ENSG00000102078

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000465988 ENSG00000102078 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A14 protein_coding processed_transcript 30.37585 33.8701 30.76329 4.997402 1.462685 -0.1387594 3.2368918 3.135443 2.7100666 0.7028807 0.42424751 -0.2096211 0.10624583 0.09063333 0.088533333 -0.002100000 9.562436e-01 5.988073e-42   FALSE
ENST00000471795 ENSG00000102078 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A14 protein_coding processed_transcript 30.37585 33.8701 30.76329 4.997402 1.462685 -0.1387594 2.1704665 1.702501 1.3747786 0.4726724 0.29176312 -0.3064491 0.07242500 0.04926667 0.045300000 -0.003966667 9.259476e-01 5.988073e-42 FALSE TRUE
ENST00000478474 ENSG00000102078 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A14 protein_coding processed_transcript 30.37585 33.8701 30.76329 4.997402 1.462685 -0.1387594 0.8488861 2.091156 0.1594842 0.4783731 0.07974395 -3.6319604 0.02738333 0.06060000 0.005233333 -0.055366667 4.817142e-04 5.988073e-42 FALSE TRUE
ENST00000495156 ENSG00000102078 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A14 protein_coding processed_transcript 30.37585 33.8701 30.76329 4.997402 1.462685 -0.1387594 2.2629898 0.000000 4.7120291 0.0000000 0.56655671 8.8832631 0.08000417 0.00000000 0.152066667 0.152066667 5.988073e-42 5.988073e-42 FALSE TRUE
ENST00000543953 ENSG00000102078 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A14 protein_coding protein_coding 30.37585 33.8701 30.76329 4.997402 1.462685 -0.1387594 12.3492832 14.315086 13.0819613 1.6438907 1.19960542 -0.1298626 0.40842083 0.42780000 0.427400000 -0.000400000 1.000000e+00 5.988073e-42 FALSE TRUE
MSTRG.34872.1 ENSG00000102078 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A14 protein_coding   30.37585 33.8701 30.76329 4.997402 1.462685 -0.1387594 1.8008131 4.036954 0.3022347 0.6125405 0.18450093 -3.6961335 0.05632083 0.11903333 0.010033333 -0.109000000 1.337806e-02 5.988073e-42 TRUE TRUE
MSTRG.34872.9 ENSG00000102078 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A14 protein_coding   30.37585 33.8701 30.76329 4.997402 1.462685 -0.1387594 3.2573745 4.875044 2.3782556 1.1021245 0.10665647 -1.0324144 0.10347083 0.14096667 0.078000000 -0.062966667 1.154694e-02 5.988073e-42 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102078 E001 0.9200498 0.0251779328 1.903067e-01 3.141681e-01 X 130339834 130339887 54 + 0.137 0.384 1.934
ENSG00000102078 E002 1.4381831 0.0095408301 5.756187e-01 7.011776e-01 X 130339888 130339899 12 + 0.325 0.433 0.618
ENSG00000102078 E003 1.5854321 0.0089389606 8.712543e-01 9.212053e-01 X 130339900 130339900 1 + 0.395 0.433 0.203
ENSG00000102078 E004 2.0303117 0.0086445317 3.961836e-01 5.399698e-01 X 130339901 130339909 9 + 0.395 0.551 0.786
ENSG00000102078 E005 1.8486073 0.0987437850 7.076872e-01 8.055165e-01 X 130339910 130339910 1 + 0.395 0.508 0.582
ENSG00000102078 E006 1.8486073 0.0987437850 7.076872e-01 8.055165e-01 X 130339911 130339912 2 + 0.395 0.508 0.582
