ENSG00000101868

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379059 ENSG00000101868 HEK293_OSMI2_2hA HEK293_TMG_2hB POLA1 protein_coding protein_coding 17.6601 10.48628 23.84588 0.7759621 0.6394875 1.184467 1.126494 0.1572430 1.28445231 0.15724298 0.67879590 2.952324 0.06815417 0.01313333 0.05443333 0.0413000 3.393630e-01 5.343404e-25 FALSE TRUE
ENST00000379068 ENSG00000101868 HEK293_OSMI2_2hA HEK293_TMG_2hB POLA1 protein_coding protein_coding 17.6601 10.48628 23.84588 0.7759621 0.6394875 1.184467 11.905950 4.6112387 17.22319327 0.84704879 1.08028423 1.898839 0.60174583 0.45066667 0.72193333 0.2712667 8.960465e-02 5.343404e-25 FALSE TRUE
ENST00000679301 ENSG00000101868 HEK293_OSMI2_2hA HEK293_TMG_2hB POLA1 protein_coding processed_transcript 17.6601 10.48628 23.84588 0.7759621 0.6394875 1.184467 2.045919 4.8570811 0.02547131 1.21786358 0.02547131 -7.100261 0.19441250 0.45416667 0.00110000 -0.4530667 2.017138e-14 5.343404e-25 FALSE TRUE
MSTRG.34044.1 ENSG00000101868 HEK293_OSMI2_2hA HEK293_TMG_2hB POLA1 protein_coding   17.6601 10.48628 23.84588 0.7759621 0.6394875 1.184467 1.632585 0.1082491 4.24145932 0.03766161 0.20755159 5.168057 0.07131667 0.01016667 0.17770000 0.1675333 5.343404e-25 5.343404e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101868 E001 0.4386386 0.1419191425 7.592658e-01 8.436549e-01 X 24693849 24693872 24 + 0.133 0.200 0.700
ENSG00000101868 E002 3.6807596 0.0089960996 3.028423e-01 4.447693e-01 X 24693873 24693908 36 + 0.663 0.526 -0.612
ENSG00000101868 E003 5.3304774 0.0033748089 3.795929e-02 8.727168e-02 X 24693909 24693917 9 + 0.818 0.526 -1.245
ENSG00000101868 E004 18.7771801 0.0009893209 6.238044e-04 2.620004e-03 X 24693918 24693940 23 + 1.307 1.018 -1.032
ENSG00000101868 E005 21.3789109 0.0011851588 2.352777e-04 1.113815e-03 X 24693941 24693946 6 + 1.361 1.064 -1.051
ENSG00000101868 E006 44.4835120 0.0005630062 5.184600e-08 5.572805e-07 X 24693947 24693986 40 + 1.673 1.357 -1.081
ENSG00000101868 E007 44.0795694 0.0007120912 9.722306e-08 9.894528e-07 X 24693987 24694004 18 + 1.668 1.357 -1.064
ENSG00000101868 E008 78.4936919 0.0005950723 4.672721e-11 8.718929e-10 X 24699425 24699549 125 + 1.910 1.625 -0.962
ENSG00000101868 E009 86.4141969 0.0013765046 5.292461e-07 4.658192e-06 X 24703251 24703347 97 + 1.936 1.741 -0.656
ENSG00000101868 E010 88.0012626 0.0002969349 6.962497e-05 3.781931e-04 X 24704389 24704469 81 + 1.930 1.806 -0.417
ENSG00000101868 E011 0.8846520 0.0135565452 6.033631e-01 7.241727e-01 X 24714317 24714553 237 + 0.279 0.201 -0.614
ENSG00000101868 E012 97.3945715 0.0002680449 3.560054e-06 2.621023e-05 X 24714554 24714669 116 + 1.977 1.833 -0.486
ENSG00000101868 E013 62.4155713 0.0003773844 9.247961e-05 4.866933e-04 X 24715141 24715203 63 + 1.787 1.631 -0.529
