ENSG00000101844

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372232 ENSG00000101844 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG4A protein_coding protein_coding 8.649692 6.129799 11.46016 0.6798604 0.3213355 0.9016217 6.2704030 3.75083631 8.2912791 0.53145015 0.24592105 1.142280 0.70040833 0.6238 0.72343333 0.09963333 0.638054247 0.005052296 FALSE TRUE
ENST00000489247 ENSG00000101844 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG4A protein_coding processed_transcript 8.649692 6.129799 11.46016 0.6798604 0.3213355 0.9016217 0.6283499 1.56732911 0.1825441 0.70330295 0.18254412 -3.034223 0.10746667 0.2462 0.01600000 -0.23020000 0.037043014 0.005052296 FALSE FALSE
MSTRG.34709.1 ENSG00000101844 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG4A protein_coding   8.649692 6.129799 11.46016 0.6798604 0.3213355 0.9016217 0.3439654 0.05608594 1.1068559 0.05608594 0.05045069 4.078956 0.03052917 0.0086 0.09693333 0.08833333 0.005052296 0.005052296 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101844 E001 2.8808017 0.0054250039 0.001863098 0.006799034 X 108088872 108088970 99 + 0.720 0.161 -3.243
ENSG00000101844 E002 1.5373740 0.2215140963 0.722736480 0.816805314 X 108091668 108091768 101 + 0.382 0.442 0.323
ENSG00000101844 E003 1.4621311 0.2108852477 0.256603203 0.393580541 X 108091769 108091777 9 + 0.288 0.510 1.249
ENSG00000101844 E004 1.4621311 0.2108852477 0.256603203 0.393580541 X 108091778 108091783 6 + 0.288 0.510 1.249
ENSG00000101844 E005 7.5088012 0.0345881327 0.970292633 0.985413469 X 108091784 108091809 26 + 0.920 0.914 -0.021
ENSG00000101844 E006 19.2756275 0.0045930443 0.660267353 0.768962975 X 108091810 108091836 27 + 1.283 1.334 0.179
ENSG00000101844 E007 1.9981362 0.0073484534 0.729019057 0.821323494 X 108091837 108091879 43 + 0.495 0.446 -0.245
ENSG00000101844 E008 38.4609069 0.0007275273 0.437312594 0.579284694 X 108126077 108126187 111 + 1.602 1.572 -0.101
ENSG00000101844 E009 6.3944518 0.0044406904 0.259117576 0.396490138 X 108126793 108127094 302 + 0.908 0.773 -0.522
ENSG00000101844 E010 38.3966570 0.0005613505 0.130989864 0.235518447 X 108128781 108128852 72 + 1.617 1.545 -0.245
ENSG00000101844 E011 52.2858893 0.0005190973 0.156597113 0.270566940 X 108131260 108131358 99 + 1.741 1.686 -0.186
ENSG00000101844 E012 50.0541861 0.0128964862 0.074576857 0.150858616 X 108134057 108134158 102 + 1.743 1.636 -0.363
ENSG00000101844 E013 48.5426106 0.0005828111 0.530066520 0.662751946 X 108134339 108134411 73 + 1.698 1.682 -0.055
ENSG00000101844 E014 47.7515652 0.0006377158 0.305671107 0.447792099 X 108137091 108137170 80 + 1.657 1.724 0.228
ENSG00000101844 E015 49.2842349 0.0009183617 0.352888634 0.497134644 X 108137804 108137884 81 + 1.673 1.735 0.211
ENSG00000101844 E016 51.2148865 0.0005011255 0.684792337 0.787692660 X 108137885 108137991 107 + 1.714 1.709 -0.016
ENSG00000101844 E017 48.5920198 0.0004698605 0.042621847 0.095853240 X 108138113 108138191 79 + 1.720 1.630 -0.304
ENSG00000101844 E018 1.9283056 0.0094586874 0.889446781 0.933327147 X 108150032 108150067 36 + 0.461 0.446 -0.074
ENSG00000101844 E019 3.6642195 0.0096977649 0.073246458 0.148713647 X 108150068 108150151 84 + 0.527 0.805 1.189
ENSG00000101844 E020 73.9600961 0.0003812015 0.281678518 0.421597097 X 108150152 108150297 146 + 1.877 1.848 -0.098
ENSG00000101844 E021 46.7240717 0.0005010394 0.638514389 0.752136665 X 108151802 108151858 57 + 1.675 1.665 -0.031
ENSG00000101844 E022 0.3697384 0.0247744591 0.080860010 0.160883531 X 108151859 108152005 147 + 0.000 0.278 10.736
ENSG00000101844 E023 75.9527646 0.0004147776 0.501361353 0.637518991 X 108152979 108153087 109 + 1.880 1.867 -0.043
ENSG00000101844 E024 224.8558026 0.0056167213 0.002422965 0.008531082 X 108153642 108154671 1030 + 2.295 2.410 0.382