.374
ENSG00000102081 E009 0.2924217 0.0272165748 5.583856e-01   X 147912079 147912079 1 + 0.144 0.000 -20.790
ENSG00000102081 E010 0.1451727 0.0429619597 1.000000e+00   X 147912080 147912081 2 + 0.078 0.000 -19.790
ENSG00000102081 E011 0.5503986 0.0207452185 1.895774e-01 3.132257e-01 X 147912082 147912084 3 + 0.078 0.317 2.446
ENSG00000102081 E012 0.5503986 0.0207452185 1.895774e-01 3.132257e-01 X 147912085 147912093 9 + 0.078 0.317 2.446
ENSG00000102081 E013 6.4004873 0.0340395941 6.465172e-01 7.583980e-01 X 147912094 147912122 29 + 0.787 0.907 0.464
ENSG00000102081 E014 16.1554049 0.0011113097 4.865131e-01 6.242423e-01 X 147912123 147912158 36 + 1.199 1.190 -0.030
ENSG00000102081 E015 15.7867107 0.0011390260 4.276235e-01 5.704869e-01 X 147912159 147912161 3 + 1.193 1.175 -0.065
ENSG00000102081 E016 18.0345090 0.0010891652 1.456533e-01 2.557376e-01 X 147912162 147912170 9 + 1.264 1.190 -0.261
ENSG00000102081 E017 19.3685105 0.0012961650 5.302775e-02 1.145307e-01 X 147912171 147912175 5 + 1.304 1.190 -0.401
ENSG00000102081 E018 21.3163985 0.0012226329 2.808963e-02 6.818876e-02 X 147912176 147912179 4 + 1.349 1.219 -0.453
ENSG00000102081 E019 37.0663737 0.0045662702 1.020671e-01 1.936555e-01 X 147912180 147912230 51 + 1.560 1.501 -0.203
ENSG00000102081 E020 0.2214452 0.0384428180 2.024411e-01   X 147912469 147912727 259 + 0.000 0.187 22.406
ENSG00000102081 E021 2.9391283 0.0563219535 7.846946e-01 8.619207e-01 X 147912728 147913077 350 + 0.575 0.566 -0.042
ENSG00000102081 E022 6.5214595 0.0028923121 4.642404e-03 1.493825e-02 X 147913078 147914451 1374 + 0.694 1.088 1.512
ENSG00000102081 E023 0.2924217 0.0272165748 5.583856e-01   X 147917726 147917827 102 + 0.144 0.000 -20.790
ENSG00000102081 E024 52.9401964 0.0024364011 1.674020e-02 4.436676e-02 X 147921933 147921985 53 + 1.720 1.638 -0.279
ENSG00000102081 E025 1.8604401 0.0622811492 9.572501e-02 1.839772e-01 X 147924919 147925055 137 + 0.502 0.187 -2.012
ENSG00000102081 E026 87.8170510 0.0008937521 1.885704e-02 4.901970e-02 X 147925540 147925633 94 + 1.928 1.885 -0.145
ENSG00000102081 E027 0.7447779 0.0978273807 1.446321e-01 2.543313e-01 X 147927670 147927735 66 + 0.298 0.000 -22.113
ENSG00000102081 E028 2.2387139 0.0642158510 4.759509e-03 1.525934e-02 X 147927736 147928321 586 + 0.598 0.000 -23.700
ENSG00000102081 E029 103.7826120 0.0003317098 7.154879e-03 2.162580e-02 X 147928322 147928388 67 + 1.999 1.955 -0.150
ENSG00000102081 E030 62.6470629 0.0006633550 2.690575e-02 6.579342e-02 X 147928389 147928393 5 + 1.785 1.733 -0.175
ENSG00000102081 E031 0.2944980 0.3812392691 6.705606e-01   X 147928394 147928658 265 + 0.144 0.000 -20.789
ENSG00000102081 E032 137.1986954 0.0002781335 3.337750e-02 7.853333e-02 X 147928659 147928807 149 + 2.110 2.099 -0.039
ENSG00000102081 E033 103.1290241 0.0008321560 7.176087e-02 1.462775e-01 X 147929948 147930041 94 + 1.985 1.973 -0.043
ENSG00000102081 E034 137.1016505 0.0064740686 2.367032e-01 3.703683e-01 X 147930128 147930244 117 + 2.106 2.105 -0.006
ENSG00000102081 E035 1.0371996 0.0240718393 5.502585e-02 1.180442e-01 X 147930873 147930964 92 + 0.377 0.000 -22.597