ENSG00000101868 E014 0.1515154 0.0431128625 1.000000e+00   X 24715204 24716361 1158 + 0.072 0.000 -7.780
ENSG00000101868 E015 98.0473118 0.0004911422 3.215149e-07 2.956224e-06 X 24716362 24716454 93 + 1.984 1.814 -0.573
ENSG00000101868 E016 95.7688498 0.0003731004 1.316770e-07 1.307570e-06 X 24716884 24716971 88 + 1.977 1.798 -0.602
ENSG00000101868 E017 148.8119003 0.0002428249 2.232934e-16 9.206150e-15 X 24717290 24717491 202 + 2.178 1.933 -0.820
ENSG00000101868 E018 120.3062874 0.0002625434 2.700175e-07 2.522138e-06 X 24717580 24717758 179 + 2.067 1.921 -0.488
ENSG00000101868 E019 93.7397840 0.0003179384 1.094532e-04 5.655107e-04 X 24723155 24723267 113 + 1.954 1.840 -0.382
ENSG00000101868 E020 78.4687769 0.0007668290 1.010205e-02 2.901241e-02 X 24724335 24724451 117 + 1.866 1.798 -0.231
ENSG00000101868 E021 0.0000000       X 24724452 24724848 397 +      
ENSG00000101868 E022 0.4804688 0.0212502950 7.591223e-01 8.435350e-01 X 24725211 24725980 770 + 0.134 0.201 0.709
ENSG00000101868 E023 67.8805449 0.0003769346 5.590117e-02 1.195187e-01 X 24725981 24726055 75 + 1.796 1.755 -0.139
ENSG00000101868 E024 0.0000000       X 24726056 24726932 877 +      
ENSG00000101868 E025 88.9765864 0.0016292643 5.453950e-04 2.329623e-03 X 24726933 24727071 139 + 1.930 1.818 -0.379
ENSG00000101868 E026 109.7533438 0.0028069186 1.551137e-05 9.866313e-05 X 24727782 24727936 155 + 2.031 1.879 -0.513
ENSG00000101868 E027 11.5002228 0.0258818085 9.688494e-04 3.851937e-03 X 24727937 24728628 692 + 0.884 1.340 1.649
ENSG00000101868 E028 66.6455462 0.0014095209 4.063579e-04 1.799183e-03 X 24732370 24732454 85 + 1.813 1.676 -0.463
ENSG00000101868 E029 55.1265889 0.0236263240 2.002039e-01 3.264909e-01 X 24733755 24733816 62 + 1.715 1.657 -0.196
ENSG00000101868 E030 0.2934659 0.0291963216 4.382397e-01   X 24733817 24734353 537 + 0.072 0.201 1.707
ENSG00000101868 E031 63.1165250 0.0184409467 4.331840e-01 5.756148e-01 X 24735399 24735488 90 + 1.757 1.753 -0.013
ENSG00000101868 E032 0.1451727 0.0428391703 1.000000e+00   X 24737357 24737624 268 + 0.072 0.000 -7.779
ENSG00000101868 E033 84.6381945 0.0010388318 3.030009e-02 7.255957e-02 X 24737625 24737741 117 + 1.894 1.848 -0.156
ENSG00000101868 E034 96.4807153 0.0035467673 1.556848e-02 4.177624e-02 X 24739375 24739550 176 + 1.957 1.889 -0.230
ENSG00000101868 E035 88.6628055 0.0004557413 6.563457e-02 1.361004e-01 X 24741375 24741504 130 + 1.909 1.883 -0.089
ENSG00000101868 E036 108.6886982 0.0011619923 2.480315e-02 6.147070e-02 X 24742002 24742121 120 + 1.999 1.959 -0.134
ENSG00000101868 E037 102.1636088 0.0061829674 2.599543e-01 3.974399e-01 X 24743230 24743329 100 + 1.962 1.954 -0.029
