ENSG00000101945

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376687 ENSG00000101945 HEK293_OSMI2_2hA HEK293_TMG_2hB SUV39H1 protein_coding protein_coding 33.69542 59.16248 20.07405 0.5885911 0.180892 -1.558876 28.931171 46.81736 19.224809 5.191296 0.1092249 -1.283632 0.89398750 0.7910333 0.9577667 0.1667333 0.03181349 0.03181349 FALSE TRUE
ENST00000482260 ENSG00000101945 HEK293_OSMI2_2hA HEK293_TMG_2hB SUV39H1 protein_coding processed_transcript 33.69542 59.16248 20.07405 0.5885911 0.180892 -1.558876 3.551381 10.37591 0.115089 5.600197 0.1150890 -6.375529 0.07042917 0.1755000 0.0057000 -0.1698000 0.03578967 0.03181349 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101945 E001 0.000000       X 48695554 48695871 318 +      
ENSG00000101945 E002 125.828620 0.0083943874 0.0540793320 0.1163906117 X 48696734 48696803 70 + 2.070 2.010 -0.204
ENSG00000101945 E003 244.307442 0.0048173571 0.0024638242 0.0086551596 X 48698902 48699047 146 + 2.370 2.293 -0.255
ENSG00000101945 E004 702.704954 0.0057344047 0.0384011969 0.0881039930 X 48700091 48700753 663 + 2.788 2.766 -0.075
ENSG00000101945 E005 2.390585 0.0060928114 0.7825579694 0.8603918520 X 48705261 48705353 93 + 0.420 0.498 0.400
ENSG00000101945 E006 187.127008 0.0005228908 0.3316470058 0.4752834478 X 48706265 48706302 38 + 2.186 2.198 0.041
ENSG00000101945 E007 295.314110 0.0002704647 0.0779815504 0.1562311184 X 48706303 48706411 109 + 2.395 2.396 0.001
ENSG00000101945 E008 6.134905 0.0507587875 0.1352790100 0.2415066492 X 48706412 48706497 86 + 0.934 0.739 -0.761
ENSG00000101945 E009 322.151938 0.0002592477 0.0022047689 0.0078574601 X 48706498 48706627 130 + 2.454 2.427 -0.089
ENSG00000101945 E010 1935.397189 0.0052390776 0.0001489606 0.0007425179 X 48707437 48709016 1580 + 3.116 3.237 0.402