ENSG00000102081 E036 169.1734678 0.0037503475 8.205150e-01 8.867992e-01 X 147932425 147932595 171 + 2.178 2.227 0.166
ENSG00000102081 E037 127.0138569 0.0021228440 2.228025e-01 3.537158e-01 X 147932685 147932763 79 + 2.066 2.076 0.032
ENSG00000102081 E038 1.9336067 0.0076744973 4.985010e-03 1.588809e-02 X 147933401 147933540 140 + 0.552 0.000 -23.491
ENSG00000102081 E039 1.1739533 0.0121970975 3.552021e-02 8.265304e-02 X 147933541 147933687 147 + 0.411 0.000 -22.790
ENSG00000102081 E040 81.3205274 0.0016761831 3.245907e-02 7.673260e-02 X 147936504 147936509 6 + 1.890 1.847 -0.143
ENSG00000102081 E041 162.5245090 0.0014182218 6.146269e-02 1.290943e-01 X 147936510 147936613 104 + 2.178 2.172 -0.022
ENSG00000102081 E042 173.2325972 0.0014043170 4.149535e-01 5.583574e-01 X 147937466 147937600 135 + 2.196 2.227 0.103
ENSG00000102081 E043 28.1656629 0.0007397381 7.537929e-01 8.395976e-01 X 147938099 147938161 63 + 1.406 1.485 0.271
ENSG00000102081 E044 0.7374030 0.0156441943 6.314902e-01 7.464850e-01 X 147940157 147940575 419 + 0.253 0.186 -0.558
ENSG00000102081 E045 156.2610111 0.0016789829 3.062315e-01 4.483916e-01 X 147940576 147940662 87 + 2.155 2.177 0.074
ENSG00000102081 E046 237.1257317 0.0002751336 3.745149e-02 8.631269e-02 X 147943131 147943326 196 + 2.339 2.346 0.021
ENSG00000102081 E047 54.3582440 0.0004340444 8.095728e-19 4.522888e-17 X 147943327 147944692 1366 + 1.810 1.308 -1.717
ENSG00000102081 E048 11.1258957 0.0070723332 2.847968e-04 1.318103e-03 X 147944693 147944868 176 + 1.141 0.724 -1.579
ENSG00000102081 E049 63.1264231 0.0018673710 2.059404e-01 3.336023e-01 X 147944869 147944883 15 + 1.774 1.767 -0.025
ENSG00000102081 E050 68.2415784 0.0034674268 2.439020e-01 3.787788e-01 X 147944884 147944904 21 + 1.806 1.802 -0.015
ENSG00000102081 E051 104.3107866 0.0014611230 5.483061e-01 6.781722e-01 X 147944905 147944943 39 + 1.975 2.009 0.114
ENSG00000102081 E052 97.5398044 0.0004896570 2.730973e-01 4.120734e-01 X 147944944 147944952 9 + 1.952 1.968 0.051
ENSG00000102081 E053 148.9918674 0.0003665933 2.242669e-01 3.555341e-01 X 147944953 147945024 72 + 2.133 2.153 0.067
ENSG00000102081 E054 102.8698663 0.0003239103 3.554142e-01 4.997600e-01 X 147945025 147945051 27 + 1.973 1.997 0.080
ENSG00000102081 E055 151.1334049 0.0013749060 1.188418e-01 2.182943e-01 X 147945534 147945616 83 + 2.144 2.148 0.015
ENSG00000102081 E056 1.5262013 0.0452336870 1.549411e-01 2.683323e-01 X 147945617 147945715 99 + 0.444 0.187 -1.727
ENSG00000102081 E057 9.3152050 0.0018006046 3.054582e-08 3.432681e-07 X 147948413 147948415 3 + 0.677 1.319 2.404
ENSG00000102081 E058 16.0569664 0.0055979039 1.154329e-07 1.159574e-06 X 147948416 147948682 267 + 0.968 1.498 1.879
ENSG00000102081 E059 26.8312839 0.0008040464 1.568442e-02 4.203019e-02 X 147948683 147948687 5 + 1.445 1.319 -0.434
ENSG00000102081 E060 52.4780156 0.0004600840 1.309552e-02 3.612902e-02 X 147948688 147948733 46 + 1.714 1.638 -0.258
ENSG00000102081 E061 1197.7651000 0.0114297760 2.044453e-04 9.830594e-04 X 147948734 147951125 2392 + 2.969 3.176 0.687