ENSG00000101974

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327569 ENSG00000101974 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11C protein_coding protein_coding 12.67722 5.631894 19.27244 0.05412946 0.8415926 1.773036 0.9550606 0.0000000 0.6534454 0.00000000 0.3427725 6.051906 0.06148750 0.00000000 0.03546667 0.03546667 3.873588e-01 2.067651e-33 FALSE TRUE
ENST00000361648 ENSG00000101974 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11C protein_coding protein_coding 12.67722 5.631894 19.27244 0.05412946 0.8415926 1.773036 2.6734044 1.6573344 5.5452993 0.09680019 0.5648888 1.736321 0.22110417 0.29453333 0.29153333 -0.00300000 1.000000e+00 2.067651e-33 FALSE TRUE
ENST00000433868 ENSG00000101974 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11C protein_coding protein_coding 12.67722 5.631894 19.27244 0.05412946 0.8415926 1.773036 1.1581805 2.8827710 0.0000000 0.29181978 0.0000000 -8.176308 0.21608333 0.51240000 0.00000000 -0.51240000 2.067651e-33 2.067651e-33 FALSE TRUE
ENST00000450801 ENSG00000101974 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11C protein_coding protein_coding 12.67722 5.631894 19.27244 0.05412946 0.8415926 1.773036 0.1862906 0.3827853 0.0746381 0.20039239 0.0746381 -2.214362 0.02336667 0.06740000 0.00380000 -0.06360000 2.587506e-01 2.067651e-33 FALSE TRUE
ENST00000682941 ENSG00000101974 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11C protein_coding protein_coding 12.67722 5.631894 19.27244 0.05412946 0.8415926 1.773036 2.1102635 0.4018819 5.0070190 0.13022166 0.2445638 3.606528 0.14197083 0.07166667 0.25973333 0.18806667 1.851795e-03 2.067651e-33 FALSE TRUE
MSTRG.34986.7 ENSG00000101974 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11C protein_coding   12.67722 5.631894 19.27244 0.05412946 0.8415926 1.773036 3.7501595 0.0000000 4.8101556 0.00000000 1.0198631 8.912936 0.21596667 0.00000000 0.24580000 0.24580000 1.107319e-12 2.067651e-33 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101974 E001 0.1515154 0.0425176539 1.000000e+00   X 139726346 139726347 2 - 0.055 0.001 -6.142
ENSG00000101974 E002 0.3332198 0.0293600455 2.510863e-01   X 139726348 139726348 1 - 0.055 0.250 2.515
ENSG00000101974 E003 0.3332198 0.0293600455 2.510863e-01   X 139726349 139726352 4 - 0.055 0.250 2.515
ENSG00000101974 E004 69.1806939 0.0409754827 7.793756e-09 9.800237e-08 X 139726353 139726540 188 - 1.499 2.203 2.377
ENSG00000101974 E005 300.0058254 0.0197585649 6.378876e-11 1.161645e-09 X 139726541 139727215 675 - 2.219 2.724 1.685
ENSG00000101974 E006 362.6536169 0.0004639506 1.887925e-32 3.804912e-30 X 139727216 139728591 1376 - 2.361 2.690 1.098
ENSG00000101974 E007 86.9484808 0.0003236529 6.500020e-01 7.611117e-01 X 139728592 139728785 194 - 1.805 1.897 0.308
ENSG00000101974 E008 94.6557445 0.0009249431 3.283110e-01 4.717939e-01 X 139728786 139728962 177 - 1.838 1.953 0.389
ENSG00000101974 E009 32.4620361 0.0017976608 3.434653e-04 1.553948e-03 X 139731651 139731755 105 - 1.325 1.650 1.115
ENSG00000101974 E010 2.6218031 0.0058526985 9.495153e-01 9.723974e-01 X 139732435 139732525 91 - 0.463 0.523 0.293
ENSG00000101974 E011 0.9317929 0.0157019995 3.395942e-01 4.835299e-01 X 139737731 139737796 66 - 0.189 0.407 1.514
ENSG00000101974 E012 83.4062860 0.0003573747 2.524944e-01 3.888556e-01 X 139737916 139738069 154 - 1.781 1.905 0.420
ENSG00000101974 E013 80.9879743 0.0003565190 1.277973e-01 2.311030e-01 X 139740991 139741094 104 - 1.794 1.785 -0.031
ENSG00000101974 E014 72.8572033 0.0009745960 6.477912e-02 1.346833e-01 X 139743559 139743624 66 - 1.754 1.719 -0.119
ENSG00000101974 E015 100.6716134 0.0003152457 8.935883e-01 9.359397e-01 X 139745722 139745857 136 - 1.874 1.938 0.215
ENSG00000101974 E016 97.8533994 0.0002939593 6.292135e-01 7.446300e-01 X 139750025 139750152 128 - 1.866 1.914 0.161
