ENSG00000101911

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380663 ENSG00000101911 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPS2 protein_coding protein_coding 29.2852 14.80329 48.93921 2.836502 1.726736 1.724394 5.616837 0.000000 11.8048274 0.0000000 2.6060892 10.2063828 0.12174167 0.00000000 0.23843333 0.238433333 2.162961e-16 2.162961e-16 FALSE TRUE
ENST00000380668 ENSG00000101911 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPS2 protein_coding protein_coding 29.2852 14.80329 48.93921 2.836502 1.726736 1.724394 19.959048 11.616859 32.0417421 2.7017708 1.8362212 1.4629413 0.69809167 0.77410000 0.65756667 -0.116533333 3.000167e-01 2.162961e-16 FALSE TRUE
ENST00000398491 ENSG00000101911 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPS2 protein_coding protein_coding 29.2852 14.80329 48.93921 2.836502 1.726736 1.724394 2.313465 1.208974 3.8982876 0.1997278 0.5888875 1.6808694 0.08179167 0.08246667 0.07983333 -0.002633333 9.663338e-01 2.162961e-16 FALSE TRUE
MSTRG.33907.3 ENSG00000101911 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPS2 protein_coding   29.2852 14.80329 48.93921 2.836502 1.726736 1.724394 0.875196 1.030488 0.7575357 0.6732674 0.4617314 -0.4389549 0.06438333 0.08410000 0.01490000 -0.069200000 7.701197e-01 2.162961e-16 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101911 E001 1.216828 0.0100311152 2.808885e-01 4.207597e-01 X 12791355 12791380 26 + 0.373 0.189 -1.321
ENSG00000101911 E002 10.890688 0.0187921183 1.531699e-01 2.659870e-01 X 12791381 12791405 25 + 1.082 0.936 -0.538
ENSG00000101911 E003 12.110636 0.0106697612 1.281814e-01 2.316296e-01 X 12791406 12791411 6 + 1.122 0.987 -0.491
ENSG00000101911 E004 88.422407 0.0026155176 2.861630e-03 9.857754e-03 X 12791412 12791487 76 + 1.944 1.845 -0.332
ENSG00000101911 E005 177.804814 0.0030269146 6.447864e-04 2.697341e-03 X 12791488 12791619 132 + 2.243 2.154 -0.297
ENSG00000101911 E006 245.891347 0.0014118679 6.846846e-05 3.727448e-04 X 12799207 12799354 148 + 2.378 2.310 -0.228
ENSG00000101911 E007 136.950784 0.0019306124 2.393330e-03 8.440384e-03 X 12799355 12799390 36 + 2.126 2.063 -0.211
ENSG00000101911 E008 9.430705 0.0174027513 6.954638e-01 7.960602e-01 X 12799391 12799399 9 + 0.989 0.986 -0.011
ENSG00000101911 E009 101.190052 0.0003359305 1.786202e-02 4.684126e-02 X 12809234 12809235 2 + 1.990 1.953 -0.124
ENSG00000101911 E010 164.315772 0.0002587871 7.676106e-03 2.296831e-02 X 12809236 12809332 97 + 2.195 2.168 -0.088
ENSG00000101911 E011 103.195916 0.0003110160 4.221542e-01 5.653202e-01 X 12810022 12810083 62 + 1.977 2.000 0.077
ENSG00000101911 E012 146.480584 0.0002396354 3.329719e-02 7.838428e-02 X 12810084 12810146 63 + 2.140 2.126 -0.046
ENSG00000101911 E013 1.103932 0.0113666343 1.234625e-01 2.248892e-01 X 12810147 12810369 223 + 0.200 0.502 1.899
ENSG00000101911 E014 220.735025 0.0003963095 9.163562e-02 1.776877e-01 X 12819507 12819680 174 + 2.311 2.319 0.028
ENSG00000101911 E015 231.322485 0.0002626271 1.477304e-02 3.998099e-02 X 12820644 12820803 160 + 2.336 2.328 -0.028
ENSG00000101911 E016 1030.037352 0.0030286964 1.691893e-11 3.393226e-10 X 12822704 12824222 1519 + 2.918 3.091 0.575