ENSG00000102078 E007 3.9426209 0.0095830206 5.324015e-01 6.647714e-01 X 130339913 130339918 6 + 0.638 0.744 0.444
ENSG00000102078 E008 92.0747561 0.0002981054 3.474238e-02 8.115308e-02 X 130339919 130339976 58 + 2.002 1.938 -0.214
ENSG00000102078 E009 1.4381831 0.0095408301 5.756187e-01 7.011776e-01 X 130340052 130340106 55 + 0.325 0.433 0.618
ENSG00000102078 E010 13.3202163 0.0013841858 3.813974e-02 8.762169e-02 X 130340107 130340133 27 + 1.248 1.073 -0.625
ENSG00000102078 E011 19.5599293 0.0009247394 9.622952e-04 3.829432e-03 X 130340134 130340278 145 + 1.437 1.199 -0.830
ENSG00000102078 E012 11.6939119 0.0018527076 1.719009e-02 4.536238e-02 X 130340279 130340344 66 + 1.220 1.005 -0.774
ENSG00000102078 E013 4.7167471 0.0034016237 6.064772e-02 1.277210e-01 X 130340345 130340353 9 + 0.885 0.646 -0.966
ENSG00000102078 E014 82.5265053 0.0003310194 6.131457e-03 1.895446e-02 X 130345182 130345184 3 + 1.972 1.881 -0.308
ENSG00000102078 E015 85.8768734 0.0003160166 3.536936e-03 1.183165e-02 X 130345185 130345185 1 + 1.992 1.897 -0.322
ENSG00000102078 E016 86.6831726 0.0003139768 5.838118e-03 1.818564e-02 X 130345186 130345187 2 + 1.992 1.903 -0.301
ENSG00000102078 E017 135.1826066 0.0002251867 1.814549e-06 1.424915e-05 X 130345188 130345275 88 + 2.204 2.075 -0.430
ENSG00000102078 E018 185.1269867 0.0006849053 3.014909e-07 2.788894e-06 X 130346544 130346691 148 + 2.337 2.208 -0.432
ENSG00000102078 E019 0.1451727 0.0434764613 3.821058e-01   X 130349248 130349250 3 + 0.137 0.000 -8.736
ENSG00000102078 E020 152.4509320 0.0020664652 7.349241e-02 1.491139e-01 X 130349251 130349345 95 + 2.212 2.158 -0.181
ENSG00000102078 E021 0.4386386 0.0959714024 4.330582e-01 5.755083e-01 X 130349346 130349674 329 + 0.241 0.108 -1.387
ENSG00000102078 E022 10.8547702 0.0131368596 7.569151e-01 8.418884e-01 X 130349824 130349867 44 + 1.042 1.083 0.148
ENSG00000102078 E023 121.4416193 0.0002587831 2.272201e-01 3.590830e-01 X 130350646 130350731 86 + 2.099 2.074 -0.084
ENSG00000102078 E024 164.1383920 0.0002257276 2.074630e-01 3.354607e-01 X 130358640 130358735 96 + 2.227 2.206 -0.070
ENSG00000102078 E025 2.9771596 0.2223942750 2.367557e-02 5.914193e-02 X 130358736 130358987 252 + 0.844 0.272 -2.778
ENSG00000102078 E026 4.4211904 0.0038198990 1.890067e-01 3.124997e-01 X 130359047 130359139 93 + 0.817 0.646 -0.702
ENSG00000102078 E027 194.1857469 0.0002447479 5.469396e-01 6.770212e-01 X 130364628 130364752 125 + 2.268 2.296 0.093
ENSG00000102078 E028 18.5034239 0.0124494063 3.680517e-01 5.124550e-01 X 130364753 130365036 284 + 1.220 1.324 0.365
ENSG00000102078 E029 23.3102546 0.0235066357 3.334395e-01 4.771658e-01 X 130365242 130365540 299 + 1.432 1.341 -0.315
ENSG00000102078 E030 245.8746511 0.0001725615 4.124524e-03 1.349019e-02 X 130365541 130365676 136 + 2.340 2.418 0.258
ENSG00000102078 E031 212.7752268 0.0002027207 9.063520e-06 6.083461e-05 X 130371564 130371644 81 + 2.249 2.371 0.407
ENSG00000102078 E032 387.7756402 0.0019837045 3.895241e-15 1.362270e-13 X 130372909 130373361 453 + 2.442 2.656 0.712