ENSG00000101882

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000652253 ENSG00000101882 HEK293_OSMI2_2hA HEK293_TMG_2hB NKAP protein_coding protein_coding 31.01193 27.0177 38.71195 1.875915 1.893356 0.5187131 16.20374 15.712568 17.42933 1.6855626 0.6551545 0.1495080 0.5285875 0.5788 0.4508000 -0.12800000 0.002763275 0.002763275 FALSE TRUE
MSTRG.34801.4 ENSG00000101882 HEK293_OSMI2_2hA HEK293_TMG_2hB NKAP protein_coding   31.01193 27.0177 38.71195 1.875915 1.893356 0.5187131 12.51254 9.757044 17.86954 0.1966076 1.1507920 0.8723156 0.3969708 0.3640 0.4609333 0.09693333 0.028694593 0.002763275 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101882 E001 0.000000       X 119920536 119920671 136 -      
ENSG00000101882 E002 46.866374 0.0275777316 6.058835e-01 7.261905e-01 X 119920672 119921260 589 - 1.700 1.666 -0.115
ENSG00000101882 E003 47.929766 0.0006143524 4.689192e-03 1.506680e-02 X 119921261 119921923 663 - 1.756 1.607 -0.508
ENSG00000101882 E004 20.645414 0.0034333006 2.911839e-05 1.737994e-04 X 119921924 119922693 770 - 1.469 1.119 -1.227
ENSG00000101882 E005 73.863962 0.0081389941 1.013777e-14 3.330853e-13 X 119922694 119925050 2357 - 2.047 1.560 -1.646
ENSG00000101882 E006 23.840458 0.0206828345 3.028584e-01 4.447825e-01 X 119925051 119925069 19 - 1.443 1.351 -0.320
ENSG00000101882 E007 352.632200 0.0002861385 6.653317e-09 8.477609e-08 X 119925070 119925394 325 - 2.491 2.599 0.361
ENSG00000101882 E008 188.769605 0.0002049735 2.237153e-05 1.371503e-04 X 119930016 119930037 22 - 2.222 2.327 0.350
ENSG00000101882 E009 286.751905 0.0001825396 1.333140e-04 6.736355e-04 X 119930038 119930124 87 - 2.419 2.495 0.251
ENSG00000101882 E010 216.162004 0.0002140581 2.239655e-02 5.650046e-02 X 119930125 119930165 41 - 2.309 2.360 0.170
ENSG00000101882 E011 280.953453 0.0009074161 5.558736e-04 2.369414e-03 X 119931936 119932011 76 - 2.406 2.486 0.269
ENSG00000101882 E012 321.581271 0.0001726379 2.792331e-01 4.189558e-01 X 119932107 119932216 110 - 2.498 2.515 0.056
ENSG00000101882 E013 8.481274 0.0021110774 8.268979e-01 8.911187e-01 X 119932217 119932752 536 - 0.957 0.977 0.075
ENSG00000101882 E014 259.520451 0.0001852777 4.588696e-03 1.478829e-02 X 119934494 119934557 64 - 2.445 2.378 -0.222
ENSG00000101882 E015 322.540475 0.0001701229 1.180831e-04 6.050495e-04 X 119936297 119936428 132 - 2.545 2.465 -0.267
ENSG00000101882 E016 128.420144 0.0007340415 1.058690e-02 3.017967e-02 X 119936429 119936431 3 - 2.154 2.064 -0.299
ENSG00000101882 E017 220.436819 0.0033280354 6.657400e-02 1.376792e-01 X 119936612 119936682 71 - 2.378 2.306 -0.239
ENSG00000101882 E018 1.478854 0.2515263186 1.459391e-01 2.561468e-01 X 119936683 119938077 1395 - 0.197 0.547 2.131
ENSG00000101882 E019 222.531659 0.0002480918 2.098532e-01 3.383783e-01 X 119938730 119938810 81 - 2.364 2.330 -0.115
ENSG00000101882 E020 409.113928 0.0002312129 6.347662e-01 7.491703e-01 X 119943220 119943884 665 - 2.616 2.604 -0.042