ENSG00000101868 E038 0.7696683 0.0160467914 4.918495e-01 6.291018e-01 X 24743330 24743608 279 + 0.187 0.338 1.123
ENSG00000101868 E039 0.9921708 0.0401979878 4.384352e-02 9.810110e-02 X 24744600 24744893 294 + 0.134 0.525 2.708
ENSG00000101868 E040 77.2649643 0.0019065805 9.265935e-01 9.577789e-01 X 24745418 24745502 85 + 1.826 1.873 0.159
ENSG00000101868 E041 71.1292219 0.0003610720 5.643427e-02 1.204817e-01 X 24745503 24745542 40 + 1.816 1.777 -0.131
ENSG00000101868 E042 135.3644304 0.0002772529 4.141905e-01 5.575961e-01 X 24748311 24748460 150 + 2.074 2.100 0.084
ENSG00000101868 E043 129.7538868 0.0002811279 5.599522e-02 1.196873e-01 X 24748870 24748992 123 + 2.067 2.052 -0.049
ENSG00000101868 E044 0.6976476 0.1293072972 3.223838e-01 4.656782e-01 X 24775197 24775356 160 + 0.133 0.340 1.724
ENSG00000101868 E045 0.0000000       X 24791833 24793045 1213 +      
ENSG00000101868 E046 0.0000000       X 24793821 24795009 1189 +      
ENSG00000101868 E047 0.0000000       X 24809275 24809495 221 +      
ENSG00000101868 E048 77.3159168 0.0003707054 3.829267e-01 5.270855e-01 X 24809898 24809930 33 + 1.838 1.851 0.046
ENSG00000101868 E049 97.0961899 0.0002866739 6.546020e-01 7.647507e-01 X 24810708 24810800 93 + 1.930 1.965 0.118
ENSG00000101868 E050 146.2702303 0.0002208554 6.704620e-01 7.768875e-01 X 24812658 24812829 172 + 2.106 2.146 0.132
ENSG00000101868 E051 86.3498823 0.0002907889 8.873022e-01 9.319889e-01 X 24812830 24812863 34 + 1.877 1.924 0.159
ENSG00000101868 E052 145.2622032 0.0040168670 1.802601e-01 3.015083e-01 X 24814979 24815111 133 + 2.080 2.189 0.365
ENSG00000101868 E053 121.5791602 0.0029923916 2.149366e-01 3.443506e-01 X 24821452 24821583 132 + 2.005 2.110 0.354
ENSG00000101868 E054 128.7776824 0.0007291528 9.923329e-04 3.932127e-03 X 24826427 24826601 175 + 2.011 2.180 0.566
ENSG00000101868 E055 138.1410808 0.0002712581 3.242007e-04 1.477729e-03 X 24841652 24841830 179 + 2.042 2.212 0.569
ENSG00000101868 E056 1.4801151 0.0096152482 2.307404e-01 3.633431e-01 X 24841831 24841983 153 + 0.279 0.526 1.387
ENSG00000101868 E057 130.7480758 0.0003017054 1.336478e-11 2.727771e-10 X 24843546 24843677 132 + 1.978 2.252 0.916
ENSG00000101868 E058 8.1661259 0.0019905487 8.089356e-03 2.400614e-02 X 24845868 24846033 166 + 0.984 0.656 -1.291
ENSG00000101868 E059 111.1469301 0.0013787386 2.123735e-16 8.769294e-15 X 24888006 24888122 117 + 1.870 2.235 1.225
ENSG00000101868 E060 0.0000000       X 24889129 24890126 998 +      
ENSG00000101868 E061 0.0000000       X 24913975 24914546 572 +      
ENSG00000101868 E062 112.9607995 0.0012534114 2.241455e-17 1.043847e-15 X 24930453 24930549 97 + 1.872 2.242 1.240
ENSG00000101868 E063 480.1625121 0.0153188019 4.034222e-11 7.600151e-10 X 24995805 24996986 1182 + 2.467 2.899 1.438