ENSG00000101974 E017 59.1001810 0.0004049948 2.136556e-01 3.428404e-01 X 139757808 139757867 60 - 1.662 1.657 -0.018
ENSG00000101974 E018 72.8267840 0.0003424330 2.994025e-01 4.409064e-01 X 139761961 139762097 137 - 1.748 1.762 0.047
ENSG00000101974 E019 31.2182386 0.0008629975 8.590913e-02 1.688360e-01 X 139762098 139762106 9 - 1.404 1.327 -0.268
ENSG00000101974 E020 61.8696942 0.0003919292 1.884285e-01 3.117525e-01 X 139763316 139763418 103 - 1.680 1.671 -0.028
ENSG00000101974 E021 84.5619259 0.0008612369 2.538023e-01 3.904097e-01 X 139768260 139768434 175 - 1.811 1.822 0.038
ENSG00000101974 E022 96.8229594 0.0003100464 2.748591e-02 6.697868e-02 X 139774690 139774953 264 - 1.878 1.842 -0.121
ENSG00000101974 E023 30.0563012 0.0016060890 1.966290e-01 3.220296e-01 X 139782547 139782556 10 - 1.385 1.342 -0.148
ENSG00000101974 E024 83.3733800 0.0094322196 3.759371e-02 8.657091e-02 X 139782557 139782728 172 - 1.822 1.747 -0.254
ENSG00000101974 E025 76.5676765 0.0035310732 1.693304e-04 8.322721e-04 X 139783164 139783267 104 - 1.799 1.625 -0.588
ENSG00000101974 E026 61.7982570 0.0003708672 1.588026e-05 1.007727e-04 X 139785226 139785299 74 - 1.709 1.496 -0.727
ENSG00000101974 E027 62.9741779 0.0004171663 8.288430e-07 7.005524e-06 X 139787173 139787244 72 - 1.722 1.463 -0.885
ENSG00000101974 E028 86.2608013 0.0003150053 1.840043e-04 8.950153e-04 X 139788192 139788343 152 - 1.842 1.712 -0.437
ENSG00000101974 E029 90.8271500 0.0002919256 3.653356e-06 2.683399e-05 X 139789327 139789488 162 - 1.869 1.692 -0.596
ENSG00000101974 E030 99.5607663 0.0126867032 3.467677e-05 2.029537e-04 X 139796273 139796470 198 - 1.916 1.670 -0.831
ENSG00000101974 E031 77.9032775 0.0091320187 2.692573e-03 9.351367e-03 X 139797176 139797326 151 - 1.801 1.651 -0.505
ENSG00000101974 E032 59.0258820 0.0004117774 2.046765e-05 1.266671e-04 X 139798273 139798354 82 - 1.691 1.474 -0.739
ENSG00000101974 E033 55.4151638 0.0081359112 2.397507e-04 1.132274e-03 X 139798679 139798743 65 - 1.665 1.428 -0.809
ENSG00000101974 E034 57.3944633 0.0021915389 6.859943e-06 4.733893e-05 X 139800060 139800110 51 - 1.684 1.426 -0.883
ENSG00000101974 E035 61.9305128 0.0004161675 1.967836e-09 2.759239e-08 X 139802236 139802301 66 - 1.726 1.372 -1.212
ENSG00000101974 E036 47.8291013 0.0004757074 4.578856e-06 3.288663e-05 X 139802302 139802339 38 - 1.610 1.327 -0.974
ENSG00000101974 E037 81.1489369 0.0015131281 2.876685e-07 2.672778e-06 X 139804471 139804599 129 - 1.829 1.584 -0.829
ENSG00000101974 E038 82.8954124 0.0028384775 5.360012e-05 2.997427e-04 X 139814878 139814985 108 - 1.830 1.650 -0.608
ENSG00000101974 E039 62.1249215 0.0064174378 7.688384e-04 3.146149e-03 X 139816863 139816943 81 - 1.706 1.520 -0.636
ENSG00000101974 E040 40.3264287 0.0006906281 3.368505e-03 1.134676e-02 X 139819338 139819427 90 - 1.520 1.358 -0.560
ENSG00000101974 E041 46.7409072 0.0042646855 1.163263e-04 5.970328e-04 X 139826704 139826823 120 - 1.595 1.343 -0.866
ENSG00000101974 E042 0.1515154 0.0425176539 1.000000e+00   X 139832154 139832288 135 - 0.055 0.000 -8.461
ENSG00000101974 E043 32.2963325 0.0006172329 4.293733e-07 3.848211e-06 X 139932016 139932087 72 - 1.457 1.014 -1.565
ENSG00000101974 E044 37.1496705 0.0012049502 9.937503e-06 6.609430e-05 X 139932088 139932498 411 - 1.506 1.176 -1.147
ENSG00000101974 E045 12.0571735 0.0014154651 4.100339e-03 1.342592e-02 X 139932499 139932568 70 - 1.050 0.689 -1.392
ENSG00000101974 E046 18.3790962 0.0010021856 1.827518e-04 8.897438e-04 X 139932569 139932645 77 - 1.221 0.809 -1.523
ENSG00000101974 E047 24.7182714 0.0167101384 9.669812e-03 2.794942e-02 X 139932646 139933000 355 - 1.329 1.077 -0.894
ENSG00000101974 E048 6.1870404 0.0032000666 9.421452e-01 9.676849e-01 X 139933001 139933075 75 - 0.740 0.809 0.278
ENSG00000101974 E049 0.0000000       X 139945200 139945276 77 -