ENSG00000102054

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330735 ENSG00000102054 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP7 protein_coding retained_intron 255.7989 183.6094 339.6732 28.09366 9.497835 0.8874713 23.50343 46.05646 6.685029 17.065933 0.4400486 -2.782555 0.12925833 0.23603333 0.01963333 -0.21640000 1.612200e-14 1.6122e-14 FALSE TRUE
ENST00000380087 ENSG00000102054 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP7 protein_coding protein_coding 255.7989 183.6094 339.6732 28.09366 9.497835 0.8874713 21.45981 11.47533 32.957673 2.019961 1.8437937 1.521260 0.07977083 0.06326667 0.09713333 0.03386667 1.433946e-01 1.6122e-14 FALSE TRUE
ENST00000404022 ENSG00000102054 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP7 protein_coding protein_coding 255.7989 183.6094 339.6732 28.09366 9.497835 0.8874713 66.93729 38.72818 98.662544 2.305345 0.8194202 1.348892 0.24290833 0.21703333 0.29090000 0.07386667 1.098192e-01 1.6122e-14 FALSE TRUE
MSTRG.33950.3 ENSG00000102054 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP7 protein_coding   255.7989 183.6094 339.6732 28.09366 9.497835 0.8874713 111.05064 73.30759 157.431987 7.956934 8.0723985 1.102589 0.41938333 0.40430000 0.46290000 0.05860000 2.293540e-01 1.6122e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000102054 E001 1.404773 0.0397765051 5.806674e-01 7.053591e-01 X 16839283 16839390 108 - 0.330 0.456 0.710
ENSG00000102054 E002 22.240857 0.0069698334 2.606554e-04 1.219333e-03 X 16844341 16844649 309 - 1.204 1.546 1.189
ENSG00000102054 E003 24.750090 0.0231116757 1.303350e-15 4.860546e-14 X 16844650 16844653 4 - 0.839 1.759 3.255
ENSG00000102054 E004 283.202180 0.0029596810 4.102842e-28 5.844144e-26 X 16844654 16844689 36 - 2.242 2.656 1.383
ENSG00000102054 E005 2887.575697 0.0045575940 7.599660e-10 1.151878e-08 X 16844690 16845027 338 - 3.346 3.576 0.764
ENSG00000102054 E006 1844.726608 0.0019272745 1.498679e-04 7.463924e-04 X 16845028 16845103 76 - 3.204 3.325 0.405
ENSG00000102054 E007 1279.665375 0.0013502159 1.717068e-02 4.532126e-02 X 16845828 16845870 43 - 3.061 3.147 0.285
ENSG00000102054 E008 1378.550568 0.0007546690 2.596827e-05 1.568603e-04 X 16845871 16845938 68 - 3.085 3.192 0.353
ENSG00000102054 E009 56.989111 0.0005793505 1.705295e-05 1.074334e-04 X 16845939 16848990 3052 - 1.809 1.628 -0.611
ENSG00000102054 E010 6.513701 0.0026043956 3.895022e-01 5.335851e-01 X 16848991 16849243 253 - 0.893 0.819 -0.285
ENSG00000102054 E011 1336.156528 0.0010215726 6.201563e-07 5.385842e-06 X 16849244 16849301 58 - 3.062 3.189 0.420
ENSG00000102054 E012 1248.083049 0.0013342494 6.724084e-05 3.668099e-04 X 16852046 16852122 77 - 3.038 3.151 0.374
ENSG00000102054 E013 26.683963 0.0223646380 1.123341e-01 2.089583e-01 X 16852123 16852280 158 - 1.468 1.337 -0.454
ENSG00000102054 E014 59.413261 0.0003904692 5.330208e-01 6.652691e-01 X 16852416 16852550 135 - 1.743 1.812 0.234
ENSG00000102054 E015 634.434116 0.0026442972 1.372615e-01 2.442610e-01 X 16852551 16852551 1 - 2.761 2.834 0.245
ENSG00000102054 E016 1270.918387 0.0013271378 8.765883e-02 1.715763e-01 X 16852552 16852628 77 - 3.065 3.132 0.221
ENSG00000102054 E017 47.632852 0.0141276237 1.669807e-01 2.842687e-01 X 16852629 16852748 120 - 1.699 1.616 -0.281
ENSG00000102054 E018 1663.306512 0.0006526758 1.492821e-01 2.606884e-01 X 16852749 16852875 127 - 3.187 3.242 0.184
ENSG00000102054 E019 207.728898 0.0236420633 1.381259e-02 3.780234e-02 X 16852876 16853681 806 - 2.361 2.186 -0.584
ENSG00000102054 E020 2066.012396 0.0014842178 4.751832e-01 6.139191e-01 X 16853682 16853842 161 - 3.295 3.311 0.051
ENSG00000102054 E021 2014.999768 0.0006738456 2.511153e-04 1.180033e-03 X 16857594 16857709 116 - 3.299 3.278 -0.068
ENSG00000102054 E022 2064.405354 0.0003777390 2.353131e-09 3.256345e-08 X 16858676 16858822 147 - 3.315 3.279 -0.121
ENSG00000102054 E023 1082.272411 0.0001154028 4.822681e-26 5.775237e-24 X 16858823 16858849 27 - 3.055 2.965 -0.299
ENSG00000102054 E024 956.901906 0.0003275897 6.519729e-23 5.731523e-21 X 16862955 16862956 2 - 3.007 2.898 -0.360
ENSG00000102054 E025 1925.768240 0.0001574672 1.495701e-33 3.279583e-31 X 16862957 16863100 144 - 3.302 3.218 -0.278
ENSG00000102054 E026 1037.963535 0.0002045317 4.026514e-17 1.815784e-15 X 16869076 16869115 40 - 3.030 2.957 -0.242
ENSG00000102054 E027 1308.049710 0.0010037057 6.315658e-11 1.151128e-09 X 16869116 16869220 105 - 3.133 3.048 -0.284
ENSG00000102054 E028 1.141585 0.0183835812 7.336940e-01 8.248588e-01 X 16869221 16869254 34 - 0.330 0.286 -0.282
ENSG00000102054 E029 90.603622 0.0027859717 1.864932e-05 1.165179e-04 X 16869494 16870037 544 - 2.004 1.836 -0.566
ENSG00000102054 E030 583.469458 0.0025454283 3.825332e-07 3.461656e-06 X 16870038 16870046 9 - 2.793 2.675 -0.393
ENSG00000102054 E031 1298.757916 0.0045450913 5.266379e-05 2.950639e-04 X 16870047 16870362 316 - 3.137 3.027 -0.366